Strategies for identifying synthetic peptides to act as inhibitors of NADPH oxidases, or “All that you did and did not want to know about Nox inhibitory peptides”

Studying protein–protein interactions using peptide arrays

(2011) Chen Katz et al.   CHEMICAL SOCIETY REVIEWS

NADPH oxidase inhibitors: a patent review

(2011) Jung-Ae Kim et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Nox2 B-loop peptide, Nox2ds, specifically inhibits the NADPH oxidase Nox2

(2011) Gábor Csányi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of NADPH oxidase activation by peptides mapping within the dehydrogenase region of Nox2-A “peptide walking” study

(2011) Iris Dahan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

(2011) Grant R. Drummond et al.   NATURE REVIEWS DRUG DISCOVERY

Antioxidants: Molecules, medicines, and myths

(2010) John M.C. Gutteridge et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Peptide-based inhibitors of the phagocyte NADPH oxidase

(2010) Jamel El-Benna et al.   BIOCHEMICAL PHARMACOLOGY

Constitutive NADPH-Dependent Electron Transferase Activity of the Nox4 Dehydrogenase Domain

(2010) Yukio Nisimoto et al.   BIOCHEMISTRY

p47phoxMolecular Activation for Assembly of the Neutrophil NADPH Oxidase Complex

(2010) Julien Marcoux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nox4 B-loop Creates an Interface between the Transmembrane and Dehydrogenase Domains

(2010) Heather M. Jackson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Prenylated p47phox-p67phox-Rac1 Chimera Is a Quintessential NADPH Oxidase Activator

(2010) Ariel Mizrahi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small-Molecule NOX Inhibitors: ROS-Generating NADPH Oxidases as Therapeutic Targets

(2009) Vincent Jaquet et al.   ANTIOXIDANTS & REDOX SIGNALING

Advances in Peptide Pharmaceuticals

(2009) Cynthia Stevenson   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Targeting Rho GTPases by Peptidic Structures

(2009) Filippo Marchioni et al.   CURRENT PHARMACEUTICAL DESIGN

Small interfering peptide (siP) for in vivo examination of the developing lung interactonome

(2009) J. Craig Cohen et al.   DEVELOPMENTAL DYNAMICS

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

NADPH oxidase activator p67phox behaves in solution as a multidomain protein with semi-flexible linkers

(2009) Dominique Durand et al.   JOURNAL OF STRUCTURAL BIOLOGY

A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo

(2008) L. C. Cerchietti et al.   BLOOD

Discovering and improving novel peptide therapeutics

(2008) D MCGREGOR   CURRENT OPINION IN PHARMACOLOGY

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species

(2008) Hideki Sumimoto   FEBS Journal

Identification of a Conserved Rac-binding Site on NADPH Oxidases Supports a Direct GTPase Regulatory Mechanism

(2008) Yu-Ya Kao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Puzzles, promises and a cure for ageing

(2008) Jan Vijg et al.   NATURE

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

(2008) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOX enzymes as novel targets for drug development

(2008) J. David Lambeth et al.   Seminars in Immunopathology