The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases

Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response

(2018) Amy H. Andreotti et al.   Annual Review of Immunology

A Catalytically Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation

(2018) Yilin Meng et al.   JOURNAL OF MOLECULAR BIOLOGY

Src signaling in a low-complexity unicellular kinome

(2018) Hiroshi Suga et al.   Scientific Reports

Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen

(2018) Neel H Shah et al.   eLife

Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase

(2017) Barbara Taskinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45

(2017) Adam H. Courtney et al.   MOLECULAR CELL

Ability of Bruton’s Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling

(2017) Andrew T. Bender et al.   MOLECULAR PHARMACOLOGY

The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1

(2017) Andrew A. Wylie et al.   NATURE

Atomic view of the energy landscape in the allosteric regulation of Abl kinase

(2017) Tamjeed Saleh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Unique Domain Forms a Fuzzy Intramolecular Complex in Src Family Kinases

(2017) Miguel Arbesú et al.   STRUCTURE

Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts

(2017) Raji E. Joseph et al.   STRUCTURE

Atomic view of the energy landscape in the allosteric regulation of Abl kinase

(2017) Tamjeed Saleh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A switch in nucleotide affinity governs activation of the Src and Tec family kinases

(2017) Freia von Raußendorf et al.   Scientific Reports

Identification and characterization of activating ABL1 1b kinase mutations: impact on sensitivity to ATP-competitive and allosteric ABL1 inhibitors

(2016) B J Lee et al.   LEUKEMIA

A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli

(2016) Zachary B Katz et al.   NATURE IMMUNOLOGY

A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation

(2016) E Grassilli et al.   ONCOGENE

From identification of the BTK kinase to effective management of leukemia

(2016) C I E Smith   ONCOGENE

Transition path theory analysis of c-Src kinase activation

(2016) Yilin Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor

(2016) Neel H Shah et al.   eLife

Crystal structure of an SH2–kinase construct of c-Abl and effect of the SH2 domain on kinase activity

(2015) Sonja Lorenz et al.   BIOCHEMICAL JOURNAL

EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src

(2015) Michael J Begley et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Using ancient protein kinases to unravel a modern cancer drug's mechanism

(2015) C. Wilson et al.   SCIENCE

The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway

(2015) Hanna Sjölin-Goodfellow et al.   Science Signaling

Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases

(2015) Qifang Xu et al.   Science Signaling

Dynamics-Driven Allostery in Protein Kinases

(2015) Alexandr P. Kornev et al.   TRENDS IN BIOCHEMICAL SCIENCES

A dynamically coupled allosteric network underlies binding cooperativity in Src kinase

(2015) Zachariah H. Foda et al.   Nature Communications

EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src

(2015) Michael J Begley et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate

(2015) Qi Wang et al.   eLife

The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway

(2015) Hanna Sjölin-Goodfellow et al.   Science Signaling

Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases

(2015) Qifang Xu et al.   Science Signaling

Constitutive Activity in an Ancestral Form of Abl Tyrosine Kinase

(2015) Saadat U. Aleem et al.   PLoS One

Regulation of Src and Csk Nonreceptor Tyrosine Kinases in the Filasterean Ministeria vibrans

(2014) Kira P. Schultheiss et al.   BIOCHEMISTRY

SH2-Catalytic Domain Linker Heterogeneity Influences Allosteric Coupling across the SFK Family

(2014) A. C. Register et al.   BIOCHEMISTRY

A Conserved Isoleucine Maintains the Inactive State of Bruton's Tyrosine Kinase

(2014) Scott E. Boyken et al.   JOURNAL OF MOLECULAR BIOLOGY

Global Analysis of Human Nonreceptor Tyrosine Kinase Specificity Using High-Density Peptide Microarrays

(2014) Yang Deng et al.   JOURNAL OF PROTEOME RESEARCH

The Capable ABL: What Is Its Biological Function?

(2014) J. Y. J. Wang   MOLECULAR AND CELLULAR BIOLOGY

Energetic dissection of Gleevec's selectivity toward human tyrosine kinases

(2014) Roman V Agafonov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In vitro membrane reconstitution of the T-cell receptor proximal signaling network

(2014) Enfu Hui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Resistance Mechanisms for the Bruton's Tyrosine Kinase Inhibitor Ibrutinib

(2014) Jennifer A. Woyach et al.   NEW ENGLAND JOURNAL OF MEDICINE

The SH2 domain of Abl kinases regulates kinase autophosphorylation by controlling activation loop accessibility

