The ascending pathophysiology of cholestatic liver disease

Metabolic preconditioning protects BSEP / ABCB11 −/− mice against cholestatic liver injury

(2017) Claudia D. Fuchs et al.   JOURNAL OF HEPATOLOGY

BAT117213: Ileal bile acid transporter (IBAT) inhibition as a treatment for pruritus in primary biliary cirrhosis: study protocol for a randomised controlled trial

(2016) Vinod S. Hegade et al.   BMC GASTROENTEROLOGY

Long-Term Fenofibrate Treatment in Primary Biliary Cholangitis Improves Biochemistry but Not the UK-PBC Risk Score

(2016) Vinod S. Hegade et al.   DIGESTIVE DISEASES AND SCIENCES

Prevalence of Sclerosing Cholangitis Detected by Magnetic Resonance Cholangiography in Patients With Long-term Inflammatory Bowel Disease

(2016) Aida Kapic Lunder et al.   GASTROENTEROLOGY

CD14 is associated with biliary stricture formation

(2016) Kilian Friedrich et al.   HEPATOLOGY

Liver kinase B1 regulates hepatocellular tight junction distribution and functionin vivo

(2016) Natalie Porat-Shliom et al.   HEPATOLOGY

Immunoglobulin G4+B-cell receptor clones distinguish immunoglobulin G 4-related disease from primary sclerosing cholangitis and biliary/pancreatic malignancies

(2016) Marieke E. Doorenspleet et al.   HEPATOLOGY

Cholestasis-induced adaptive remodeling of interlobular bile ducts

(2016) Nachiket Vartak et al.   HEPATOLOGY

Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis

(2016) Anna Baghdasaryan et al.   JOURNAL OF HEPATOLOGY

Hepatobiliary Secretion Kinetics of Conjugated Bile Acids Measured in Pigs by 11C-Cholylsarcosine PET

(2016) M. Sorensen et al.   JOURNAL OF NUCLEAR MEDICINE

Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis

(2016) Serge J. Zweers et al.   LIVER INTERNATIONAL

Simtuzumab treatment of advanced liver fibrosis in HIV and HCV-infected adults: results of a 6-month open-label safety trial

(2016) Eric G. Meissner et al.   LIVER INTERNATIONAL

Alkaline phosphatase at diagnosis of primary sclerosing cholangitis and 1 year later: evaluation of prognostic value

(2016) Elisabeth M. G. de Vries et al.   LIVER INTERNATIONAL

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

(2016) David Ellinghaus et al.   NATURE GENETICS

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

(2016) Frederik Nevens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

(2016) H. Chu et al.   SCIENCE

Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs

(2016) Ahmad Sharanek et al.   Scientific Reports

Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis

(2016) Eric Lefebvre et al.   PLoS One

Bile canalicular dynamics in hepatocyte sandwich cultures

(2015) Raymond Reif et al.   ARCHIVES OF TOXICOLOGY

Mathematical modelling of fluid transport and its regulation at multiple scales

(2015) Osvaldo Chara et al.   BIOSYSTEMS

Potential of nor-Ursodeoxycholic Acid in Cholestatic and Metabolic Disorders

(2015) Michael Trauner et al.   DIGESTIVE DISEASES

Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid

(2015) Gideon M. Hirschfield et al.   GASTROENTEROLOGY

Pharmacological inhibition of apical sodium-dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice

(2015) Alexander G. Miethke et al.   HEPATOLOGY

Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na+-taurocholate cotransporting polypeptide knockout mice

(2015) Davor Slijepcevic et al.   HEPATOLOGY

Engineered fibroblast growth factor 19 reduces liver injury and resolves sclerosing cholangitis in Mdr2 -deficient mice

(2015) Mei Zhou et al.   HEPATOLOGY

New paradigms in the treatment of hepatic cholestasis: From UDCA to FXR, PXR and beyond

(2015) Ulrich Beuers et al.   JOURNAL OF HEPATOLOGY

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

(2015) Philippe Goyette et al.   NATURE GENETICS

Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis

(2015) Benjamin L. Woolbright et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

(2015) Heather J. Cordell et al.   Nature Communications

Farnesoid X receptor associates with β-catenin and inhibits its activity in hepatocellular carcinoma

