New Generation of Biocatalysts for Organic Synthesis

Artificial Multi-Enzyme Networks for the Asymmetric Amination ofsec-Alcohols

(2013) Katharina Tauber et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Mechanisms and Biocatalytic Applications of Aspartate and Methylaspartate Ammonia Lyases

(2012) Marianne de Villiers et al.   ACS Chemical Biology

A Three-Enzyme System Involving an Ene-Reductase for Generating Valuable Chiral Building Blocks

(2012) David Mangan et al.   ADVANCED SYNTHESIS & CATALYSIS

Ene Reductase-Catalysed Synthesis of (R)-Profen Derivatives

(2012) Jörg Pietruszka et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Bio-amination of Ketones in Organic Solvents

(2012) Francesco G. Mutti et al.   ADVANCED SYNTHESIS & CATALYSIS

Redox Self-Sufficient Biocatalyst Network for the Amination of Primary Alcohols

(2012) Johann H. Sattler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of an Amine Dehydrogenase for Synthesis of Chiral Amines

(2012) Michael J. Abrahamson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regio- and Stereoselective Monoamination of Diketones without Protecting Groups

(2012) Robert C. Simon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Features and technical applications of ω-transaminases

(2012) M. Shaheer Malik et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Unusual CC Bond Isomerization of an α,β-Unsaturated γ-Butyrolactone Catalysed by Flavoproteins from the Old Yellow Enzyme Family

(2012) Katharina Durchschein et al.   CHEMBIOCHEM

A biocatalytic redox isomerisation

(2012) Serena Gargiulo et al.   CHEMICAL COMMUNICATIONS

An efficient single-enzymatic cascade for asymmetric synthesis of chiral amines catalyzed by ω-transaminase

(2012) Bo Wang et al.   CHEMICAL COMMUNICATIONS

Epoxide Hydrolases and their Application in Organic Synthesis

(2012) Michael Kotik et al.   CURRENT ORGANIC CHEMISTRY

Asymmetric bioreduction of activated alkenes to industrially relevant optically active compounds

(2012) Christoph K. Winkler et al.   JOURNAL OF BIOTECHNOLOGY

Engineering the third wave of biocatalysis

(2012) U. T. Bornscheuer et al.   NATURE

Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids

(2012) Hans Raj et al.   Nature Chemistry

Mimicking Nature: Synthetic Nicotinamide Cofactors for C═C Bioreduction Using Enoate Reductases

(2012) Caroline E. Paul et al.   ORGANIC LETTERS

Synthesis of optically active dihydrocarveol via a stepwise or one-pot enzymatic reduction of (R)- and (S)-carvone

(2012) Xi Chen et al.   TETRAHEDRON-ASYMMETRY

ω-Transaminases for the Production of Optically Pure Amines and Unnatural Amino Acids

(2012) Sam Mathew et al.   ACS Catalysis

Reductive dehalogenation of β-haloacrylic ester derivatives mediated by ene-reductases

(2012) Gábor Tasnádi et al.   Catalysis Science & Technology

Transaminases for the synthesis of enantiopure beta-amino acids

(2012) Jens Rudat et al.   AMB Express

Stereo-Controlled Asymmetric Bioreduction of α,β-Dehydroamino Acid Derivatives

(2011) Clemens Stueckler et al.   ADVANCED SYNTHESIS & CATALYSIS

Old Yellow Enzyme-Catalyzed Dehydrogenation of Saturated Ketones

(2011) Matthias Schittmayer et al.   ADVANCED SYNTHESIS & CATALYSIS

Mechanism-Inspired Engineering of Phenylalanine Aminomutase for Enhanced β-Regioselective Asymmetric Amination of Cinnamates

(2011) Bian Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One-Pot Synthesis of α-Amino Acids from Imines through CO2 Incorporation: An Alternative Method for Strecker Synthesis

(2011) Tsuyoshi Mita et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sitagliptin Manufacture: A Compelling Tale of Green Chemistry, Process Intensification, and Industrial Asymmetric Catalysis

(2011) Aman A. Desai   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

l-Aspartate dehydrogenase: features and applications

(2011) Yinxia Li et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Biocatalytic synthesis of chiralN-(2-hydroxyalkyl)-acrylamides

(2011) Leandro N. Monsalve et al.   BIOCATALYSIS AND BIOTRANSFORMATION

Mechanistic, Mutational, and Structural Evaluation of aTaxusPhenylalanine Aminomutase