(2014) Allan Joaquim Lamontanara et al.   Nature Communications

Activation pathway of Src kinase reveals intermediate states as targets for drug design

(2014) Diwakar Shukla et al.   Nature Communications

Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2

(2014) Adelajda Zorba et al.   eLife

The Genomic and Cellular Foundations of Animal Origins

(2013) Daniel J. Richter et al.   Annual Review of Genetics

Locking the Active Conformation of c-Src Kinase through the Phosphorylation of the Activation Loop

(2013) Yilin Meng et al.   JOURNAL OF MOLECULAR BIOLOGY

Earliest Holozoan Expansion of Phosphotyrosine Signaling

(2013) Hiroshi Suga et al.   MOLECULAR BIOLOGY AND EVOLUTION

Evolutionary biochemistry: revealing the historical and physical causes of protein properties

(2013) Michael J. Harms et al.   NATURE REVIEWS GENETICS

Explaining why Gleevec is a specific and potent inhibitor of Abl kinase

(2013) Y.-L. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation Loop Dynamics Determine the Different Catalytic Efficiencies of B Cell- and T Cell-Specific Tec Kinases

(2013) R. E. Joseph et al.   Science Signaling

Deciphering the Structural Basis of Eukaryotic Protein Kinase Regulation

(2013) Hiruy S. Meharena et al.   PLOS BIOLOGY

Lack of Csk-Mediated Negative Regulation in a Unicellular Src Kinase

(2012) Kira P. Schultheiss et al.   BIOCHEMISTRY

Mechanisms of resistance to BCR-ABL and other kinase inhibitors

(2012) Allan Joaquim Lamontanara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Genomic Survey of Premetazoans Shows Deep Conservation of Cytoplasmic Tyrosine Kinases and Multiple Radiations of Receptor Tyrosine Kinases

(2012) H. Suga et al.   Science Signaling

Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms

(2011) Natalia Jura et al.   MOLECULAR CELL

Biochemical Mechanisms of Resistance to Small-Molecule Protein Kinase Inhibitors

(2010) Ratika Krishnamurty et al.   ACS Chemical Biology

Phosphotyrosine Signaling: Evolving a New Cellular Communication System

(2010) Wendell A. Lim et al.   CELL

Binding or Bending: Distinction of Allosteric Abl Kinase Agonists from Antagonists by an NMR-Based Conformational Assay

(2010) Wolfgang Jahnke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Amphimedon queenslandica genome and the evolution of animal complexity

(2010) Mansi Srivastava et al.   NATURE

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

(2010) Wen-I Wu et al.   PLoS One

Atomistic View of the Conformational Activation of Src Kinase Using the String Method with Swarms-of-Trajectories

(2009) Wenxun Gan et al.   BIOPHYSICAL JOURNAL

Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations

(2009) M. A. Seeliger et al.   CANCER RESEARCH

Kinome signaling through regulated protein–protein interactions in normal and cancer cells

(2009) Tony Pawson et al.   CURRENT OPINION IN CELL BIOLOGY

Tyrosine phosphorylation: thirty years and counting

(2009) Tony Hunter   CURRENT OPINION IN CELL BIOLOGY

Protein kinase inhibitors: contributions from structure to clinical compounds

(2009) Louise N. Johnson   QUARTERLY REVIEWS OF BIOPHYSICS

Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1

(2008) Xiaoling Xiong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation

(2008) Panagis Filippakopoulos et al.   CELL

Structural Basis for the Recognition of c-Src by Its Inactivator Csk

(2008) Nicholas M. Levinson et al.   CELL

Small Molecule Recognition of c-Src via the Imatinib-Binding Conformation

(2008) Arvin C. Dar et al.   CHEMISTRY & BIOLOGY

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

(2008) Jinhua Wu et al.   EMBO JOURNAL

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites

(2008) Ashley C W Pike et al.   EMBO JOURNAL

Signaling Properties of a Non-metazoan Src Kinase and the Evolutionary History of Src Negative Regulation

(2008) Wanqing Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane recognition by phospholipid-binding domains

(2008) Mark A. Lemmon   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of tyrosine kinases by mutation of the gatekeeper threonine

(2008) Mohammad Azam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A helix scaffold for the assembly of active protein kinases

(2008) A. P. Kornev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan

(2008) G. Manning et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of the phospho-tyrosine signaling machinery in premetazoan lineages

(2008) D. Pincus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A conserved protonation-dependent switch controls drug binding in the Abl kinase

(2008) Y. Shan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flexibility and charge asymmetry in the activation loop of Src tyrosine kinases

(2008) Nilesh K. Banavali et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS