Post-ischaemic silencing of p66Shcreduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke

Cardiovascular disease in Europe 2014: epidemiological update

(2014) Melanie Nichols et al.   EUROPEAN HEART JOURNAL

Adaptor Protein p66 Shc Mediates Hypertension-Associated, Cyclic Stretch–Dependent, Endothelial Damage

(2014) Remo D. Spescha et al.   HYPERTENSION

Mitochondria-Targeted Antioxidant Peptide SS31 Prevents Hypoxia/Reoxygenation-Induced Apoptosis by Down-Regulating p66Shc in Renal Tubular Epithelial Cells

(2013) Wen-Yu Zhao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Angiopoietin-like 4 and ischaemic stroke: a promising start

(2013) R. D. Spescha et al.   EUROPEAN HEART JOURNAL

Protective effects of angiopoietin-like 4 on cerebrovascular and functional damages in ischaemic stroke

(2013) Claire Bouleti et al.   EUROPEAN HEART JOURNAL

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Moderate Hypoxia Followed by Reoxygenation Results in Blood-Brain Barrier Breakdown via Oxidative Stress-Dependent Tight-Junction Protein Disruption

(2013) Christoph M. Zehendner et al.   PLoS One

Nogo-A is a negative regulator of CNS angiogenesis

(2013) T. Walchli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene Silencing of the Mitochondrial Adaptor p66 Shc Suppresses Vascular Hyperglycemic Memory in Diabetes

(2012) Francesco Paneni et al.   CIRCULATION RESEARCH

Deletion of the ageing gene p66Shc reduces early stroke size following ischaemia/reperfusion brain injury

(2012) Remo D. Spescha et al.   EUROPEAN HEART JOURNAL

Oxidized Low-Density Lipoprotein Activates p66 Shc via Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1, Protein Kinase C-β, and c-Jun N-Terminal Kinase Kinase in Human Endothelial Cells

(2011) Yi Shi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Expression of the aging gene p66Shc is increased in peripheral blood monocytes of patients with acute coronary syndrome but not with stable coronary artery disease

(2011) Fabian C. Franzeck et al.   ATHEROSCLEROSIS

Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease

(2011) Christian Besler et al.   JOURNAL OF CLINICAL INVESTIGATION

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

(2011) Grant R. Drummond et al.   NATURE REVIEWS DRUG DISCOVERY

Role of blood cells in ischaemia-reperfusion induced endothelial barrier failure

(2010) S. F. Rodrigues et al.   CARDIOVASCULAR RESEARCH

Anti-Aging Medicine: Molecular Basis for Endothelial Cell-Targeted Strategies – A Mini-Review

(2010) Giovanni G. Camici et al.   GERONTOLOGY

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Decreased Superoxide Production in Macrophages of Long-lived p66Shc Knock-out Mice

(2009) Alexey A. Tomilov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p66Shc protein, oxidative stress, and cardiovascular complications of diabetes: the missing link

(2009) Pietro Francia et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations

(2009) Marc Fisher et al.   STROKE

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke

(2008) Enming J Su et al.   NATURE MEDICINE

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Early Disruption of the Blood–Brain Barrier After Thrombolytic Therapy Predicts Hemorrhage in Patients With Acute Stroke

(2008) Andreas Kastrup et al.   STROKE

Final Common Molecular Pathways of Aging and Cardiovascular Disease

(2007) Francesco Cosentino et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant

(2007) Sabine Heumüller et al.   HYPERTENSION