A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli

SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins

(2016) Mi-Jeong Park et al.   MOLECULAR CELL

Extracting Accurate Precursor Information for Tandem Mass Spectra by RawConverter

(2015) Lin He et al.   ANALYTICAL CHEMISTRY

ProLuCID: An improved SEQUEST-like algorithm with enhanced sensitivity and specificity

(2015) T. Xu et al.   Journal of Proteomics

T cell receptor dwell times control the kinase activity of Zap70

(2015) Christian Klammt et al.   NATURE IMMUNOLOGY

Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance

(2014) Ondrej Stepanek et al.   CELL

The Actin and Tetraspanin Networks Organize Receptor Nanoclusters to Regulate B Cell Receptor-Mediated Signaling

(2013) Pieta K. Mattila et al.   IMMUNITY

Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker

(2013) Q. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells

(2013) Geoff P O'Donoghue et al.   eLife

Receptor Signaling Clusters in the Immune Synapse

(2012) Michael L. Dustin et al.   Annual Review of Biophysics

Identification of Type-II Inhibitors Using Kinase Structures

(2012) Frank Lovering et al.   Chemical Biology & Drug Design

Fast rebinding increases dwell time of Src homology 2 (SH2)-containing proteins near the plasma membrane

(2012) D. Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Nanoscale Organization of Signaling Molecules Downstream of the T Cell Antigen Receptor

(2011) Eilon Sherman et al.   IMMUNITY

Dynein-Driven Transport of T Cell Receptor Microclusters Regulates Immune Synapse Formation and T Cell Activation

(2011) Akiko Hashimoto-Tane et al.   IMMUNITY

Fine-tuning of proximal TCR signaling by ZAP-70 tyrosine residues in Jurkat cells

(2011) M. Szabo et al.   INTERNATIONAL IMMUNOLOGY

TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity

(2010) Johannes B. Huppa et al.   NATURE

Alternative modes of binding of proteins with tandem SH2 domains

(2010) Ronan O'Brien et al.   PROTEIN SCIENCE

ZAP-70: An Essential Kinase in T-cell Signaling

(2010) H. Wang et al.   Cold Spring Harbor Perspectives in Biology

Integrins in immunity

(2009) R. Evans et al.   JOURNAL OF CELL SCIENCE

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY

A Mechanism for Src Kinase-Dependent Signaling by Noncatalytic Receptors†

(2008) Jonathan A. Cooper et al.   BIOCHEMISTRY

Tyr130 phosphorylation triggers Syk release from antigen receptor by long-distance conformational uncoupling

(2008) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA