Deciphering the Structural Basis of Eukaryotic Protein Kinase Regulation

Identification of a hidden strain switch provides clues to an ancient structural mechanism in protein kinases

(2013) K. Oruganty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for the Regulation of Protein Kinase A by Activation Loop Phosphorylation

(2012) Jon M. Steichen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anaplastic lymphoma kinase (ALK): Structure, oncogenic activation, and pharmacological inhibition

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms

(2011) Natalia Jura et al.   MOLECULAR CELL

Mutations in the Catalytic Loop HRD Motif Alter the Activity and Function of Drosophila Src64

(2011) Taylor C. Strong et al.   PLoS One

Biochemical Mechanisms of Resistance to Small-Molecule Protein Kinase Inhibitors

(2010) Ratika Krishnamurty et al.   ACS Chemical Biology

Crystal Structures of Anaplastic Lymphoma Kinase in Complex with ATP Competitive Inhibitors

(2010) Roberto T. Bossi et al.   BIOCHEMISTRY

Controlling the Activity of the Tec Kinase Itk by Mutation of the Phenylalanine Gatekeeper Residue

(2010) Raji E. Joseph et al.   BIOCHEMISTRY

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

(2010) Jianming Zhang et al.   NATURE

Rapid detection, classification and accurate alignment of up to a million or more related protein sequences

(2009) Andrew F. Neuwald   BIOINFORMATICS

Structural insight into the autoinhibition mechanism of AMP-activated protein kinase

(2009) Lei Chen et al.   NATURE

A chimeric mechanism for polyvalenttrans-phosphorylation of PKA by PDK1

(2009) Robert A. Romano et al.   PROTEIN SCIENCE

Activation of tyrosine kinases by mutation of the gatekeeper threonine

(2008) Mohammad Azam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A helix scaffold for the assembly of active protein kinases

(2008) A. P. Kornev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase

(2008) Chen Qiu et al.   STRUCTURE

Analogous regulatory sites within the αC-β4 loop regions of ZAP-70 tyrosine kinase and AGC kinases

(2007) Natarajan Kannan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS