Article
Cell Biology
Ho-won Seo, Tae-Young Ha, Geon Ko, Aram Jang, Ji-Woong Choi, Dong-hun Lee, Keun-A Chang
Summary: Stroke is a global health problem causing significant mortality and disability, with underestimated post-stroke neurological impairment. The scientific efficacy of traditional Chinese medicines for stroke remains unclear. This study investigated the therapeutic effects of Scutellaria baicalensis extraction (SB) in ischemic stroke, demonstrating its neuroprotective and functional recovery properties through modulation of programmed cell death pathways.
Article
Multidisciplinary Sciences
Yaojun Wang, Ming Ding, Jiaoni Chi, Tao Wang, Yue Zhang, Zhimin Li, Qiang Li
Summary: This study aims to discover the therapeutic mechanisms and potential drug targets of Astragalus membranaceus (AM) on vitiligo combined with COVID-19. By using databases such as TCMSP, GEO, and Genecards, target genes of AM, vitiligo disease, and COVID-19 were established. The crossover genes were identified and analyzed using GO, KEGG enrichment analysis, and PPI network.
SCIENTIFIC REPORTS
(2023)
Article
Agronomy
Na Miao, Cholil Yun, Shulan Han, Yutong Shi, Yuan Gao, Shuang Wu, Zhuowen Zhao, Huimei Wang, Wenjie Wang
Summary: This study investigated the effects of postharvest UV-A radiation on the flavonoid content, composition, and bioactivity in Scuteilaria baicalensis roots. The results showed that postharvest UV-A radiation increased the total flavonoid content in the roots and led to changes in flavonoid composition. Furthermore, UV-A radiation enhanced the antioxidant and antibacterial activities of the root extracts.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Nova Syafni, Seema Devi, Amy M. Zimmermann-Klemd, Jakob K. Reinhardt, Ombeline Danton, Carsten Gruendemann, Matthias Hamburger
Summary: This study identified immunosuppressant compounds in the roots of Scutellaria baicalensis, including flavonoids that inhibited T-cell proliferation at non-cytotoxic concentrations. These findings support the potential use of S. baicalensis in disorders where modulation of the cellular immune response is desirable.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Agricultural Engineering
Na Miao, Cholil Yun, Yutong Shi, Yuan Gao, Shuang Wu, Zhonghua Zhang, Shulan Han, Huimei Wang, Wenjie Wang
Summary: This study demonstrates that UV-A radiation can effectively increase the flavonoid content in the aerial parts of Scutellaria baicalensis and enhance its antioxidant activity.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Juyoung Hwang, Wei Zhang, Yadav Dhananjay, Eun-Koung An, Minseok Kwak, Sang Guan You, Peter Chang-Whan Lee, Jun-O Jin
Summary: Intranasal administration of Astragalus membranaceus polysaccharides (APS) activated mucosal immune cell populations and inhibited pulmonary metastatic melanoma in mice by stimulating NK cells and T cells in the mesenteric lymph nodes. The combination treatment of APS with anti-PD-L1 antibody showed a synergistic effect in inhibiting melanoma cell infiltration, with NK cells and CD8 T cells playing a critical role in mediating the anti-cancer immunity. These findings suggest that APS could serve as a topical mucosal adjuvant to enhance the anti-cancer effect of immune checkpoint inhibitors.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Qianbo Song, Sau Wan Cheng, Dan Li, Huiyuan Cheng, Yuen Sze Lai, Quanbin Han, Hoi Yan Wu, Pang Chui Shaw, Zhong Zuo
Summary: This study investigated the role of gut microbiota in the hypoglycemic effect of Astragalus membranaceus polysaccharides (AMP) in db/db mice. Treatment with AMP significantly alleviated diabetic symptoms and restored gut microbiota community, leading to increased production of short chain fatty acids (SCFA) in feces. The relative abundance of two intestinal bacteria, Akkermansia and Faecalibaculum, were found to be positively correlated with the hypoglycemic effect of AMP and fecal SCFA production. Furthermore, AMP treatment stimulated the secretion of glucagon-like peptide-1 (GLP-1) and improved intestinal integrity. Mechanistic study revealed that the increased SCFA after AMP treatment could enhance the expression of G protein-coupled receptors 41/43 and tight junction proteins, resulting in the alleviation of diabetic symptoms in db/db mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Yanan Xu, Weifeng Wu, Yi Chen, Tingting Zhang, Keling Tu, Yun Hao, Hailu Cao, Xuehui Dong, Qun Sun
Summary: The non-destructive and highly accurate discrimination of Astragalus membranaceus var. mongholicus, A. membranaceus, and similar seeds using hyperspectral imaging was achieved, providing support for standardization in the Astragalus production industry.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Medicinal
S. M. Gulyaev, T. A. Turtueva, G. G. Nikolaeva
Summary: The study aimed to determine the phenolic compound content in the extract from three different roots and assess its antioxidant activity and anti-inflammatory effect. The quantification of flavonoid complex, including baicalin, rutin, quercetin, and epicatechin, was conducted. The extract showed concentration-dependent antioxidant activity, with IC50 value of 210.99 μg/mL. The anti-inflammatory effect of the extract was comparable to that of indomethacin, significantly reducing edema in rats.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Guanghui Sun, Yongkang Dang, Yanke Lin, Wanying Zeng, Zongjian Wu, Xingwang Zhang, Dong Dong, Baojian Wu
Summary: The study reveals that Scutellaria baicalensis Georgi (SBG) can counteract skin aging by antagonizing REV-ERB alpha and increasing BMAL1 expression. This leads to reduced skin wrinkles, increased levels of antioxidant enzymes and collagen, and improved skin structure and function.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eun-Koung An, Wei Zhang, Minseok Kwak, Peter Chang-Whan Lee, Jun-O Jin
Summary: This study found that Astragalus membranaceus polysaccharide (AMP) can activate dendritic and T cells in human blood, suggesting potential applications in regulating human immunity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Plant Sciences
Shuai Tang, Wei Liu, Qianqian Zhao, Kaidong Li, Jingyi Zhu, Wenbing Yao, Xiangdong Gao
Summary: The study found that co-administration of total polysaccharides from Astragalus membranaceus and Codonopsis pilosula could improve clinical symptoms, restore immune balance, and alleviate colonic mucosal damage in colitis mice. The unique efficacy of co-administration depended on the activation of the aryl hydrocarbon receptor (AhR) and upregulation of isovaleric acid and butyrate at specific doses.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Juan Yu, Xiao-dan Dong, Jian-shuang Jiao, Hai-yu Ji, An-jun Liu
Summary: The Astragalus membranaceus polysaccharide (APS4) shows direct cytotoxicity on various cancer cells and has potential therapeutic effects on solid tumors. Through experiments on S180 tumor-bearing mice, it was found that APS4 can regulate the immune system, inhibit solid tumor growth, and promote apoptosis of tumor cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Plant Sciences
Aliya Sheik, Kwanwoo Kim, Ganji Lakshmi Varaprasad, Hoomin Lee, Suheon Kim, Eunsu Kim, Jin-Yong Shin, Seo Yeong Oh, Yun Suk Huh
Summary: Astragalus membranaceus, as a traditional herb with a long history in cancer treatment, has attracted researchers' attention for its immunomodulatory effects and potential in alleviating cancer-related fatigue. Its natural phytoconstituents show high anti-cancer activity and have been studied in clinical trials for overcoming the toxic effects of chemotherapy drugs.
Article
Plant Sciences
Li Xiang, Yue Gao, Shiyu Chen, Jiayi Sun, Jiasi Wu, Xianli Meng
Summary: This review summarizes the pharmacological effects and molecular mechanisms of Scutellaria baicalensis in lung cancer therapy. Scutellaria baicalensis and its constituents exhibit multiple anti-cancer mechanisms against lung cancer and show high antitumor efficacy and safety in animal models.
Article
Computer Science, Artificial Intelligence
Min Shi, Yufei Tang, Xingquan Zhu
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2020)
Article
Computer Science, Information Systems
Shuliang Wang, Qi Li, Chuanfeng Zhao, Xingquan Zhu, Hanning Yuan, Tianru Dai
Summary: Peak clustering, a density based clustering method, has shortcomings in finding cluster centers in low density clusters and detecting normal points as noises. Extreme clustering, which identifies density extreme points and introduces a noise detection module, overcomes these drawbacks and improves performance significantly.
INFORMATION SCIENCES
(2021)
Article
Parasitology
Sen Li, Yang Zou, Xue-Liang Zhang, Ping Wang, Xiao-Qing Chen, Xing-Quan Zhu
KOREAN JOURNAL OF PARASITOLOGY
(2020)
Article
Immunology
Yang Zou, Wen-Bin Yang, Feng-Cai Zou, Rui-Qing Lin, Xing-Quan Zhu, Jun-Ling Hou
Summary: This study investigated the prevalence and subtypes of Blastocystis infections in farmed pigs in southern China, with ST5 being the predominant subtype. Factors such as gender, age, and region were considered as risk factors associated with Blastocystis infection in farmed pigs. This study provided valuable data for the control of Blastocystis infections in pigs, other animals, and humans in China.
MICROBIAL PATHOGENESIS
(2021)
Article
Computer Science, Theory & Methods
Zhabiz Gharibshah, Xingquan Zhu
Summary: This survey provides a comprehensive review of user response prediction in online advertising and related recommender applications. It covers the ecosystem, stakeholders, data availability, and prediction methods in online advertising platforms. A taxonomy is proposed to categorize machine learning methods used in different online platforms, and applications and resources in the field are also reviewed.
ACM COMPUTING SURVEYS
(2022)
Article
Immunology
Xia-Xia Liang, Yang Zou, Tao-Shan Li, Hong Chen, Sha-Sha Wang, Fu-Qiong Cao, Jian-Fa Yang, Xiao-Lin Sun, Xing-Quan Zhu, Feng-Cai Zou
Summary: This study investigated the prevalence and characterization of Giardia duodenalis and Cryptosporidium spp. in Yunling cattle in Yunnan province, China. The overall prevalence of G. duodenalis was 10.49% and Cryptosporidium spp. was 0.77%. Age was identified as a risk factor for G. duodenalis infection in Yunling cattle. Two assemblages of G. duodenalis and two species of Cryptosporidium were identified using nested PCR methods. This study provides baseline data for further research on the prevalence, genetic identity, and public health implications of these parasites in Yunling cattle.
MICROBIAL PATHOGENESIS
(2021)
Article
Microbiology
Yu-Gui Wang, Yang Zou, Ze-Zhong Yu, Dan Chen, Bin-Ze Gui, Jian-Fa Yang, Xing-Quan Zhu, Guo-Hua Liu, Feng-Cai Zou
Summary: This study investigated the prevalence and genotypes of Giardia duodenalis, Enterocytozoon bieneusi, and Cryptosporidium spp. in pet dogs and cats in Yunnan province, southwestern China. The results showed a higher prevalence and genetic diversity in dogs compared to cats, with potential zoonotic threats posed by both pet dogs and cats.
Article
Mathematical & Computational Biology
Magdalyn E. Elkin, Xingquan Zhu
Summary: Clinical trials are essential for medical advancement, but there is limited analysis of the valuable data from ClinicalTrials.gov. This study uses network analysis to understand infectious disease clinical trials, focusing on summarizing research areas and recommending clinical trials to sponsors.
NETWORK MODELING AND ANALYSIS IN HEALTH INFORMATICS AND BIOINFORMATICS
(2021)
Article
Genetics & Heredity
Meilin Hao, Juncai Jiang, Yongyun Zhang, Shaoqing Wang, Guowen Fu, Fengcai Zou, Yuxiao Xie, Sumei Zhao, Weizhen Li
Summary: This study utilized RNA-seq to analyze the mammary tissue transcriptomics of water buffalo with different milk fat phenotypes, revealing differentially expressed genes (DEGs). The results indicated similar gene expression patterns between high and medium fat buffalo, with the identified DEGs involved in milk protein and fat synthesis as well as immune response.
Article
Computer Science, Artificial Intelligence
Youxi Wu, Meng Geng, Yan Li, Lei Guo, Zhao Li, Philippe Fournier-Viger, Xingquan Zhu, Xindong Wu
Summary: Nonoverlapping sequential pattern mining aims at identifying repetitive patterns in a set of discrete sequences. Compared with overlapping patterns, nonoverlapping patterns have stricter constraints on occurrences and meet the Apriori property. This paper proposes an efficient algorithm for mining high average utility nonoverlapping sequential patterns, demonstrating its efficiency and superiority through experiments.
KNOWLEDGE-BASED SYSTEMS
(2021)
Article
Agriculture, Dairy & Animal Science
Hai-Yang Song, Kai-Sheng Wang, Jian-Fa Yang, Hua-Ming Mao, Li-Hua Pu, Yang Zou, Jun Ma, Xing-Quan Zhu, Feng-Cai Zou, Jun-Jun He
Summary: This study reported the prevalence and genotype distribution of Enterocytozoon bieneusi in dairy cattle in Yunnan province, China, identifying two novel zoonotic potential genotypes. Despite the low prevalence in dairy cattle, they may still pose a risk for transmitting E. bieneusi to humans. These findings are crucial for the development of effective prevention strategies for microsporidiosis.
Proceedings Paper
Computer Science, Information Systems
Shuwen Wang, Magdalyn E. Elkin, Xingquan Zhu
11TH IEEE INTERNATIONAL CONFERENCE ON KNOWLEDGE GRAPH (ICKG 2020)
(2020)
Proceedings Paper
Computer Science, Information Systems
Zhabiz Gharibshah, Xingquan Zhu
11TH IEEE INTERNATIONAL CONFERENCE ON KNOWLEDGE GRAPH (ICKG 2020)
(2020)
Proceedings Paper
Computer Science, Information Systems
Lukasz Chmielewski, Rafina Amin, Anak Wannaphaschaiyong, Xingquan Zhu
11TH IEEE INTERNATIONAL CONFERENCE ON KNOWLEDGE GRAPH (ICKG 2020)
(2020)
Article
Computer Science, Information Systems
Zhabiz Gharibshah, Xingquan Zhu, Arthur Hainline, Michael Conway
DATA SCIENCE AND ENGINEERING
(2020)