Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage

Somatic mitochondrial DNA mutations in early parkinson and incidental lewy body disease

(2012) Michael T. Lin et al.   ANNALS OF NEUROLOGY

The free-radical theory of ageing - older, wiser and still alive

(2012) Thomas B. L. Kirkwood et al.   BIOESSAYS

DNA Replication and Strand Asymmetry in Prokaryotic and Mitochondrial Genomes

(2012) Xuhua Xia   CURRENT GENOMICS

Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction

(2012) Amy M. Furda et al.   DNA REPAIR

Detection of ultra-rare mutations by next-generation sequencing

(2012) M. W. Schmitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations

(2012) Laura C. Greaves et al.   PLoS Genetics

Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis

(2011) Ruth Halsne et al.   DNA REPAIR

Differences in the accumulation of mitochondrial defects with age in mice and humans

(2011) Laura C. Greaves et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Somatic mutations in aging, cancer and neurodegeneration

(2011) Scott R. Kennedy et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins

(2011) Adam Ameur et al.   PLoS Genetics

Human aging and somatic point mutations in mtDNA: a comparative study of generational differences (grandparents and grandchildren)

(2010) Anderson Nonato do Rosário Marinho et al.   GENETICS AND MOLECULAR BIOLOGY

Heteroplasmic mitochondrial DNA mutations in normal and tumour cells

(2010) Yiping He et al.   NATURE

Mutational Heterogeneity in Human Cancers: Origin and Consequences

(2009) Jesse J. Salk et al.   Annual Review of Pathology-Mechanisms of Disease

Automated inference of molecular mechanisms of disease from amino acid substitutions

(2009) B. Li et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Random Point Mutations with Major Effects on Protein-Coding Genes Are the Driving Force behind Premature Aging in mtDNA Mutator Mice

(2009) Daniel Edgar et al.   Cell Metabolism

Evaluation of next generation sequencing platforms for population targeted sequencing studies

(2009) Olivier Harismendy et al.   GENOME BIOLOGY

Quantification of random mutations in the mitochondrial genome

(2008) Marc Vermulst et al.   METHODS