Targeting microglia-mediated neurotoxicity: the potential of NOX2 inhibitors

Neuroinflammation in Alzheimer's Disease and Mild Cognitive Impairment: A Field in Its Infancy

(2017) Edith G. McGeer et al.   JOURNAL OF ALZHEIMERS DISEASE

Macrophage Antigen Complex-1 Mediates Reactive Microgliosis and Progressive Dopaminergic Neurodegeneration in the MPTP Model of Parkinson's Disease

(2014) X. Hu et al.   JOURNAL OF IMMUNOLOGY

Potent Anti-Inflammatory and Neuroprotective Effects of TGF- 1 Are Mediated through the Inhibition of ERK and p47phox-Ser345 Phosphorylation and Translocation in Microglia

(2014) L. Qian et al.   JOURNAL OF IMMUNOLOGY

NSAID use and risk of Parkinson disease: a population-based case-control study

(2011) C. Becker et al.   EUROPEAN JOURNAL OF NEUROLOGY

The promise of anti-inflammatory therapies for CNS injuries and diseases

(2011) Serge Rivest   Expert Review of Neurotherapeutics

NADPH-oxidase activation and cognition in Alzheimer disease progression

(2011) Mubeen A. Ansari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impaired CD200–CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: Roles of aging, superoxide, NADPH oxidase, and p38 MAPK

(2011) Xi-Jin Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Alsin and SOD1G93AProteins Regulate Endosomal Reactive Oxygen Species Production by Glial Cells and Proinflammatory Pathways Responsible for Neurotoxicity

(2011) Qiang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cannabinoid Receptor Type 1 Protects Nigrostriatal Dopaminergic Neurons against MPTP Neurotoxicity by Inhibiting Microglial Activation

(2011) Y. C. Chung et al.   JOURNAL OF IMMUNOLOGY

Enhanced neuroinflammation and pain hypersensitivity after peripheral nerve injury in rats expressing mutated superoxide dismutase 1

(2011) Julie V Berger et al.   Journal of Neuroinflammation

Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity

(2011) Dan Zhang et al.   Journal of Neuroinflammation

Amyloid  -Induced Impairments in Hippocampal Synaptic Plasticity Are Rescued by Decreasing Mitochondrial Superoxide

(2011) T. Ma et al.   JOURNAL OF NEUROSCIENCE

HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration

(2011) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Etiology and pathogenesis of Parkinson's disease

(2011) Anthony H. Schapira et al.   MOVEMENT DISORDERS

Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord

(2011) Olga V. Chechneva et al.   NEUROBIOLOGY OF DISEASE

NADPH oxidase is involved in post-ischemic brain inflammation

(2011) Hai Chen et al.   NEUROBIOLOGY OF DISEASE

Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation

(2011) Young C. Chung et al.   NEUROPHARMACOLOGY

Prospects of Statins in Parkinson Disease

(2011) Avik Roy et al.   NEUROSCIENTIST

Andrographolide Inhibits PI3K/AKT-Dependent NOX2 and iNOS Expression Protecting Mice against Hypoxia/Ischemia-Induced Oxidative Brain Injury

(2011) Chang-Ming Chern et al.   PLANTA MEDICA

Chronic Apocynin Treatment Attenuates Beta Amyloid Plaque Size and Microglial Number in hAPP(751)SL Mice

(2011) Melinda E. Lull et al.   PLoS One

Nox2 Oxidase Activity Accounts for the Oxidative Stress and Vasomotor Dysfunction in Mouse Cerebral Arteries following Ischemic Stroke

(2011) T. Michael De Silva et al.   PLoS One

Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

(2011) O. Pascual et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: Implication for antioxidative psychotropic actions via microglia

(2011) Takahiro A. Kato et al.   SCHIZOPHRENIA RESEARCH

Statins in Neurological Disorders: Mechanisms and Therapeutic Value

(2011) Allison B. Reiss et al.   TheScientificWorldJOURNAL

NOX2 Complex–Derived ROS as Immune Regulators

(2010) Outi Sareila et al.   ANTIOXIDANTS & REDOX SIGNALING

Effects of F/G-actin ratio and actin turn-over rate on NADPH oxidase activity in microglia

(2010) Izabela Rasmussen et al.   BMC IMMUNOLOGY

Reactive microgliosis: extracellular μ-calpain and microglia-mediated dopaminergic neurotoxicity

(2010) Shannon Levesque et al.   BRAIN

Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice

(2010) Shau-Kwaun Chen et al.   CELL

Acute NADPH oxidase activation potentiates cerebrovascular permeability response to bradykinin in ischemia–reperfusion

(2010) Abigail Woodfin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Paroxetine Prevents Loss of Nigrostriatal Dopaminergic Neurons by Inhibiting Brain Inflammation and Oxidative Stress in an Experimental Model of Parkinson's Disease

(2010) Y. C. Chung et al.   JOURNAL OF IMMUNOLOGY

mGluR1 antagonist decreased NADPH oxidase activity and superoxide production after transient focal cerebral ischemia

(2010) Kazutoshi Murotomi et al.   JOURNAL OF NEUROCHEMISTRY

Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury

(2010) Kenji Dohi et al.   Journal of Neuroinflammation

The NADPH Oxidase NOX2 Controls Glutamate Release: A Novel Mechanism Involved in Psychosis-Like Ketamine Responses

(2010) S. Sorce et al.   JOURNAL OF NEUROSCIENCE

Inhibition of I B Kinase-  Protects Dopamine Neurons Against Lipopolysaccharide-Induced Neurotoxicity

(2010) F. Zhang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inflammatory Neurodegeneration and Mechanisms of Microglial Killing of Neurons

(2010) Guy C. Brown et al.   MOLECULAR NEUROBIOLOGY

Resveratrol Protects Dopamine Neurons Against Lipopolysaccharide-Induced Neurotoxicity through Its Anti-Inflammatory Actions

(2010) F. Zhang et al.   MOLECULAR PHARMACOLOGY

Nox2 redox signaling maintains essential cell populations in the brain

(2010) Bryan C Dickinson et al.   Nature Chemical Biology

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease

(2010) Brandy L. Wilkinson et al.   NEUROBIOLOGY OF AGING

Verapamil protects dopaminergic neuron damage through a novel anti-inflammatory mechanism by inhibition of microglial activation

(2010) Yuxin Liu et al.   NEUROPHARMACOLOGY

Docosahexaenoic Acid Suppresses Neuroinflammatory Responses and Induces Heme Oxygenase-1 Expression in BV-2 Microglia: Implications of Antidepressant Effects for Omega-3 Fatty Acids

(2010) Dah-Yuu Lu et al.   NEUROPSYCHOPHARMACOLOGY

HIV-Tat elicits microglial glutamate release: Role of NAPDH oxidase and the cystine–glutamate antiporter

(2010) Sunita Gupta et al.   NEUROSCIENCE LETTERS

Role of microglia in neurotrauma

(2010) David J. Loane et al.   Neurotherapeutics

Microglial activation and chronic neurodegeneration

(2010) Melinda E. Lull et al.   Neurotherapeutics

Role of Rac1 GTPase in NADPH Oxidase Activation and Cognitive Impairment Following Cerebral Ischemia in the Rat

(2010) Limor Raz et al.   PLoS One

NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain

(2010) D. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changing Face of Microglia

(2010) M. B. Graeber   SCIENCE

Neuroprotective effects of hydrogen sulfide on Parkinson’s disease rat models

(2009) Li-Fang Hu et al.   AGING CELL

NOX Enzymes in the Central Nervous System: From Signaling to Disease

(2009) Silvia Sorce et al.   ANTIOXIDANTS & REDOX SIGNALING

Small-Molecule NOX Inhibitors: ROS-Generating NADPH Oxidases as Therapeutic Targets

(2009) Vincent Jaquet et al.   ANTIOXIDANTS & REDOX SIGNALING

Involvement of NOX2 in the Development of Behavioral and Pathologic Alterations in Isolated Rats

(2009) Stefania Schiavone et al.   BIOLOGICAL PSYCHIATRY

NSAID Use and the Risk of Parkinsonʼs Disease

(2009) Ali Samii et al.   DRUGS & AGING

Effects of CYP3A5, MDR1 and CACNA1C polymorphisms on the oral disposition and response of nimodipine in a Chinese cohort

(2009) Ying Zhao et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Activation of Metabotropic Glutamate Receptor 5 Modulates Microglial Reactivity and Neurotoxicity by Inhibiting NADPH Oxidase

(2009) David J. Loane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of NADPH Oxidase is Neuroprotective after Ischemia—Reperfusion

(2009) Hai Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

IL-13-Induced Oxidative Stress via Microglial NADPH Oxidase Contributes to Death of Hippocampal Neurons In Vivo

(2009) K. W. Park et al.   JOURNAL OF IMMUNOLOGY

Lipopolysaccharide-induced radical formation in the striatum is abolished in Nox2 gp91phox-deficient mice

(2009) Hans-Willi Clement et al.   JOURNAL OF NEURAL TRANSMISSION

Life and Death of Microglia

(2009) Wolfgang J. Streit et al.   Journal of Neuroimmune Pharmacology

Prothrombin kringle-2-induced oxidative stress contributes to the death of cortical neurons in vivo and in vitro: Role of microglial NADPH oxidase

(2009) So Y. Won et al.   JOURNAL OF NEUROIMMUNOLOGY

Simvastatin Inhibits the Activation of p21ras and Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson's Disease

(2009) A. Ghosh et al.   JOURNAL OF NEUROSCIENCE

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

Oral phycocyanobilin may diminish the pathogenicity of activated brain microglia in neurodegenerative disorders

(2009) Mark F. McCarty et al.   MEDICAL HYPOTHESES

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

(2009) Sonia Gandhi et al.   MOLECULAR CELL

Novel Neuroprotective Mechanisms of Memantine: Increase in Neurotrophic Factor Release from Astroglia and Anti-Inflammation by Preventing Microglial Activation

(2009) Hung-Ming Wu et al.   NEUROPSYCHOPHARMACOLOGY

Oxidative damage to neurons caused by the induction of microglial NADPH oxidase in encephalomyocarditis virus infection

(2009) Yasuhisa Ano et al.   NEUROSCIENCE LETTERS

Neuromelanin Activates Microglia and Induces Degeneration of Dopaminergic Neurons: Implications for Progression of Parkinson’s Disease

(2009) Wei Zhang et al.   NEUROTOXICITY RESEARCH

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

NADPH Oxidase Drives Cytokine and Neurotoxin Release from Microglia and Macrophages in Response to HIV-Tat

(2008) Jadwiga Turchan–Cholewo et al.   ANTIOXIDANTS & REDOX SIGNALING

Endosomal Nox2 Facilitates Redox-Dependent Induction of NF-κB by TNF-α

(2008) Qiang Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Compartmentalization of Redox Signaling Through NADPH Oxidase–Derived ROS

(2008) Masuko Ushio-Fukai   ANTIOXIDANTS & REDOX SIGNALING

Nox4 and Nox2 NADPH Oxidases Mediate Distinct Cellular Redox Signaling Responses to Agonist Stimulation

(2008) Narayana Anilkumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Formyl-methionyl-leucyl-phenylalanine–Induced Dopaminergic Neurotoxicity via Microglial Activation: A Mediator between Peripheral Infection and Neurodegeneration?

(2008) Xi Gao et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Activation of nicotinic acetylcholine receptor prevents the production of reactive oxygen species in fibrillar β amyloid peptide (1-42)-stimulated microglia

(2008) Ju Hyun Moon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation

(2008) Camelia A. Danilov et al.   GLIA

Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidases

(2008) Timothy J. Harrigan et al.   JOURNAL OF NEUROCHEMISTRY

Docosahexaenoic acid prevents lipopolysaccharide-induced cytokine production in microglial cells by inhibiting lipopolysaccharide receptor presentation but not its membrane subdomain localization

(2008) Véronique De Smedt-Peyrusse et al.   JOURNAL OF NEUROCHEMISTRY

Zinc Triggers Microglial Activation

(2008) T. M. Kauppinen et al.   JOURNAL OF NEUROSCIENCE

Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid-β1-42

(2008) Juefei Zhou et al.   JOURNAL OF PINEAL RESEARCH

Brain angiotensin enhances dopaminergic cell death via microglial activation and NADPH-derived ROS

(2008) J. Rodriguez-Pallares et al.   NEUROBIOLOGY OF DISEASE

Statin use and the risk of Parkinson disease

(2008) A. D. Wahner et al.   NEUROLOGY

Nimodipine protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation

(2008) Yachen Li et al.   NEUROPHARMACOLOGY

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

(2008) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant

(2007) Sabine Heumüller et al.   HYPERTENSION

Lipopolysaccharide induces hypoxia-inducible factor-1 alpha mRNA expression and activation via NADPH oxidase and Sp1-dependent pathway in BV2 murine microglial cells

(2007) Young Taek Oh et al.   NEUROSCIENCE LETTERS