(2015) Xijun Liu et al.   Oncotarget

Loss of CD28 Expression by Liver-Infiltrating T Cells Contributes to Pathogenesis of Primary Sclerosing Cholangitis

(2014) Evaggelia Liaskou et al.   GASTROENTEROLOGY

Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated hypercholanemia without a clear clinical phenotype

(2014) Frédéric M. Vaz et al.   HEPATOLOGY

Characterization of animal models for primary sclerosing cholangitis (PSC)

(2014) Peter Fickert et al.   JOURNAL OF HEPATOLOGY

Hepatobiliary manifestations of ulcerative colitis: an example of gut-liver crosstalk

(2014) U. Navaneethan   Gastroenterology Report

Randomised clinical trial: vancomycin or metronidazole in patients with primary sclerosing cholangitis - a pilot study

(2013) J. H. Tabibian et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis

(2013) H. Tanaka et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

β1 integrin is a long-sought sensor for tauroursodeoxycholic acid

(2013) Ulrich Beuers   HEPATOLOGY

Differential effects of norUDCA and UDCA in obstructive cholestasis in mice

(2013) Peter Fickert et al.   JOURNAL OF HEPATOLOGY

Chronic cholestatic liver diseases: Clues from histopathology for pathogenesis

(2013) Marion J. Pollheimer et al.   MOLECULAR ASPECTS OF MEDICINE

α5β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes

(2012) Holger Gohlke et al.   HEPATOLOGY

Therapeutic effect of cytotoxic T lymphocyte antigen 4/immunoglobulin on a murine model of primary biliary cirrhosis

(2012) Amy Dhirapong et al.   HEPATOLOGY

Bile acid transporters and regulatory nuclear receptors in the liver and beyond

(2012) Emina Halilbasic et al.   JOURNAL OF HEPATOLOGY

Bile Acids Induce Inflammatory Genes in Hepatocytes

(2011) Katryn Allen et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of epithelial permeability by the actin cytoskeleton

(2011) Laurel S. Rodgers et al.   Cytoskeleton

Metabolomic profiling of 17 bile acids in serum from patients with primary biliary cirrhosis and primary sclerosing cholangitis: A pilot study

(2011) Jocelyn Trottier et al.   DIGESTIVE AND LIVER DISEASE

Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2 −/− (Abcb4 −/− ) mouse cholangiopathy model by promoting biliary HCO 3− output

(2011) Anna Baghdasaryan et al.   HEPATOLOGY

Optimality of the Munch mechanism for translocation of sugars in plants

(2011) K. H. Jensen et al.   Journal of the Royal Society Interface

Effect of bile duct ligation on bile acid composition in mouse serum and liver

(2011) Youcai Zhang et al.   LIVER INTERNATIONAL

Ursodeoxycholic Acid Is Conjugated with Taurine to Promote Secretin-Stimulated Biliary Hydrocholeresis in the Normal Rat

(2011) Miriam Úriz et al.   PLoS One

Liver-specific β-catenin knockout mice have bile canalicular abnormalities, bile secretory defect, and intrahepatic cholestasis

(2010) Tzu-Hsuan Yeh et al.   HEPATOLOGY

Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity

(2010) Evaggelia Liaskou et al.   HEPATOLOGY

Bezafibrate for the treatment of primary sclerosing cholangitis

(2010) Suguru Mizuno et al.   JOURNAL OF GASTROENTEROLOGY

A model for cyst lumen expansion and size regulation via fluid secretion

(2010) Elan Gin et al.   JOURNAL OF THEORETICAL BIOLOGY

α-Catenin as a tension transducer that induces adherens junction development

(2010) Shigenobu Yonemura et al.   NATURE CELL BIOLOGY

FXR Promotes Endothelial Cell Motility Through Coordinated Regulation of FAK and MMP-9

(2009) Amitava Das et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis

(2009) Keith D. Lindor et al.   HEPATOLOGY

Mouse Hepatic Portal Venoconstrictive Response to Vasoconstrictors Is Much Weaker Than That in Rat

(2009) Zhan-Sheng Zhao et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics

(2008) A. F. Hofmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis

(2008) Frank G. Schaap et al.   HEPATOLOGY