Nuclear and Mitochondrial DNA Repair in Selected Eukaryotic Aging Model Systems

The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging

(2016) Daniel Edgar et al.   Aging-US

Cockayne Syndrome B protein antagonizes OGG1 in modulating CAG repeat length in vivo

(2016) Irina V. Kovtun et al.   Aging-US

The oxidative DNA lesions 8,5′-cyclopurines accumulate with aging in a tissue-specific manner

(2012) Jin Wang et al.   AGING CELL

Role of Forkhead Transcription Factors in Diabetes-Induced Oxidative Stress

(2012) Bhaskar Ponugoti et al.   Experimental Diabetes Research

Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: Cross sectional and longitudinal studies

(2012) Mette Soerensen et al.   EXPERIMENTAL GERONTOLOGY

Age-dependent increases in the oxidative damage of DNA, RNA, and their metabolites in normal and senescence-accelerated mice analyzed by LC–MS/MS: Urinary 8-oxoguanosine as a novel biomarker of aging

(2012) Wei Gan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy

(2012) Morten Scheibye-Knudsen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oxidative damage to DNA and single strand break repair capacity: Relationship to other measures of oxidative stress in a population cohort

(2012) Andrzej R. Trzeciak et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The continuing value of twin studies in the omics era

(2012) Jenny van Dongen et al.   NATURE REVIEWS GENETICS

Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis

(2011) Mette Soerensen et al.   AGING CELL

Multiple DNA damage recognition factors involved in mammalian nucleotide excision repair

(2011) K. Sugasawa   BIOCHEMISTRY-MOSCOW

Premature aging and cancer in nucleotide excision repair-disorders

(2011) K. Diderich et al.   DNA REPAIR

Physiological consequences of defects in ERCC1–XPF DNA repair endonuclease

(2011) Siobhán Q. Gregg et al.   DNA REPAIR

Study of DNA damage via the comet assay and base excision repair activities in rat brain neurons and astrocytes during aging

(2011) Umakanta Swain et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The excitatory neurotransmitter glutamate stimulates DNA repair to increase neuronal resiliency

(2011) Jenq-Lin Yang et al.   MECHANISMS OF AGEING AND DEVELOPMENT

DNA repair deficiency in neurodegeneration

(2011) Dennis Kjølhede Jeppesen et al.   PROGRESS IN NEUROBIOLOGY

The Role of Oxidative Stress in the Aging Process

(2011) Barbara F. Oliveira et al.   TheScientificWorldJOURNAL

Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data

(2010) Mette Soerensen et al.   AGING CELL

Roles of Werner syndrome protein in protection of genome integrity

(2010) Marie L. Rossi et al.   DNA REPAIR

DNA repair in mammalian mitochondria: Much more than we thought?

(2010) Pingfang Liu et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Mitochondrial DNA repair and association with aging – An update

(2010) Ricardo Gredilla et al.   EXPERIMENTAL GERONTOLOGY

Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane

(2010) Maria D. Aamann et al.   FASEB JOURNAL

Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury

(2010) Bartosz Szczesny et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Common variants near TERC are associated with mean telomere length

(2010) Veryan Codd et al.   NATURE GENETICS

Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease

(2010) Ricardo Gredilla et al.   NEUROBIOLOGY OF AGING

Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology

(2010) D. Levy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On Mitochondria, Mutations, and Methodology

(2009) Marc Vermulst et al.   Cell Metabolism

Purification and characterization of Caenorhabditis elegans NTH, a homolog of human endonuclease III: Essential role of N-terminal region

(2009) Hironobu Morinaga et al.   DNA REPAIR

Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA

(2009) Michael K. Chan et al.   DNA REPAIR

Novel DNA mismatch-repair activity involving YB-1 in human mitochondria

(2009) Nadja C. de Souza-Pinto et al.   DNA REPAIR

DNA-PKcs and ATM co-regulate DNA double-strand break repair

(2009) Meena Shrivastav et al.   DNA REPAIR

Accumulation of mitochondrial DNA damage and bioenergetic dysfunction in CSB defective cells

(2009) Pia Ø. Osenbroch et al.   FEBS Journal

A potential impact of DNA repair on ageing and lifespan in the ageing model organism Podospora anserina: Decrease in mitochondrial DNA repair activity during ageing

(2009) Mette Soerensen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians

(2009) Almut Nebel et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians

(2009) G. Atzmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stoichiometry of Base Excision Repair Proteins Correlates with Increased Somatic CAG Instability in Striatum over Cerebellum in Huntington's Disease Transgenic Mice

(2009) Agathi-Vassiliki Goula et al.   PLoS Genetics

Telomere Length and Mortality: A Study of Leukocytes in Elderly Danish Twins

(2008) M. Kimura et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging

(2008) Dharmendra Kumar Singh et al.   BIOGERONTOLOGY

Somatic mtDNA mutations and aging – Facts and fancies

(2008) Alexandra Kukat et al.   EXPERIMENTAL GERONTOLOGY

Age, sex, and race influence single-strand break repair capacity in a human population

(2008) Andrzej R. Trzeciak et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons

(2008) Hirokazu Fukui et al.   HUMAN MOLECULAR GENETICS

The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging

(2008) Tinna Stevnsner et al.   MECHANISMS OF AGEING AND DEVELOPMENT

DNA2 Resolves Expanding Flap in Mitochondrial Base Excision Repair

(2008) William C. Copeland et al.   MOLECULAR CELL

Human DNA2 Is a Mitochondrial Nuclease/Helicase for Efficient Processing of DNA Replication and Repair Intermediates

(2008) Li Zheng et al.   MOLECULAR CELL

Podospora anserina: a model organism to study mechanisms of healthy ageing

(2008) Christian Q. Scheckhuber et al.   MOLECULAR GENETICS AND GENOMICS

An optimized method for measurement of gamma-H2AX in blood mononuclear and cultured cells

(2008) Aida Muslimovic et al.   Nature Protocols

DNA base excision repair activities in mouse models of Alzheimer's disease

(2008) Lior Weissman et al.   NEUROBIOLOGY OF AGING

Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions

(2008) Ricardo Gredilla et al.   NEUROBIOLOGY OF AGING

Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes

(2008) Ella Dragileva et al.   NEUROBIOLOGY OF DISEASE

Longevity and resistance to stress correlate with DNA repair capacity in Caenorhabditis elegans

(2008) Moonjung Hyun et al.   NUCLEIC ACIDS RESEARCH

FOXO3A genotype is strongly associated with human longevity

(2008) B. J. Willcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations

(2007) Andriy Marusyk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Bleomycin-induced double-strand breaks in mitochondrial DNA of Drosophila cells are repaired

(2007) Frederic Morel et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS