Integrated Redox Sensor and Effector Functions for Tetrahydrobiopterin- and Glutathionylation-dependent Endothelial Nitric-oxide Synthase Uncoupling

Systemic and Vascular Oxidation Limits the Efficacy of Oral Tetrahydrobiopterin Treatment in Patients With Coronary Artery Disease

(2012) Colin Cunnington et al.   CIRCULATION

S-glutathionylation uncouples eNOS and regulates its cellular and vascular function

(2010) Chun-An Chen et al.   NATURE

Thiol-metabolizing proteins and endothelial redox state: differential modulation of eNOS and biopterin pathways

(2009) Toru Sugiyama et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Critical Role for Tetrahydrobiopterin Recycling by Dihydrofolate Reductase in Regulation of Endothelial Nitric-oxide Synthase Coupling

(2009) Mark J. Crabtree et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein S-glutathionylation: a regulatory device from bacteria to humans

(2009) Isabella Dalle-Donne et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS

(2008) Mark J. Crabtree et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status

(2008) Mark J. Crabtree et al.   JOURNAL OF BIOLOGICAL CHEMISTRY