ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis

Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice

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Caspase-2 as a tumour suppressor

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Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease

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Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice

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PIDDosome-independent tumor suppression by Caspase-2

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Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability

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CHOP Potentially Co-Operates with FOXO3a in Neuronal Cells to Regulate PUMA and BIM Expression in Response to ER Stress

(2012) Arindam P. Ghosh et al.   PLoS One

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum

(2011) M. H. Smith et al.   SCIENCE

Caspase-2 activation in the absence of PIDDosome formation

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MEK/ERK-Mediated Phosphorylation of Bim Is Required to Ensure Survival of T and B Lymphocytes during Mitogenic Stimulation

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A tumor suppressor function for caspase-2

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Caspase-2 Cleavage of BID Is a Critical Apoptotic Signal Downstream of Endoplasmic Reticulum Stress

(2008) J.-P. Upton et al.   MOLECULAR AND CELLULAR BIOLOGY

Caspase-2 is required for cell death induced by cytoskeletal disruption

(2008) L H Ho et al.   ONCOGENE

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY