The critical molecular interconnections in regulating apoptosis and autophagy

ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells

(2015) Jing-Hong Chen et al.   Autophagy

Cancer-type-specific crosstalk between autophagy, necroptosis and apoptosis as a pharmacological target

(2015) Flavia Radogna et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of AMPK accentuates prolonged caloric restriction-induced change in cardiac contractile function through disruption of compensatory autophagy

(2015) Qijun Zheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy

(2015) Yu-Chin Su et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors

(2015) Theresa D. Carr et al.   CARCINOGENESIS

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation

(2015) Juan Xiao et al.   GENES & DEVELOPMENT

Fascaplysin Induces Caspase Mediated Crosstalk Between Apoptosis and Autophagy Through the Inhibition of PI3K/AKT/mTOR Signaling Cascade in Human Leukemia HL-60 Cells

(2015) Suresh Kumar et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Downregulation of angiogenin inhibits the growth and induces apoptosis in human bladder cancer cells through regulating AKT/mTOR signaling pathway

(2015) Jing Shu et al.   JOURNAL OF MOLECULAR HISTOLOGY

Nephrin, a transmembrane protein, is involved in pancreatic beta-cell survival signaling

(2015) Katerina Kapodistria et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

P62 regulates resveratrol-mediated Fas/Cav-1 complex formation and transition from autophagy to apoptosis

(2015) Jun Zhang et al.   Oncotarget

Isogambogenic acid induces apoptosis-independent autophagic cell death in human non-small-cell lung carcinoma cells

(2015) Jianhong Yang et al.   Scientific Reports

Ursolic Acid Attenuates Diabetic Mesangial Cell Injury through the Up-Regulation of Autophagy via miRNA-21/PTEN/Akt/mTOR Suppression

(2015) Xinxing Lu et al.   PLoS One

Dual Role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation

(2014) Yongjie Wei et al.   Autophagy

A nonapoptotic role for CASP2/caspase 2

(2014) Meenakshi Tiwari et al.   Autophagy

Inhibition of autophagy enhances the anticancer activity of silver nanoparticles

(2014) Jun Lin et al.   Autophagy

2-Hydroxyethyl methacrylate-induced apoptosis through the ATM- and p53-dependent intrinsic mitochondrial pathway

(2014) Helmut Schweikl et al.   BIOMATERIALS

Inhibition of p53 increases chemosensitivity to 5-FU in nutrient-deprived hepatocarcinoma cells by suppressing autophagy

(2014) Xian-ling Guo et al.   CANCER LETTERS

Caspase-1 Cleavage of the TLR Adaptor TRIF Inhibits Autophagy and β-Interferon Production during Pseudomonas aeruginosa Infection

(2014) Majid Sakhi Jabir et al.   Cell Host & Microbe

Hsp90 inhibitor 17-AAG sensitizes Bcl-2 inhibitor (-)-gossypol by suppressing ERK-mediated protective autophagy and Mcl-1 accumulation in hepatocellular carcinoma cells

(2014) Bin Wang et al.   EXPERIMENTAL CELL RESEARCH

HCC cells with high levels of Bcl-2 are resistant to ABT-737 via activation of the ROS–JNK–autophagy pathway

(2014) Zhenhong Ni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Coxsackievirus B3 induces crosstalk between autophagy and apoptosis to benefit its release after replicating in autophagosomes through a mechanism involving caspase cleavage of autophagy-related proteins

(2014) Le Xin et al.   INFECTION GENETICS AND EVOLUTION

Long Non-coding RNA URHC Regulates Cell Proliferation and Apoptosis via ZAK through the ERK/MAPK Signaling Pathway in Hepatocellular Carcinoma

(2014) Wei-Hua Xu et al.   International Journal of Biological Sciences

Pigment Epithelial-derived Factor (PEDF)-triggered Lung Cancer Cell Apoptosis Relies on p53 Protein-driven Fas Ligand (Fas-L) Up-regulation and Fas Protein Cell Surface Translocation

(2014) Lei Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beclin-1-p53 interaction is crucial for cell fate determination in embryonal carcinoma cells

(2014) Rakshamani Tripathi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Justicidin A-Induced Autophagy Flux Enhances Apoptosis of Human Colorectal Cancer Cells via Class III PI3K and Atg5 Pathway

(2014) Shen-Jeu Won et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Granzyme B–Activated p53 Interacts with Bcl-2 To Promote Cytotoxic Lymphocyte–Mediated Apoptosis

(2014) Thouraya Ben Safta et al.   JOURNAL OF IMMUNOLOGY

Oridonin phosphate-induced autophagy effectively enhances cell apoptosis of human breast cancer cells

(2014) Yue Li et al.   MEDICAL ONCOLOGY

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The DNA-binding domain mediates both nuclear and cytosolic functions of p53

(2014) Ariele Viacava Follis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase

(2014) C Xu et al.   ONCOGENE

Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak

(2014) L. M. Lindqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

(2014) K. G. Lassen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy

(2014) S. Sebti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rotenone Induction of Hydrogen Peroxide Inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E Pathways, Leading to Neuronal Apoptosis

(2014) Qian Zhou et al.   TOXICOLOGICAL SCIENCES

Magnetic iron oxide nanoparticles induce autophagy preceding apoptosis through mitochondrial damage and ER stress in RAW264.7 cells

(2014) Eun-Jung Park et al.   TOXICOLOGY IN VITRO

Zinc oxide nanoparticles induce apoptosis by enhancement of autophagy via PI3K/Akt/mTOR inhibition

(2014) Ruchi Roy et al.   TOXICOLOGY LETTERS

ROS inhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53 in selenite-treated NB4 cells

(2014) Y Ci et al.   Cell Death & Disease

Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells

(2014) Betty Yuen Kwan Law et al.   Scientific Reports

Tumor Suppression and Promotion by Autophagy

(2014) Yenniffer Ávalos et al.   Biomed Research International

Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma

(2013) Laurence Lamy et al.   CANCER CELL

Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling

(2013) Franziska Wachter et al.   Cell Communication and Signaling

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

(2013) D. Kenzelmann Broz et al.   GENES & DEVELOPMENT

Caspase 1 Activation Is Protective against Hepatocyte Cell Death by Up-regulating Beclin 1 Protein and Mitochondrial Autophagy in the Setting of Redox Stress

(2013) Qian Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deacetylation of p53 induces autophagy by suppressing Bmf expression

(2013) Amelia U. Contreras et al.   JOURNAL OF CELL BIOLOGY

Specific Acetylation of p53 by HDAC Inhibition Prevents DNA Damage-Induced Apoptosis in Neurons

(2013) C. Brochier et al.   JOURNAL OF NEUROSCIENCE

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Suppression of AKT Anti-Apoptotic Signaling by a Novel Drug Candidate Results in Growth Arrest and Apoptosis of Hepatocellular Carcinoma Cells

(2013) Andrea Cuconati et al.   PLoS One

Interleukin-1β in innate inflammation, autophagy and immunity

(2013) Leo A.B. Joosten et al.   SEMINARS IN IMMUNOLOGY

Role of the Crosstalk between Autophagy and Apoptosis in Cancer

(2013) Minfei Su et al.   Journal of Oncology

Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage

(2012) Monika Kusio-Kobialka et al.   APOPTOSIS

Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death

(2012) Ozlem Oral et al.   APOPTOSIS

Calpain, Atg5 and Bak play important roles in the crosstalk between apoptosis and autophagy induced by influx of extracellular calcium

(2012) Mei Shi et al.   APOPTOSIS

Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan

(2012) Sören Mai et al.   Autophagy

The p53 mRNA-Mdm2 Interaction Controls Mdm2 Nuclear Trafficking and Is Required for p53 Activation following DNA Damage

(2012) Madhavsai Gajjar et al.   CANCER CELL

The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2/Beclin 1 interaction in human glioma U251 cells

(2012) Jia-teng Zhong et al.   CANCER LETTERS

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

A Two-Step Mechanism for Cell Fate Decision by Coordination of Nuclear and Mitochondrial p53 Activities

(2012) Xiao-Jun Tian et al.   PLoS One

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation

(2011) Libin Shang et al.   Autophagy

p53 signaling and autophagy in cancer: A revolutionary strategy could be developed for cancer treatment

(2011) Xinbing Sui et al.   Autophagy

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

(2011) Shinji Saiki et al.   Autophagy

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

(2011) Colleen A. Brady et al.   CELL

Activation of mTORC2 by Association with the Ribosome

(2011) Vittoria Zinzalla et al.   CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200

(2011) Eugenia Morselli et al.   CELL CYCLE

Cell death by autophagy: facts and apparent artefacts

(2011) D Denton et al.   CELL DEATH AND DIFFERENTIATION

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

The Bcl-2-Beclin 1 interaction in (-)-gossypol-induced autophagy versus apoptosis in prostate cancer cells

(2010) Jiqin Lian et al.   Autophagy

The molecular mechanism of mitochondria autophagy in yeast

(2010) Tomotake Kanki et al.   MOLECULAR MICROBIOLOGY

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis

(2009) V. M. S. Betin et al.   JOURNAL OF CELL SCIENCE

Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells

(2008) Dong-Hyung Cho et al.   CANCER LETTERS

Histone deacetylase activity in conjunction with E2F-1 and p53 regulates Apaf-1 expression in 661W cells and the retina

(2008) Deborah M. Wallace et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY