Vaccines againstToxoplasma gondii: new developments and perspectives

Induction of long-lasting protective immunity against Toxoplasma gondii in BALB/c mice by recombinant surface antigen 1 protein encapsulated in poly (lactide-co-glycolide) microparticles

(2013) Shu-Chun Chuang et al.   Parasites & Vectors

Protective Efficacy of a Toxoplasma gondii Rhoptry Protein 13 Plasmid DNA Vaccine in Mice

(2012) Pei-Yuan Wang et al.   Clinical and Vaccine Immunology

Epidemiology of and Diagnostic Strategies for Toxoplasmosis

(2012) F. Robert-Gangneux et al.   CLINICAL MICROBIOLOGY REVIEWS

Toxoplasma gondii: The vaccine potential of three trivalent antigen-cocktails composed of recombinant ROP2, ROP4, GRA4 and SAG1 proteins against chronic toxoplasmosis in BALB/c mice

(2012) Bozena Dziadek et al.   EXPERIMENTAL PARASITOLOGY

Initial characterization of an autoclaved Toxoplasma vaccine in mice

(2012) Maha M. Eissa et al.   EXPERIMENTAL PARASITOLOGY

Oocyst shedding in cats vaccinated by the nasal and rectal routes with crude rhoptry proteins of Toxoplasma gondii

(2012) Dauton Luiz Zulpo et al.   EXPERIMENTAL PARASITOLOGY

Toxoplasma gondii: Protective immunity against toxoplasmosis with recombinant actin depolymerizing factor protein in BALB/c mice

(2012) Xiangsheng Huang et al.   EXPERIMENTAL PARASITOLOGY

The Toxoplasma gondii Peptide AS15 Elicits CD4 T Cells That Can Control Parasite Burden

(2012) Harshita Satija Grover et al.   INFECTION AND IMMUNITY

Transcriptomics: mRNA and alternative splicing

(2012) Alex Sánchez-Pla et al.   JOURNAL OF NEUROIMMUNOLOGY

Epidemiology of Ocular Toxoplasmosis

(2012) Eskild Petersen et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

The protective effect of a DNA vaccine encoding the Toxoplasma gondii cyclophilin gene in BALB/c mice

(2012) P. Gong et al.   PARASITE IMMUNOLOGY

Evaluation of protective immune responses induced by DNA vaccines encoding Toxoplasma gondii surface antigen 1 (SAG1) and 14-3-3 protein in BALB/c mice

(2012) Min Meng et al.   Parasites & Vectors

Toxoplasmosis in humans and animals in Brazil: high prevalence, high burden of disease, and epidemiology

(2012) J. P. DUBEY et al.   PARASITOLOGY

Protective effect of a prime-boost strategy with plasmid DNA followed by recombinant adenovirus expressing TgAMA1 as vaccines against Toxoplasma gondii infection in mice

(2012) Longzheng Yu et al.   PARASITOLOGY INTERNATIONAL

Multicomponent DNA vaccine-encoding Toxoplasma gondii GRA1 and SAG1 primes: anti-Toxoplasma immune response in mice

(2012) Xiao-Nan Wu et al.   PARASITOLOGY RESEARCH

A chloroplast-derivedToxoplasma gondiiGRA4 antigen used as an oral vaccine protects against toxoplasmosis in mice

(2012) María del L. Yácono et al.   PLANT BIOTECHNOLOGY JOURNAL

Application and expression of Toxoplasma gondii surface antigen 2 (SAG2) and rhoptry protein 2 (ROP2) from recombinant Escherichia coli strain

(2012) Hua Yan et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Protective immune response against Toxoplasma gondii elicited by a recombinant DNA vaccine with a novel genetic adjuvant

(2012) Huaiyu Zhou et al.   VACCINE

Enhancement of protective immune responses induced by Toxoplasma gondii dense granule antigen 7 (GRA7) against toxoplasmosis in mice using a prime-boost vaccination strategy

(2012) Juan Min et al.   VACCINE

Toxoplasma gondii immune mapped protein-1 (TgIMP1) is a novel vaccine candidate against toxoplasmosis

