Journal
TETRAHEDRON-ASYMMETRY
Volume 23, Issue 10, Pages 734-738Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2012.05.019
Keywords
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Funding
- National Basic Research Program of China (973 Program) [2011CB710801]
- Chinese Academy of Sciences
- Tianjin Municipal Science & Technology Commission [10 ZCZDSY06600]
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A recombinant enoate reductase LacER from Lactobacillus casei catalyzed the reduction of (R)-carvone and (S)-carvone to give (2R,5R)-dihydrocarvone and (2R,5S)-dihydrocarvone with 99% and 86% de, respectively, which were further reduced to dihydrocarveols by a carbonyl reductase from Sporobolomyces salmonicolor SSCR or Candida magnolia CMCR. For (R)-carvone, (1S,2R,5R)-dihydrocarveol was produced as the sole product with >99% conversion, while (15,2R,5S)-dihydrocarveol was obtained as the major product, but with a lower de when (S)-carvone was used as the substrate. The one-pot reduction was performed at a 0.1 M substrate concentration, indicating that it might provide an effective synthetic route to this type of chiral compound. (C) 2012 Elsevier Ltd. All rights reserved.
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