Cellular senescence in aging and age-related disease: from mechanisms to therapy

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

SHP2: a new target for pro-senescence cancer therapies

(2015) M. Serrano   EMBO JOURNAL

Cardiovascular disease in Adult Life after Childhood Cancer in Scandinavia: A population-based cohort study of 32,308 one-year survivors

(2015) Thorgerdur Gudmundsdottir et al.   INTERNATIONAL JOURNAL OF CANCER

Atherosclerosis and the role of immune cells

(2015) Fulya Ilhan   World Journal of Clinical Cases

Effect of IL-6 on the insulin sensitivity in patients with type 2 diabetes

(2014) N. M. Harder-Lauridsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes

(2014) Dan Gao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cognitive function and social attainment in adult survivors of retinoblastoma: A report from the St. Jude Lifetime Cohort Study

(2014) Tara M. Brinkman et al.   CANCER

Frailty in childhood cancer survivors

(2014) Kirsten K. Ness et al.   CANCER

Geroconversion of aged muscle stem cells under regenerative pressure

(2014) Pedro Sousa-Victor et al.   CELL CYCLE

HLA-G-mediated NK cell senescence promotes vascular remodeling: implications for reproduction

(2014) Sumati Rajagopalan   Cellular & Molecular Immunology

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

Proteomic Analysis Reveals a Role for Bcl2-associated Athanogene 3 and Major Vault Protein in Resistance to Apoptosis in Senescent Cells by Regulating ERK1/2 Activation

(2014) Martina P. Pasillas et al.   MOLECULAR & CELLULAR PROTEOMICS

Necessary and Sufficient Role for a Mitosis Skip in Senescence Induction

(2014) Yoshikazu Johmura et al.   MOLECULAR CELL

Geriatric muscle stem cells switch reversible quiescence into senescence

(2014) Pedro Sousa-Victor et al.   NATURE

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice

(2014) Jennifer D Bernet et al.   NATURE MEDICINE

Activation of a promyelocytic leukemia–tumor protein 53 axis underlies acute promyelocytic leukemia cure

(2014) Julien Ablain et al.   NATURE MEDICINE

Spartan deficiency causes genomic instability and progeroid phenotypes

(2014) Reeja S. Maskey et al.   Nature Communications

Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

(2014) Alberto Toso et al.   Cell Reports

Reductions in serum IGF-1 during aging impair health span

(2013) Zhenwei Gong et al.   AGING CELL

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

(2013) Christin E. Burd et al.   CELL

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress-dependent p21 signaling

(2013) Jun Liu et al.   CELLULAR SIGNALLING

 -Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?

(2013) S. Costes et al.   DIABETES

Davallialactone from Mushroom Reduced Premature Senescence and Inflammation on Glucose Oxidative Stress in Human Diploid Fibroblast Cells

(2013) Tae-Ki Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Probing the depths of cellular senescence

(2013) Darren J. Baker et al.   JOURNAL OF CELL BIOLOGY

Physiologic Frailty As a Sign of Accelerated Aging Among Adult Survivors of Childhood Cancer: A Report From the St Jude Lifetime Cohort Study

(2013) Kirsten K. Ness et al.   JOURNAL OF CLINICAL ONCOLOGY

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

(2013) Jan R. Dörr et al.   NATURE

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

High Glucose Induced Alteration of SIRTs in Endothelial Cells Causes Rapid Aging in a p300 and FOXO Regulated Pathway

(2013) Rokhsana Mortuza et al.   PLoS One

Pre-Transplant CDKN2A Expression in Kidney Biopsies Predicts Renal Function and Is a Future Component of Donor Scoring Criteria

(2013) Marc Gingell-Littlejohn et al.   PLoS One

Expression of the senescence marker p16INK4a in skin biopsies of acute lymphoblastic leukemia survivors: a pilot study

(2013) Sophie Marcoux et al.   Radiation Oncology

Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and Humans

(2013) S. Titus et al.   Science Translational Medicine

Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema

(2013) Marco Chilosi et al.   Translational Research

p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice

(2013) Darren J. Baker et al.   Cell Reports

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Is cellular senescence an example of antagonistic pleiotropy?

