期刊
ARCHIVES OF TOXICOLOGY
卷 92, 期 10, 页码 2981-2986出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00204-018-2297-6
关键词
Hepatocyte; In vitro system; Viability; Morphology; Functionality; Toxicity
类别
资金
- European Research Council (ERC)
- Fund for Scientific Research Flanders-Belgium (FWO)
- University Hospital of the Vrije Universiteit Brussel-Belgium (Willy Gepts Fonds UZ-VUB)
- Center for Alternatives to Animal Testing (CAAT) at Johns Hopkins University Baltimore-USA
A plethora of human hepatocyte-based in vitro systems for toxicity testing has been developed over the past few years. These systems are either directly derived from liver tissue or have been generated through stem cell technology. A wide variety of parameters is currently used to demonstrate the acquisition of in vivo-like hepatocellular physiology and toxicity in such novel in vitro systems. This frequently leads to flawed claims regarding applicability and may impede comparison between in vitro systems. A possible solution lies in defining a set of consensus criteria for proper benchmarking. A proposal for characterization of hepatocyte-based in vitro systems for toxicity screening is made in this paper and consists of testing critical features of viability, morphology, functionality and toxicity.
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