(2011) Lei Feng et al.   BIOCHEMISTRY

QM/MM study of the mechanism of enzymatic limonene 1,2-epoxide hydrolysis

(2011) Q.Q. Hou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A highly efficient ADH-coupled NADH-recycling system for the asymmetric bioreduction of carbon-carbon double bonds using enoate reductases

(2011) Katharina Tauber et al.   BIOTECHNOLOGY AND BIOENGINEERING

Asymmetric synthesis of (R)-3-fluoroalanine from 3-fluoropyruvate using omega-transaminase

(2011) Han-Seop Bea et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Combination of CC Bond Formation by Wittig Reaction and Enzymatic CC Bond Reduction in a One-Pot Process in Water

(2011) Marina Kraußer et al.   ChemCatChem

Asymmetric Synthesis of (S)-2-Indolinecarboxylic Acid by Combining Biocatalysis and Homogeneous Catalysis

(2011) Ben de Lange et al.   ChemCatChem

Application of Designed Enzymes in Organic Synthesis

(2011) Gernot A. Strohmeier et al.   CHEMICAL REVIEWS

Enantioenriched Compounds via Enzyme-Catalyzed Redox Reactions

(2011) Mélanie Hall et al.   CHEMICAL REVIEWS

C−C Bond-Forming Lyases in Organic Synthesis

(2011) Margarita Brovetto et al.   CHEMICAL REVIEWS

Hydrolases in the Stereoselective Synthesis ofN-Heterocyclic Amines and Amino Acid Derivatives

(2011) Eduardo Busto et al.   CHEMICAL REVIEWS

Baeyer−Villiger Monooxygenases: More Than Just Green Chemistry

(2011) Hannes Leisch et al.   CHEMICAL REVIEWS

Redox Reactions Catalyzed by Isolated Enzymes

(2011) Daniela Monti et al.   CHEMICAL REVIEWS

Enantioselective Oxidation of C–O and C–N Bonds Using Oxidases

(2011) Nicholas J. Turner   CHEMICAL REVIEWS

Novel carbon–carbon bond formations for biocatalysis

(2011) Verena Resch et al.   CURRENT OPINION IN BIOTECHNOLOGY

Stereochemistry and Mechanism of a Microbial Phenylalanine Aminomutase

(2011) Nishanka Dilini Ratnayake et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reductive biotransformation of nitroalkenes via nitroso-intermediates to oxazetes catalyzed by xenobiotic reductase A (XenA)

(2011) Katharina Durchschein et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enoate Reductase-Mediated Preparation of Methyl (S)-2-Bromobutanoate, a Useful Key Intermediate for the Synthesis of Chiral Active Pharmaceutical Ingredients

(2011) Elisabetta Brenna et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Recent developments in the asymmetric hydrolytic ring opening of epoxides catalysed by microbial epoxide hydrolase

(2011) Neeraj Bala et al.   TETRAHEDRON-ASYMMETRY

Efficient Tandem Biocatalytic Process for the Kinetic Resolution of Aromatic β-Amino Acids

(2010) Bian Wu et al.   ADVANCED SYNTHESIS & CATALYSIS

Combining Designer Cells and Click Chemistry for a One-Pot Four-Step Preparation of Enantiopure β-Hydroxytriazoles

(2010) Wiktor Szymanski et al.   ADVANCED SYNTHESIS & CATALYSIS

One-Pot Conversion of L-Threonine into L-Homoalanine: Biocatalytic Production of an Unnatural Amino Acid from a Natural One

(2010) Eulsoo Park et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Biocatalytic Oxidative Desymmetrization of Substituted Pyrrolidines

(2010) Valentin Köhler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric reduction of activated alkenes using an enoate reductase from Gluconobacter oxydans

(2010) Nina Richter et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Rational Design of Pseudozyma antarctica Lipase B Yielding a General Esterification Catalyst

(2010) Danni Liu et al.   CHEMBIOCHEM

Creating a Biocatalyst for the Production of an Optically Pure Sterically Hindered Amine

(2010) Francesco G. Mutti et al.   ChemCatChem

Directed Evolution of Enantioconvergency: The Case of an Epoxide Hydrolase-Catalyzed Reaction of a Racemic Epoxide

(2010) Huabao Zheng et al.   ChemCatChem

Enantioselective Organocatalytic Strecker Reactions in the Synthesis of α-Amino Acids

(2010) Jürgen Martens   ChemCatChem

Biocatalytic Reductions and Chemical Versatility of the Old Yellow Enzyme Family of Flavoprotein Oxidoreductases

(2010) Helen S. Toogood et al.   ChemCatChem

Towards preparative-scale, biocatalytic alkene reductions

(2010) Despina J. Bougioukou et al.   CHEMICAL COMMUNICATIONS

Chemoenzymatic asymmetric total synthesis of (S)-Rivastigmine using ω-transaminases

(2010) Michael Fuchs et al.   CHEMICAL COMMUNICATIONS

One pot ‘click’ reactions: tandem enantioselective biocatalytic epoxide ring opening and [3+2] azide alkyne cycloaddition

(2010) Lachlan S. Campbell-Verduyn et al.   CHEMICAL COMMUNICATIONS

Hydrolases: catalytically promiscuous enzymes for non-conventional reactions in organic synthesis

(2010) Eduardo Busto et al.   CHEMICAL SOCIETY REVIEWS

Deracemisation methods

(2010) Nicholas J Turner   CURRENT OPINION IN CHEMICAL BIOLOGY

Recent biocatalytic oxidation–reduction cascades

(2010) Joerg H Schrittwieser et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Recent progress in industrial biocatalysis

(2010) Bettina M Nestl et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Ammonia lyases and aminomutases as biocatalysts for the synthesis of α-amino and β-amino acids

(2010) Nicholas J Turner   CURRENT OPINION IN CHEMICAL BIOLOGY

Bioreduction of α-methylcinnamaldehyde derivatives: chemo-enzymatic asymmetric synthesis of Lilial™ and Helional™

(2010) Clemens Stueckler et al.   DALTON TRANSACTIONS

Asymmetric Synthesis of O-Protected Acyloins Using Enoate Reductases: Stereochemical Control through Protecting Group Modification

(2010) Christoph K. Winkler et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Trichlorosilane-Mediated Stereoselective Reduction of C=N Bonds

(2010) Stefania Guizzetti et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The flavoprotein-catalyzed reduction of aliphatic nitro-compounds represents a biocatalytic equivalent to the Nef-reaction

(2010) Katharina Durchschein et al.   GREEN CHEMISTRY

Access to enantiopure aromatic epoxides and diols using epoxide hydrolases derived from total biofilter DNA

(2010) Michael Kotik et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Manipulating the Stereoselectivity of Limonene Epoxide Hydrolase by Directed Evolution Based on Iterative Saturation Mutagenesis

(2010) Huabao Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rational assignment of key motifs for function guides in silico enzyme identification

(2010) Matthias Höhne et al.   Nature Chemical Biology

ω-Transaminases as efficient biocatalysts to obtain novel chiral selenium-amine ligands for Pd-catalysis

(2010) Leandro H. Andrade et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Reengineering Enzymes

(2010) S. Lutz   SCIENCE

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

(2010) J. B. Siegel et al.   SCIENCE

ω-Transaminases for the synthesis of non-racemic α-chiral primary amines

(2010) Dominik Koszelewski et al.   TRENDS IN BIOTECHNOLOGY

Directed Evolution of an Enantioselective Enoate-Reductase: Testing the Utility of Iterative Saturation Mutagenesis

(2009) Despina J. Bougioukou et al.   ADVANCED SYNTHESIS & CATALYSIS

A Single Residue Influences the Reaction Mechanism of Ammonia Lyases and Mutases

(2009) Sebastian Bartsch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure–function relationships of epoxide hydrolases and their potential use in biocatalysis

(2009) Mikael Widersten et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Biocatalytic asymmetric amination of carbonyl functional groups - a synthetic biology approach to organic chemistry

(2009) Dunming Zhu et al.   Biotechnology Journal

Alteration of the Diastereoselectivity of 3-Methylaspartate Ammonia Lyase by Using Structure-Based Mutagenesis

(2009) Hans Raj et al.   CHEMBIOCHEM

Enzymatic Synthesis of Enantiopure α- and β-Amino Acids by Phenylalanine Aminomutase-Catalysed Amination of Cinnamic Acid Derivatives

(2009) Bian Wu et al.   CHEMBIOCHEM

Biocatalytic Routes to Optically Active Amines

(2009) Matthias Höhne et al.   ChemCatChem

Synthesis of Optically Active Amines Employing Recombinant ω-Transaminases inE. coliCells

(2009) Dominik Koszelewski et al.   ChemCatChem

Efficient kinetic resolution of racemic amines using a transaminase in combination with an amino acid oxidase

(2009) Matthew D. Truppo et al.   CHEMICAL COMMUNICATIONS

Enantiomerically pure β-phenylalanine analogues from α–β-phenylalanine mixtures in a single reactive extraction step

(2009) Bastiaan J. V. Verkuijl et al.   CHEMICAL COMMUNICATIONS

Directed evolution: new parts and optimized function

(2009) Michael J Dougherty et al.   CURRENT OPINION IN BIOTECHNOLOGY

Deracemisation of α-Chiral Primary Amines by a One-Pot, Two-Step Cascade Reaction Catalysed by ω-Transaminases

(2009) Dominik Koszelewski et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A green-by-design biocatalytic process for atorvastatin intermediate

(2009) Steven K. Ma et al.   GREEN CHEMISTRY

Synthesis of 4-phenylpyrrolidin-2-one via dynamic kinetic resolution catalyzed by ω-transaminases

(2009) Dominik Koszelewski et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Increased activity of enzymatic transacylation of acrylates through rational design of lipases

(2009) Per-Olof Syrén et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Enhanced Conversion of Racemic α-Arylalanines to (R)-β-Arylalanines by Coupled Racemase/Aminomutase Catalysis

(2009) Brad M. Cox et al.   JOURNAL OF ORGANIC CHEMISTRY

Chiral Separation of Underivatized Amino Acids by Reactive Extraction with Palladium−BINAP Complexes

(2009) Bastiaan J. V. Verkuijl et al.   JOURNAL OF ORGANIC CHEMISTRY

Scaleable catalytic asymmetric Strecker syntheses of unnatural α-amino acids

(2009) Stephan J. Zuend et al.   NATURE

Exploring protein fitness landscapes by directed evolution

(2009) Philip A. Romero et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A short, chemoenzymatic route to chiral β-aryl-γ-amino acids using reductases from anaerobic bacteria

(2009) Anna Fryszkowska et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Deracemization of Mexiletine Biocatalyzed by ω-Transaminases

(2009) Dominik Koszelewski et al.   ORGANIC LETTERS

A Multidisciplinary Approach Toward the Rapid and Preparative-Scale Biocatalytic Synthesis of Chiral Amino Alcohols: A Concise Transketolase-/ω-Transaminase-Mediated Synthesis of (2S,3S)-2-Aminopentane-1,3-diol

(2009) Mark E. B. Smith et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

In the light of directed evolution: Pathways of adaptive protein evolution

(2009) J. D. Bloom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nicotinamide-independent asymmetric bioreduction of CC-bonds via disproportionation of enones catalyzed by enoate reductases

(2009) Clemens Stueckler et al.   TETRAHEDRON

Formal Asymmetric Biocatalytic Reductive Amination

(2008) Dominik Koszelewski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Vinyl ketone reduction by three distinct Gluconobacter oxydans 621H enzymes

(2008) Paul Schweiger et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The Occurrence of a Novel NADH Dehydrogenase, Distinct from the Old Yellow Enzyme, inGluconobacterStrains

(2008) Emiko SHINAGAWA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Asymmetric Synthesis of (S)-α-Methylbenzylamine by RecombinantEscherichia coliCo-Expressing Omega-Transaminase and Acetolactate Synthase

(2008) Hyungdon YUN et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Efficient Asymmetric Synthesis of Chiral Amines by Combining Transaminase and Pyruvate Decarboxylase

(2008) Matthias Höhne et al.   CHEMBIOCHEM

Catalytic Promiscuity of Halohydrin Dehalogenase and its Application in Enantioselective Epoxide Ring Opening

(2008) Ghannia Hasnaoui-Dijoux et al.   CHEMBIOCHEM

Addressing the Numbers Problem in Directed Evolution

(2008) Manfred T. Reetz et al.   CHEMBIOCHEM

Biocatalytic Enantioselective Synthesis ofN-Substituted Aspartic Acids by Aspartate Ammonia Lyase

(2008) Barbara Weiner et al.   CHEMISTRY-A EUROPEAN JOURNAL

Metal-Catalyzed One-Step Synthesis: Towards Direct Alternatives to Multistep Heterocycle and Amino Acid Derivative Formation

(2008) Bruce A. Arndtsen   CHEMISTRY-A EUROPEAN JOURNAL

Dynamic Kinetic Resolution of Racemic β-Haloalcohols: Direct Access to Enantioenriched Epoxides

(2008) Robert M. Haak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kemp elimination catalysts by computational enzyme design

(2008) Daniela Röthlisberger et al.   NATURE

De Novo Computational Design of Retro-Aldol Enzymes

(2008) L. Jiang et al.   SCIENCE