(2012) Stefano Giaimo et al.   AGING CELL

Increased dosage ofInk4/Arfprotects against glucose intolerance and insulin resistance associated with aging

(2012) Herminia González-Navarro et al.   AGING CELL

The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype

(2012) Geunwon Kim et al.   AGING CELL

IGF-IR signaling attenuates the age-related decline of diastolic cardiac function

(2012) Sarah Moellendorf et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies

(2012) L. Hoenicke et al.   CARCINOGENESIS

p53-Induced Adipose Tissue Inflammation Is Critically Involved in the Development of Insulin Resistance in Heart Failure

(2012) Ippei Shimizu et al.   Cell Metabolism

Aging and Atherosclerosis

(2012) Julie C. Wang et al.   CIRCULATION RESEARCH

Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

(2012) Xiaoni Kong et al.   HEPATOLOGY

Gamma radiation induces senescence in human adult mesenchymal stem cells from bone marrow and periodontal ligaments

(2012) Jana Cmielova et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes

(2012) Haibin Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cellular Senescence Limits Regenerative Capacity and Allograft Survival

(2012) H. Braun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Senescence-escape in melanoma

(2012) Wenjin Liu et al.   Pigment Cell & Melanoma Research

Dexamethasone Reduces Sensitivity to Cisplatin by Blunting p53-Dependent Cellular Senescence in Non-Small Cell Lung Cancer

(2012) Haiyan Ge et al.   PLoS One

A New Definition of Aging?

(2012) Thomas Flatt   Frontiers in Genetics

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

Forecasting the Future of Cardiovascular Disease in the United States

(2011) Paul A. Heidenreich et al.   CIRCULATION

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer

(2011) C. Thangavel et al.   ENDOCRINE-RELATED CANCER

MicroRNA changes in human arterial endothelial cells with senescence: Relation to apoptosis, eNOS and inflammation

(2011) Catarina Rippe et al.   EXPERIMENTAL GERONTOLOGY

Senescent cells develop a PARP-1 and nuclear factor- B-associated secretome (PNAS)

(2011) M. Ohanna et al.   GENES & DEVELOPMENT

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

(2011) Kan Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Short Telomeres Compromise β-Cell Signaling and Survival

(2011) Nini Guo et al.   PLoS One

TGF-  signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells

(2011) R. Cipriano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-486-5p Induces Replicative Senescence of Human Adipose Tissue-Derived Mesenchymal Stem Cells and Its Expression Is Controlled by High Glucose

(2011) Yeon Jeong Kim et al.   STEM CELLS AND DEVELOPMENT

Identification of CD44 as a senescence-induced cell adhesion gene responsible for the enhanced monocyte recruitment to senescent endothelial cells

(2010) Gyeong In Mun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Concept of Vulnerable/Unstable Plaque

(2010) Aloke V. Finn et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Senescence-associated beta-galactosidase activity expression in aging hippocampal neurons

(2010) Yi-Qun Geng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-ageing and rejuvenating effects of quercetin

(2010) Niki Chondrogianni et al.   EXPERIMENTAL GERONTOLOGY

Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence

(2010) E. K. Benson et al.   JOURNAL OF CELL SCIENCE

Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity

(2010) Jun Lu et al.   JOURNAL OF PATHOLOGY

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen

(2010) Jean-Philippe Coppé et al.   PLoS One

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Telomere length in atherosclerosis and diabetes

(2009) Klelia D. Salpea et al.   ATHEROSCLEROSIS

Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice

(2009) Nathalie Dhomen et al.   CANCER CELL

Interleukin-6 maintains bone marrow-derived mesenchymal stem cell stemness by an ERK1/2-dependent mechanism

(2009) Katie L. Pricola et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The PPAR  Agonist Pioglitazone Ameliorates Aging-Related Progressive Renal Injury

(2009) H.-C. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Higher Inflammatory Marker Levels in Older Persons: Associations With 5-Year Change in Muscle Mass and Muscle Strength

(2009) L. A. Schaap et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

(2009) R.F. Loeser   OSTEOARTHRITIS AND CARTILAGE

Differential p53-Independent Outcomes of p19Arf Loss in Oncogenesis

(2009) Z. Chen et al.   Science Signaling

Markers of cellular senescence in zero hour biopsies predict outcome in renal transplantation

(2008) Christian Koppelstaetter et al.   AGING CELL

Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage

(2008) Yasuhiro Maejima et al.   AGING CELL

Effects of Donor Age and Cell Senescence on Kidney Allograft Survival

(2008) A. Melk et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Regulation of IGF-I function by proinflammatory cytokines: At the interface of immunology and endocrinology

(2008) Jason C. O’Connor et al.   CELLULAR IMMUNOLOGY

Ataxia Telangiectasia Mutated and p21CIP1 Modulate Cell Survival of Drug-Induced Senescent Tumor Cells: Implications for Chemotherapy

(2008) E. Crescenzi et al.   CLINICAL CANCER RESEARCH

Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle

(2008) I. Nieto-Vazquez et al.   DIABETES

Health effects of quercetin: From antioxidant to nutraceutical

(2008) Agnes W. Boots et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Quercetin-mediated longevity in Caenorhabditis elegans: Is DAF-16 involved?

(2008) Nadine Saul et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Antagonistic pleiotropy and p53

(2008) Erica Ungewitter et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

(2008) Darren J. Baker et al.   NATURE CELL BIOLOGY

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin

(2007) Andreas Kampkötter et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY