Article
Biochemistry & Molecular Biology
Marta Massari, Callum R. Nicoll, Sara Marchese, Andrea Mattevi, Maria Laura Mascotti
Summary: This article investigates the phylogenetic analysis of the NADPH oxidase family in eukaryotes and finds that all known members share a common ancestor. Calcium-dependency is identified as the earliest form of NOX regulation, while the protein-protein mode of regulation is a more recent event generated by gene duplication.
Review
Medicine, Research & Experimental
Yawei Bi, Xiao Lei, Ningli Chai, Enqiang Linghu
Summary: NOX4 is upregulated in pancreatic cancer and primarily produces hydrogen peroxide, exhibiting different properties from other NOX family subtypes. Recent studies suggest that NOX4 promotes pancreatic cancer occurrence and development, making it a potential therapeutic target in pancreatic cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Andres Trostchansky, Marcelo Alarcon
Summary: Oxidative stress is involved in various non-communicable diseases, such as cardiovascular diseases. Excessive reactive oxygen species (ROS) formation can lead to the undesirable effects of oxidative stress. Platelets play a crucial role in arterial thrombosis, and excessive ROS formation stimulates platelet activation and aggregation. The proteins Protein Disulphide Isomerase (PDI) and NADPH oxidase (NOX) isoforms are involved in these processes. A bioinformatic analysis of their roles and interactions in platelets, as well as the signaling pathways involved, was performed. The data support the potential use of specific enzyme inhibitors or dual inhibition of these enzymes for treating diseases involving platelet dysfunction.
Article
Biochemistry & Molecular Biology
Ildiko Szanto
Summary: Cancer cells can adapt to hypoxic environments through metabolic rewiring and synthesis of antioxidant molecules. NOX4, a member of the NOX family enzymes, plays a key role in the oncogenic metabolic adaptation of cancer cells by regulating diverse metabolic processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Henrike Hoermann, Irena Krueger, Nadine Maurus, Friedrich Reusswig, Yi Sun, Christina Kohlmorgen, Maria Grandoch, Jens W. Fischer, Margitta Elvers
Summary: Biglycan plays a crucial role in hemostasis and thrombosis by binding and activating platelets through GPVI. Deficiency of biglycan results in reduced platelet adhesion to injured vessels and prolonged bleeding times.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Flavia Rezende, Pedro Felipe Malacarne, Niklas Mueller, Birgit Rathkolb, Martin Hrabe de Angelis, Katrin Schroeder, Ralf P. Brandes
Summary: The study found that Nox4 knockout mice exhibited similar weight loss and sodium sparing function under a low sodium diet, but showed reduced systolic blood pressure, heart-rate ratio, and heart to body weight ratio compared to wild-type mice, indicating that Nox4 plays a role in blood pressure regulation induced by low sodium diets.
Article
Biochemistry & Molecular Biology
Jin Han, Donghwi Park, Ji Young Park, Seungwoo Han
Summary: Increased oxidative stress in OA cartilage leads to extracellular matrix degradation and chondrocyte apoptosis. This study found that inhibiting NOX can decrease ROS production, suppress oxidative stress marker genes and catabolic proteases, and protect against OA by modulating oxidative stress and gene expression.
Article
Pharmacology & Pharmacy
Sergejs Zavadskis, Adelheid Weidinger, Dominik Hanetseder, Asmita Banerjee, Cornelia Schneider, Susanne Wolbank, Darja Marolt Presen, Andrey Kozlov
Summary: The study found that the inhibitor DPI has different effects on ROS metabolism and mitochondrial function in various types of cells, such as stem cells and differentiated cells, depending on the cell's energy metabolism. Undifferentiated cells may be a better target for DPI compared to differentiated parenchymal cells.
Article
Biochemistry & Molecular Biology
Sonia Eligini, Benedetta Porro, Giancarlo Aldini, Susanna Colli, Cristina Banfi
Summary: N-acetylcysteine (NAC) inhibits platelet aggregation by restoring mercaptoalbumin (HMA) and reducing levels of oxidized albumin, which are associated with diseases related to oxidative stress. This study also shows that cysteine can have similar effects as NAC in inhibiting platelet aggregation by restoring HMA.
Review
Immunology
Rizwana Begum, Shilpa Thota, Abubakar Abdulkadir, Gagandeep Kaur, Prathyusha Bagam, Sanjay Batra
Summary: This review provides an overview of the role of reactive oxygen species (ROS) in biological systems and the importance of NOX enzymes in antimicrobial mechanisms and disease pathophysiology. The article emphasizes on the therapeutic strategies to inhibit ROS production and highlights the significance of computational modeling in future NOX-related studies.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mariana Garces, Timoteo Marchini, Lourdes Caceres, Valeria Calabro, Andrea M. Mebert, Maria Victoria Tuttolomondo, Tamara Vico, Virginia Vanasco, Fiorella Tesan, Jimena Salgueiro, Marcela Zubillaga, Martin F. Desimone, Giuseppe Valacchi, Silvia Alvarez, Natalia D. Magnani, Pablo A. Evelson
Summary: This study aimed to investigate the toxicological mechanisms in cardiorespiratory oxidative metabolism induced by acute exposure to Ni-doped-NP. Results showed that Ni-NP mainly accumulated in the lungs, leading to increased oxidative reactions and damage to the antioxidant system, resulting in various pathological responses.
Article
Immunology
Chih-Fen Hu, San-Pin Wu, Gu-Jiun Lin, Chi-Chang Shieh, Chih-Sin Hsu, Jing-Wun Chen, Shih-Heng Chen, Jau-Shyong Hong, Shyi-Jou Chen
Summary: The study showed that Nox2 deficiency attenuates neural damage induced by EAE, reduces disease severity, pathogenic immune cells infiltration, demyelination, and oxidative stress in the CNS. It also revealed that microglial Nox2 plays a regulatory role in multiple pathways important for MS/EAE pathogenesis, suggesting that Nox2 inhibition may represent an important therapeutic target for MS.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hongxiang Jiang, Fei Li, Linzhi Cai, Qianxue Chen
Summary: NOX4 plays a role in angiogenesis in glioblastoma through ROS production, and TSPO is an upstream target of NOX4-derived mitochondrial ROS. The TSPO-NOX4 signaling pathway could serve as a potential molecular target for therapeutic strategies in glioblastoma.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yoon-Seok Seo, Jung-Min Park, Jae-Hyeong Kim, Moo-Yeol Lee
Summary: Smoking is a significant risk factor for various diseases due to the production of excessive reactive oxygen species (ROS). This review focuses on how cigarette smoke promotes the formation of ROS and provides key mechanisms involved.
Article
Cell Biology
Sara Miguel-Jimenez, Blanca Pina-Beltran, Silvia Gimeno-Martos, Melissa Carvajal-Serna, Adriana Casao, Rosaura Perez-Pe
Summary: This study found NOX5 in ram spermatozoa and demonstrated that melatonin can prevent changes related to sperm capacitation by modulating NOX5 activity. This suggests that melatonin plays a role in antioxidant defense in ram sperm by influencing NOX5 during capacitation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mareike G. Posner, Abhishek Upadhyay, Aisha Alsheikh Abubaker, Tiago M. Fortunato, Dina Vara, Ilaria Canobbio, Stefan Bagby, Giordano Pula
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Cell Biology
Aisha Alsheikh Abubaker, Dina Vara, Ian Eggleston, Ilaria Canobbio, Giordano Pula
Article
Biochemistry & Molecular Biology
Dina Vara, Joanna M. Watt, Tiago M. Fortunato, Harry Mellor, Matthew Burgess, Kate Wicks, Kimberly Mace, Shaun Reeksting, Anneke Lubben, Caroline P. D. Wheeler-Jones, Giordano Pula
ANTIOXIDANTS & REDOX SIGNALING
(2018)
Article
Biochemistry & Molecular Biology
Ilaria Canobbio, Gianni F. Guidetti, Barbara Oliviero, Dana Manganaro, Dina Vara, Mauro Torti, Giordano Pula
BIOCHEMICAL JOURNAL
(2014)
Article
Biochemistry & Molecular Biology
Ashish Gupta, Dina S. Vara, Geoffrey Punshon, Kevin M. Sales, Marc C. Winslet, Alexander M. Seifalian
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2009)
Article
Biochemistry & Molecular Biology
Geoffrey Punshon, Dina S. Vara, Kevin M. Sales, Alexander M. Seifalian
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2011)
Article
Biochemistry & Molecular Biology
Geoffrey Punshon, Dina S. Vara, Kevin M. Sales, Alexander M. Seifalian
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2011)
Article
Cardiac & Cardiovascular Systems
Giordano Pula, Ursula Mayr, Colin Evans, Marianna Prokopi, Dina S. Vara, Xiaoke Yin, Zoe Astroulakis, Qingzhong Xiao, Jonathan Hill, Qingbo Xu, Manuel Mayr
CIRCULATION RESEARCH
(2009)
Article
Medicine, Research & Experimental
D. Vara, G. Pula
CURRENT MOLECULAR MEDICINE
(2014)
Article
Multidisciplinary Sciences
Tiago M. Fortunato, Dina S. Vara, Caroline P. Wheeler-Jones, Giordano Pula
Article
Hematology
Dina S. Vara, Michelangelo Campanella, Ilaria Canobbio, Warwick B. Dunn, Giuseppe Pizzorno, Michio Hirano, Giordano Pula
THROMBOSIS AND HAEMOSTASIS
(2013)
Article
Hematology
Dina Vara, Eugenia Cifuentes-Pagano, Patrick J. Pagano, Giordano Pula
Article
Cell Biology
Aisha Alsheikh Abubaker, Dina Vara, Caterina Visconte, Ian Eggleston, Mauro Torti, Ilaria Canobbio, Giordano Pula
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Pharmacology & Pharmacy
Dina S. Vara, Geoffrey Punshon, Kevin M. Sales, George Hamilton, Alexander M. Seifalian
CURRENT VASCULAR PHARMACOLOGY
(2011)