(2012) Xia Cui et al.   VACCINE

A Toxoplasma gondii Pseudokinase Inhibits Host IRG Resistance Proteins

(2012) Martin C. Fleckenstein et al.   PLOS BIOLOGY

The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response

(2012) Wendy Niedelman et al.   PLoS Pathogens

The Polymorphic Pseudokinase ROP5 Controls Virulence in Toxoplasma gondii by Regulating the Active Kinase ROP18

(2012) Michael S. Behnke et al.   PLoS Pathogens

Combination of CpG-oligodeoxynucleotides with recombinant ROP2 or GRA4 proteins induces protective immunity against Toxoplasma gondii infection

(2011) Vanesa R. Sánchez et al.   EXPERIMENTAL PARASITOLOGY

Toxoplasma gondii: Protective immunity against experimental toxoplasmosis induced by a DNA vaccine encoding the perforin-like protein 1

(2011) Hai-Kuo Yan et al.   EXPERIMENTAL PARASITOLOGY

Toxoplasma gondii: Identification and immune response against a group of proteins involved in cellular invasion

(2011) Samira Azzouz et al.   EXPERIMENTAL PARASITOLOGY

The long-term potential of biodegradable poly(lactideco-glycolide) microparticles as the next-generation vaccine adjuvant

(2011) Siddhartha Jain et al.   Expert Review of Vaccines

Toxoplasma in Animals, Food, and Humans: An Old Parasite of New Concern

(2011) Beniamino T. Cenci-Goga et al.   Foodborne Pathogens and Disease

Toxoplasma gondii HLA-B*0702-restricted GRA720-28 peptide with adjuvants and a universal helper T cell epitope elicits CD8+ T cells producing interferon-γ and reduces parasite burden in HLA-B*0702 mice

(2011) Hua Cong et al.   HUMAN IMMUNOLOGY

Humoral responses and immune protection in mice immunized with irradiated T. gondii tachyzoites and challenged with three genetically distinct strains of T. gondii

(2011) Nahiara Esteves Zorgi et al.   IMMUNOLOGY LETTERS

Toxoplasma gondii infection in humans in China

(2011) Peng Zhou et al.   Parasites & Vectors

DNA vaccination with a gene encoding Toxoplasma gondii GRA6 induces partial protection against toxoplasmosis in BALB/c mice

(2011) Xi-Meng Sun et al.   Parasites & Vectors

Toxoplasma gondii infection in pregnant women in China

(2011) X.-J. GAO et al.   PARASITOLOGY

Comparative evaluation of immunization with recombinant protein and plasmid DNA vaccines of fusion antigen ROP2 and SAG1 from Toxoplasma gondii in mice: cellular and humoral immune responses

(2011) Wen-Shu Li et al.   PARASITOLOGY RESEARCH

Immunogenic characterization of the chimeric surface antigen 1 and 2 (SAG1/2) of Toxoplasma gondii expressed in the yeast Pichia pastoris

(2011) Yee Ling Lau et al.   PARASITOLOGY RESEARCH

Induction of protective Th1 immune responses in mice by vaccination with recombinant Toxoplasma gondii nucleoside triphosphate hydrolase-II

(2011) Feng Tan et al.   VACCINE

Increased survival time in mice vaccinated with a branched lysine multiple antigenic peptide containing B- and T-cell epitopes from T. gondii antigens

(2011) Yanhua Wang et al.   VACCINE

Innate immunity in DNA vaccine with Toxoplasma gondii-heat shock protein 70 gene that induces DC activation and Th1 polarization

(2011) Masayuki Makino et al.   VACCINE

MyD88-dependent protective immunity elicited by adenovirus 5 expressing the surface antigen 1 from Toxoplasma gondii is mediated by CD8+ T lymphocytes

(2011) Érica A. Mendes et al.   VACCINE

Protective effect against toxoplasmosis in mice induced by DNA immunization with gene encoding Toxoplasma gondii ROP18

(2011) Zi-Guo Yuan et al.   VACCINE

Modulation of immune response to Toxoplasma gondii in sheep by immunization with a DNA vaccine encoding ROP1 antigen as a fusion protein with ovine CD154

