The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway

Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development

(2014) Byron B Au-Yeung et al.   NATURE IMMUNOLOGY

In vitro membrane reconstitution of the T-cell receptor proximal signaling network

(2014) Enfu Hui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A sharp T-cell antigen receptor signaling threshold for T-cell proliferation

(2014) B. B. Au-Yeung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens

(2013) Judith N. Mandl et al.   IMMUNITY

Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker

(2013) Q. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling

(2013) Ying Xim Tan et al.   NATURE IMMUNOLOGY

ERK Positive Feedback Regulates a Widespread Network of Tyrosine Phosphorylation Sites across Canonical T Cell Signaling and Actin Cytoskeletal Proteins in Jurkat T Cells

(2013) Ynes A. Helou et al.   PLoS One

Quantitative Phosphoproteome Analysis Unveils LAT as a Modulator of CD3ζ and ZAP-70 Tyrosine Phosphorylation

(2013) Mogjiborahman Salek et al.   PLoS One

Sequence-specific determination of protein and peptide concentrations by absorbance at 205 nm

(2013) Nicholas J. Anthis et al.   PROTEIN SCIENCE

Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases

(2013) S. Mukherjee et al.   Science Signaling

Systems Model of T Cell Receptor Proximal Signaling Reveals Emergent Ultrasensitivity

(2013) Himadri Mukhopadhyay et al.   PLoS Computational Biology

Non-catalytic tyrosine-phosphorylated receptors

(2012) Omer Dushek et al.   IMMUNOLOGICAL REVIEWS

Structural and Biophysical Characterization of the Syk Activation Switch

(2012) Ulrich Grädler et al.   JOURNAL OF MOLECULAR BIOLOGY

The Membrane Environment Can Promote or Suppress Bistability in Cell Signaling Networks

(2012) Steven M. Abel et al.   JOURNAL OF PHYSICAL CHEMISTRY B

CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation

(2012) Nataly Manjarrez-Orduño et al.   NATURE GENETICS

Quantitative Phosphoproteomics Reveals SLP-76 Dependent Regulation of PAG and Src Family Kinases in T Cells

(2012) Lulu Cao et al.   PLoS One

Basal LAT-diacylglycerol-RasGRP1 Signals in T Cells Maintain TCRα Gene Expression

(2011) Evan Markegard et al.   PLoS One

Feedback Circuits Monitor and Adjust Basal Lck-Dependent Events in T Cell Receptor Signaling

(2011) J. R. Schoenborn et al.   Science Signaling

CD45-Csk Phosphatase-Kinase Titration Uncouples Basal and Inducible T Cell Receptor Signaling during Thymic Development

(2010) Julie Zikherman et al.   IMMUNITY

Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction

(2010) Konstantina Nika et al.   IMMUNITY

A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity

(2010) Byron B Au-Yeung et al.   NATURE IMMUNOLOGY

Fast on-rates allow short dwell time ligands to activate T cells

(2010) C. C. Govern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery

(2010) M. N. Artyomov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HTAPP: High-throughput autonomous proteomic pipeline

(2010) Kebing Yu et al.   PROTEOMICS

ITAM-mediated Signaling by the T-Cell Antigen Receptor

(2010) P. E. Love et al.   Cold Spring Harbor Perspectives in Biology

Understanding the Structure and Function of the Immunological Synapse

(2010) M. L. Dustin et al.   Cold Spring Harbor Perspectives in Biology

ZAP-70: An Essential Kinase in T-cell Signaling

(2010) H. Wang et al.   Cold Spring Harbor Perspectives in Biology

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

T-cell receptor signaling is mediated by transient Lck activity, which is inhibited by inorganic mercury

(2009) Stamatina E. Ziemba et al.   FASEB JOURNAL

CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells

(2009) Michelle L. Hermiston et al.   IMMUNOLOGICAL REVIEWS

SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels

(2009) Ulrike Lorenz   IMMUNOLOGICAL REVIEWS

The structure, regulation, and function of ZAP-70

(2009) Byron B. Au-Yeung et al.   IMMUNOLOGICAL REVIEWS

The roles of Dok family adapters in immunoreceptor signaling

(2009) Ryuichi Mashima et al.   IMMUNOLOGICAL REVIEWS

A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity

(2009) Lih-Yun Hsu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A New Approach for Quantitative Phosphoproteomic Dissection of Signaling Pathways Applied to T Cell Receptor Activation

(2009) Vinh Nguyen et al.   MOLECULAR & CELLULAR PROTEOMICS

Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response

(2009) S. Deindl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated platform for manual and high-throughput statistical validation of tandem mass spectra

(2009) Kebing Yu et al.   PROTEOMICS

PeptideDepot: Flexible relational database for visual analysis of quantitative proteomic data and integration of existing protein information

(2009) Kebing Yu et al.   PROTEOMICS

Negative regulation of lymphocyte development and function by the Cbl family of proteins

(2008) Fang Huang et al.   IMMUNOLOGICAL REVIEWS

Inhibition of ZAP-70 Kinase Activity via an Analog-sensitive Allele Blocks T Cell Receptor and CD28 Superagonist Signaling

(2008) Susan E. Levin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanism of the Syk Activation Switch

(2008) Emily Tsang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY