NADPH oxidases as a source of oxidative stress and molecular target in ischemia/reperfusion injury

Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

(2012) Katrin Schröder et al.   CIRCULATION RESEARCH

Off-target thiol alkylation by the NADPH oxidase inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (VAS2870)

(2012) Qi-An Sun et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice

(2012) Norbert Weissmann et al.   Nature Communications

Moderate Caveolin-1 Downregulation Prevents NADPH Oxidase–Dependent Endothelial Nitric Oxide Synthase Uncoupling by Angiotensin II in Endothelial Cells

(2011) Irina Lobysheva et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies

(2011) Alexander Sirker et al.   BASIC RESEARCH IN CARDIOLOGY

NOX1, 2, 4, 5: counting out oxidative stress

(2011) K Wingler et al.   BRITISH JOURNAL OF PHARMACOLOGY

NADPH Oxidase 4 Promotes Endothelial Angiogenesis Through Endothelial Nitric Oxide Synthase Activation

(2011) Siobhan M. Craige et al.   CIRCULATION

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE

Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia

(2011) Guoxiang Yuan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Regulation of myocardial growth and death by NADPH oxidase

(2011) Yasuhiro Maejima et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

NADPH oxidase is involved in post-ischemic brain inflammation

(2011) Hai Chen et al.   NEUROBIOLOGY OF DISEASE

A Novel and Specific NADPH Oxidase-1 (Nox1) Small-Molecule Inhibitor Blocks the Formation of Functional Invadopodia in Human Colon Cancer Cells

(2010) Davide Gianni et al.   ACS Chemical Biology

Mitochondrial oxidant stress triggers cell death in simulated ischemia–reperfusion

(2010) Gabriel Loor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Comparative pharmacology of chemically distinct NADPH oxidase inhibitors

(2010) S Wind et al.   BRITISH JOURNAL OF PHARMACOLOGY

Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes

(2010) Tetsuro Ago et al.   CIRCULATION RESEARCH

Mechanisms Contributing to Cerebral Infarct Size after Stroke: Gender, Reperfusion, T Lymphocytes, and Nox2-Derived Superoxide

(2010) Vanessa H Brait et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

(2010) Benoı̂t Laleu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The NADPH Oxidase Subunit NOX4 Is a New Target Gene of the Hypoxia-inducible Factor-1

(2010) Isabel Diebold et al.   MOLECULAR BIOLOGY OF THE CELL

NADPH oxidase Nox1 contributes to ischemic injury in experimental stroke in mice

(2010) Timo Kahles et al.   NEUROBIOLOGY OF DISEASE

Oxidative Stress as a Mediator of Cardiovascular Disease

(2010) Maqsood M. Elahi et al.   Oxidative Medicine and Cellular Longevity

NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis

(2010) M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

(2010) J. Kuroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nox isoforms in vascular pathophysiology: insights from transgenic and knockout mouse models

(2010) Jennifer Rivera et al.   REDOX REPORT

Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

(2010) Christoph Kleinschnitz et al.   PLOS BIOLOGY

Regulated production of free radicals by the mitochondrial electron transport chain: Cardiac ischemic preconditioning☆

(2009) Satoshi Matsuzaki et al.   ADVANCED DRUG DELIVERY REVIEWS

Suppressed hindlimb perfusion in Rac2−/− and Nox2−/− mice does not result from impaired collateral growth

(2009) Matthew R. Distasi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Role of Nitric Oxide in Myocardial Repair and Remodeling

(2009) Hajime Otani   ANTIOXIDANTS & REDOX SIGNALING

The Hypoxia-Inducible Factor-2α Is Stabilized by Oxidative Stress Involving NOX4

(2009) Isabel Diebold et al.   ANTIOXIDANTS & REDOX SIGNALING

Nox2-Containing NADPH Oxidase Deficiency Confers Protection From Hindlimb Ischemia in Conditions of Increased Oxidative Stress

(2009) Paola Haddad et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NADPH Oxidases: Functions and Pathologies in the Vasculature

(2009) Bernard Lassègue et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke

(2009) Katherine A. Jackman et al.   BRAIN RESEARCH

Effects of NXY-059 in experimental stroke: an individual animal meta-analysis

(2009) PMW Bath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mouse strain determines the outcome of wound healing after myocardial infarction

(2009) Susanne W.M. van den Borne et al.   CARDIOVASCULAR RESEARCH

Poldip2, a Novel Regulator of Nox4 and Cytoskeletal Integrity in Vascular Smooth Muscle Cells

(2009) Alicia N. Lyle et al.   CIRCULATION RESEARCH

Oxidative Stress-Induced Necrotic Cell Death via Mitochondira-Dependent Burst of Reactive Oxygen Species

(2009) Kyungsun Choi et al.   CURRENT NEUROVASCULAR RESEARCH

The impact of ischaemia–reperfusion on the blood vessel

(2009) Maximilien J Gourdin et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

To prevent, protect and save the ischemic heart: antioxidants revisited

(2009) Ioanna Andreadou et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Inhibition of NADPH Oxidase is Neuroprotective after Ischemia—Reperfusion

(2009) Hai Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Translating the oxidative stress hypothesis into the clinic: NOX versus NOS

(2009) Melanie E. Armitage et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Subcellular localization of Nox4 and regulation in diabetes

(2009) K. Block et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xanthine oxidoreductase in respiratory and cardiovascular disorders

(2008) Adel Boueiz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

NADPH Oxidase in Bone Marrow–Derived Cells Mediates Pulmonary Ischemia-Reperfusion Injury

(2008) Zequan Yang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

NADPH Oxidase-Dependent Signaling in Endothelial Cells: Role in Physiology and Pathophysiology

(2008) Randall S. Frey et al.   ANTIOXIDANTS & REDOX SIGNALING

Nox4 Acts as a Switch Between Differentiation and Proliferation in Preadipocytes

(2008) Katrin Schröder et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effects of Vitamins C and E on the Outcome after Acute Myocardial Infarction in Diabetics: A Retrospective, Hypothesis-Generating Analysis from the MIVIT Study

(2008) Tomasz Jaxa-Chamiec et al.   CARDIOLOGY

Cardiac oxidative stress and remodeling following infarction: role of NADPH oxidase

(2008) Wenyuan Zhao et al.   CARDIOVASCULAR PATHOLOGY

Role of Nox2-Based NADPH Oxidase in Bone Marrow and Progenitor Cell Function Involved in Neovascularization Induced by Hindlimb Ischemia

(2008) Norifumi Urao et al.   CIRCULATION RESEARCH

Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells

(2008) Desmond B. Jay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Involvement of Nox2 NADPH Oxidase in Adverse Cardiac Remodeling After Myocardial Infarction

(2008) Yee H. Looi et al.   HYPERTENSION

Role of NADPH oxidase in H9c2 cardiac muscle cells exposed to simulated ischaemia-reperfusion

(2008) Elisabetta Borchi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Induction of HIF-1α expression by intermittent hypoxia: Involvement of NADPH oxidase, Ca2+signaling, prolyl hydroxylases, and mTOR

(2008) Guoxiang Yuan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Calcium-Dependent NOX5 Nicotinamide Adenine Dinucleotide Phosphate Oxidase Contributes to Vascular Oxidative Stress in Human Coronary Artery Disease

(2008) Tomasz J. Guzik et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitochondrial Pathophysiology, Reactive Oxygen Species, and Cardiovascular Diseases

(2008) Ling Gao et al.   VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies

(2008) Ulrich Förstermann   Nature clinical practice. Cardiovascular medicine

Ischemic Preconditioning: From Molecular Mechanisms to Therapeutic Opportunities

(2007) Hajime Otani   ANTIOXIDANTS & REDOX SIGNALING

Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant

(2007) Sabine Heumüller et al.   HYPERTENSION