(2011) Elżbieta Hiszczyńska-Sawicka et al.   VETERINARY PARASITOLOGY

Immune response and protective efficacy against homologous challenge in BALB/c mice vaccinated with DNA vaccine encoding Toxoplasma gondii actin depolymerizing factor gene

(2011) Jianhua Li et al.   VETERINARY PARASITOLOGY

Immunogenicity and protective efficacy of two recombinant pseudorabies viruses expressing Toxoplasma gondii SAG1 and MIC3 proteins

(2011) Hao Nie et al.   VETERINARY PARASITOLOGY

Humoral and cellular immune responses in pigs immunized intranasally with crude rhoptry proteins of Toxoplasma gondii plus Quil-A

(2011) Ivo Alexandre Leme da Cunha et al.   VETERINARY PARASITOLOGY

Evaluation of immune responses induced by SAG1 and MIC3 vaccine cocktails against Toxoplasma gondii

(2011) Rui Fang et al.   VETERINARY PARASITOLOGY

Toxoplasma gondii rhomboid protein 1 (TgROM1) is a potential vaccine candidate against toxoplasmosis

(2011) Jianhua Li et al.   VETERINARY PARASITOLOGY

Effect of codon optimization and subcellular targeting on Toxoplasma gondii antigen SAG1 expression in tobacco leaves to use in subcutaneous and oral immunization in mice

(2010) Melina Laguía-Becher et al.   BMC BIOTECHNOLOGY

Protective Immunity Induced byToxoplasma gondiiRhoptry Protein 16 against Toxoplasmosis in Mice

(2010) Zi-Guo Yuan et al.   Clinical and Vaccine Immunology

Vaccination againstToxoplasma gondii: an increasing priority for collaborative research?

(2010) Elisabeth A Innes   Expert Review of Vaccines

Vaccines against Toxoplasma gondii: challenges and opportunities

(2010) Erik Jongert et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Protective immunity against lethal anaphylactic reaction in Toxoplasma gondii-infected mice by DNA vaccination with T. gondii-derived heat shock protein 70 gene

(2010) Akitoshi Kikumura et al.   PARASITOLOGY INTERNATIONAL

Toxoplasma gondii microneme protein 8 (MIC8) is a potential vaccine candidate against toxoplasmosis

(2010) M. M. Liu et al.   PARASITOLOGY RESEARCH

The protective effect of a Toxoplasma gondii SAG1 plasmid DNA vaccine in mice is enhanced with IL-18

(2010) Quan Liu et al.   RESEARCH IN VETERINARY SCIENCE

Immunogenetics of Toxoplasma gondii informs vaccine design

(2010) Fiona L. Henriquez et al.   TRENDS IN PARASITOLOGY

Functional characterization of in vivo effector CD4+ and CD8+ T cell responses in acute Toxoplasmosis: An interplay of IFN-γ and cytolytic T cells

(2010) Erik Jongert et al.   VACCINE

Prime and boost immunization with influenza and adenovirus encoding the Toxoplasma gondii surface antigen 2 (SAG2) induces strong protective immunity

(2010) Alexandre V. Machado et al.   VACCINE

Construction of Neospora caninum stably expressing TgSAG1 and evaluation of its protective effects against Toxoplasma gondii infection in mice

(2010) Guohong Zhang et al.   VACCINE

Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans

(2010) Tze Guan Tan et al.   VACCINE

Evaluation of three recombinant multi-antigenic vaccines composed of surface and secretory antigens of Toxoplasma gondii in murine models of experimental toxoplasmosis

(2010) Bozena Dziadek et al.   VACCINE

Towards an immunosense vaccine to prevent toxoplasmosis: Protective Toxoplasma gondii epitopes restricted by HLA-A*0201

(2010) Hua Cong et al.   VACCINE

Evaluation of the immune response induced by DNA vaccine cocktail expressing complete SAG1 and ROP2 genes against toxoplasmosis

(2010) K. Hoseinian Khosroshahi et al.   VACCINE

The immune responses of sheep after DNA immunization with, Toxoplasma gondii MAG1 antigen—with and without co-expression of ovine interleukin 6

(2010) Elżbieta Hiszczyńska-Sawicka et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Evaluation of immune responses in sheep induced by DNA immunization with genes encoding GRA1, GRA4, GRA6 and GRA7 antigens of Toxoplasma gondii

(2010) Elżbieta Hiszczyńska-Sawicka et al.   VETERINARY PARASITOLOGY

Mic1-3 KnockoutToxoplasma gondiiis a good candidate for a vaccine againstT. gondii-induced abortion in sheep

(2010) Marie-Noëlle Mévélec et al.   VETERINARY RESEARCH

Toxoplasma gondii: Protective effect of an intranasal SAG1 and MIC4 DNA vaccine in mice

(2009) Huaxin Wang et al.   EXPERIMENTAL PARASITOLOGY

Comparison of immune response in sheep immunized with DNA vaccine encoding Toxoplasma gondii GRA7 antigen in different adjuvant formulations

(2009) Elżbieta Hiszczyńska-Sawicka et al.   EXPERIMENTAL PARASITOLOGY

Vaccination concepts againstToxoplasma gondii

(2009) João Luis Garcia   Expert Review of Vaccines

Current status of toxoplasmosis vaccine development

(2009) Józef Kur et al.   Expert Review of Vaccines

Long-Term Immunity to Lethal Acute or Chronic Type II Toxoplasma gondii Infection Is Effectively Induced in Genetically Susceptible C57BL/6 Mice by Immunization with an Attenuated Type I Vaccine Strain

(2009) J. P. Gigley et al.   INFECTION AND IMMUNITY

Protective immunity against Toxoplasma challenge in mice by coadministration of T. gondii antigens and Eimeria profilin-like protein as an adjuvant

(2009) Dorsaf Hedhli et al.   VACCINE

Further analysis of protection induced by the MIC3 DNA vaccine against T. gondii: CD4 and CD8 T cells are the major effectors of the MIC3 DNA vaccine-induced protection, both Lectin-like and EGF-like domains of MIC3 conferred protection

(2009) Alaa Bassuny Ismael et al.   VACCINE

Protection in mice immunized with a heterologous prime-boost regime using DNA and recombinant pseudorabies expressing TgSAG1 against Toxoplasma gondii challenge

(2009) Limin Shang et al.   VACCINE

Induction of partial protection against infection with Toxoplasma gondii genotype II by DNA vaccination with recombinant chimeric tachyzoite antigens

(2009) Carina Rosenberg et al.   VACCINE

Toxoplasma gondii microneme protein 6 (MIC6) is a potential vaccine candidate against toxoplasmosis in mice

(2009) Gao-Hui Peng et al.   VACCINE

Evaluation of the adjuvant properties of Astragalus membranaceus and Scutellaria baicalensis GEORGI in the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models

(2009) Xiaoyan Yang et al.   VACCINE

Toxoplasma gondii: Prototype immunization of lambs against formation of muscle and brain cysts

(2009) J. Falcón et al.   VETERINARY PARASITOLOGY

Protective immune response in BALB/c mice induced by a suicidal DNA vaccine of the MIC3 gene of Toxoplasma gondii

(2009) Rui Fang et al.   VETERINARY PARASITOLOGY

Emerging food-borne parasites

(2009) P. Dorny et al.   VETERINARY PARASITOLOGY

Control of the risk of human toxoplasmosis transmitted by meat

(2008) Aize Kijlstra et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Toxoplasma gondii infection in humans and animals in the United States

(2008) J DUBEY et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum

(2008) Nicolas Blanchard et al.   NATURE IMMUNOLOGY

Protective effect of a multiantigenic DNA vaccine against Toxoplasma gondii with co-delivery of IL-12 in mice

(2008) Y.-L. CUI et al.   PARASITE IMMUNOLOGY

Toxoplasma gondii infection in pregnant women in China

(2008) Quan Liu et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

An enhanced GRA1–GRA7 cocktail DNA vaccine primes anti-Toxoplasma immune responses in pigs

(2007) E. Jongert et al.   VACCINE