Friend or foe: the role of microRNA in chemotherapy resistance

Stress Response of Glioblastoma Cells Mediated by miR-17-5p Targeting PTEN and the Passenger Strand miR-17-3p Targeting MDM2

(2015) Haoran Li et al.   Oncotarget

Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis, Chemosensitivity and Radiosensitivity

(2015) Swapna Asuthkar et al.   Oncotarget

MicroRNA miR-98 inhibits tumor angiogenesis and invasion by targeting activin receptor-like kinase-4 and matrix metalloproteinase-11

(2015) Vinayakumar Siragam et al.   Oncotarget

miR-137 restoration sensitizes multidrug-resistant MCF-7/ADM cells to anticancer agents by targeting YB-1

(2012) X. Zhu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

miR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A

(2012) X. Zhu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

MicroRNAs: novel factors in clinical diagnosis and prognosis for nasopharyngeal carcinoma

(2012) Shu Yang et al.   ACTA PHARMACOLOGICA SINICA

A novel tumor suppressor miRNA miR-520e contributes to suppression of hepatoma

(2012) Bo-an Li   ACTA PHARMACOLOGICA SINICA

Increased Expression of P-Glycoprotein and Doxorubicin Chemoresistance of Metastatic Breast Cancer Is Regulated by miR-298

(2012) Lili Bao et al.   AMERICAN JOURNAL OF PATHOLOGY

MicroRNA-214 Regulates the Acquired Resistance to Gefitinib via the PTEN/AKT Pathway in EGFR-mutant Cell Lines

(2012) Yong-Sheng Wang et al.   Asian Pacific Journal of Cancer Prevention

Misprocessing and functional arrest of microRNAs bymiR-Pirate: roles ofmiR-378andmiR-17

(2012) Zhaoqun Deng et al.   BIOCHEMICAL JOURNAL

Beyond KRAS mutation status: influence of KRAScopy number status and microRNAs on clinical outcome to cetuximab in metastatic colorectal cancer patients

(2012) Leonie JM Mekenkamp et al.   BMC CANCER

MiR-155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of Apaf-1 expression

(2012) Y-S Zang et al.   CANCER GENE THERAPY

MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN

(2012) Li-Yi Zhang et al.   CARCINOGENESIS

MicroRNAs in Stress Signaling and Human Disease

(2012) Joshua T. Mendell et al.   CELL

An anti-let-7 sponge decoys and decays endogenous let-7 functions

(2012) Xiangling Yang et al.   CELL CYCLE

MiR-93 enhances angiogenesis and metastasis by targeting LATS2

(2012) Ling Fang et al.   CELL CYCLE

Versican 3′-untranslated region (3′-UTR) functions as a ceRNA in inducing the development of hepatocellular carcinoma by regulating miRNA activity

(2012) Ling Fang et al.   FASEB JOURNAL

The non-coding 3' UTR of CD44 induces metastasis by regulating extracellular matrix functions

(2012) Z. J. Rutnam et al.   JOURNAL OF CELL SCIENCE

MicroRNA-378a-5p promotes trophoblast cell survival, migration and invasion by targeting Nodal

(2012) Linlin Luo et al.   JOURNAL OF CELL SCIENCE

miR-221 and miR-222 promote Schwann cell proliferation and migration by targeting LASS2 after sciatic nerve injury

(2012) B. Yu et al.   JOURNAL OF CELL SCIENCE

miRNAs regulate expression and function of extracellular matrix molecules

(2012) Zina Jeyapalan Rutnam et al.   MATRIX BIOLOGY

Lentiviral Transgenic MicroRNA-Based shRNA Suppressed Mouse Cytochromosome P450 3A (CYP3A) Expression in a Dose-Dependent and Inheritable Manner

(2012) Yong Wang et al.   PLoS One

Let-7b Inhibits Human Cancer Phenotype by Targeting Cytochrome P450 Epoxygenase 2J2

(2012) Fuqiong Chen et al.   PLoS One

Ergosterol Peroxide Isolated from Ganoderma lucidum Abolishes MicroRNA miR-378-Mediated Tumor Cells on Chemoresistance

(2012) Qing-Ping Wu et al.   PLoS One

The impact of cellular senescence in cancer therapy: is it true or not?

(2011) Yi Zhang et al.   ACTA PHARMACOLOGICA SINICA

Macro-management of microRNAs in cell cycle progression of tumor cells and its implications in anti-cancer therapy

(2011) Lin-hui Liang et al.   ACTA PHARMACOLOGICA SINICA

MicroRNA-221 inhibits CDKN1C/p57 expression in human colorectal carcinoma

(2011) Kai Sun et al.   ACTA PHARMACOLOGICA SINICA

Bcl-2 Upregulation Induced by miR-21 Via a Direct Interaction Is Associated with Apoptosis and Chemoresistance in MIA PaCa-2 Pancreatic Cancer Cells

(2011) Jie Dong et al.   ARCHIVES OF MEDICAL RESEARCH

miRNA-34a is associated with docetaxel resistance in human breast cancer cells

(2011) L. Kastl et al.   BREAST CANCER RESEARCH AND TREATMENT

Targeting of the Tumor Suppressor GRHL3 by a miR-21-Dependent Proto-Oncogenic Network Results in PTEN Loss and Tumorigenesis

(2011) Charbel Darido et al.   CANCER CELL

MicroRNA Regulation of Cancer Stem Cells

(2011) C. Liu et al.   CANCER RESEARCH

Microparticles and their emerging role in cancer multidrug resistance

(2011) J. Gong et al.   CANCER TREATMENT REVIEWS

A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA

(2011) Marcella Cesana et al.   CELL

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression

(2011) Mikael Lerner et al.   CELL CYCLE

MiRNA-mediated regulation of cell signaling and homeostasis in the early mouse embryo

(2011) Barbara Pernaute et al.   CELL CYCLE

MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines

(2011) Giuditta Viticchiè et al.   CELL CYCLE

A non-coding transcript of nephronectin promotes osteoblast differentiation by modulating microRNA functions

(2011) Shao-Chen Lee et al.   FEBS LETTERS

Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1

(2011) Benjamin Boyerinas et al.   INTERNATIONAL JOURNAL OF CANCER

Homo sapiensSystemic RNA Interference-defective-1 Transmembrane Family Member 1 (SIDT1) Protein Mediates Contact-dependent Small RNA Transfer and MicroRNA-21-driven Chemoresistance

(2011) Mohamed O. Elhassan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA miR-199a-3p regulates cell proliferation and survival by targeting caveolin-2

(2011) T. Shatseva et al.   JOURNAL OF CELL SCIENCE

MicroRNA 376c enhances ovarian cancer cell survival by targeting activin receptor-like kinase 7: implications for chemoresistance

(2011) G. Ye et al.   JOURNAL OF CELL SCIENCE

MicroRNA-125b Induces Cancer Cell Apoptosis Through Suppression of Bcl-2 Expression

(2011) Aihua Zhao et al.   Journal of Genetics and Genomics

miR-34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo-sensitivity and malignancy

(2011) Fumihiko Nakatani et al.   JOURNAL OF PATHOLOGY

Down-regulation of microRNA-200c is associated with drug resistance in human breast cancer

(2011) Junqing Chen et al.   MEDICAL ONCOLOGY

EGFR Signals Downregulate Tumor Suppressors miR-143 and miR-145 in Western Diet-Promoted Murine Colon Cancer: Role of G1 Regulators

(2011) H. Zhu et al.   MOLECULAR CANCER RESEARCH

Liposomal Delivery of MicroRNA-7-Expressing Plasmid Overcomes Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor-Resistance in Lung Cancer Cells

(2011) K. Rai et al.   MOLECULAR CANCER THERAPEUTICS

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(2011) Yingchun Zhao et al.   MOLECULAR MEDICINE

A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells

(2011) Kim J. Png et al.   NATURE

miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response

(2011) Bogdan Mateescu et al.   NATURE MEDICINE

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

(2011) Can Liu et al.   NATURE MEDICINE

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs

(2011) E L McKinsey et al.   ONCOGENE

Regulation of miR-19 to Breast Cancer Chemoresistance Through Targeting PTEN

(2011) Zhongxing Liang et al.   PHARMACEUTICAL RESEARCH

Versican G3 Domain Modulates Breast Cancer Cell Apoptosis: A Mechanism for Breast Cancer Cell Response to Chemotherapy and EGFR Therapy

(2011) William Weidong Du et al.   PLoS One

MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1

(2011) William CS Cho et al.   RNA Biology

Involvement of microRNA-21 in mediating chemo-resistance to docetaxel in androgen-independent prostate cancer PC3 cells

(2010) Guo-hai Shi et al.   ACTA PHARMACOLOGICA SINICA

MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity

(2010) Lei Shi et al.   BRAIN RESEARCH

Oncogenic HER2Δ16 suppresses miR-15a/16 and deregulates BCL-2 to promote endocrine resistance of breast tumors

(2010) Diana M. Cittelly et al.   CARCINOGENESIS

miR-130b Promotes CD133+ Liver Tumor-Initiating Cell Growth and Self-Renewal via Tumor Protein 53-Induced Nuclear Protein 1

(2010) Stephanie Ma et al.   Cell Stem Cell

Gap junctions and connexins as therapeutic targets in cancer

(2010) Mustapha Kandouz et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

MiR-27a modulates MDR1/P-glycoprotein expression by targeting HIPK2 in human ovarian cancer cells

(2010) Zhimin Li et al.   GYNECOLOGIC ONCOLOGY

MiR-148a Attenuates Paclitaxel Resistance of Hormone-refractory, Drug-resistant Prostate Cancer PC3 Cells by Regulating MSK1 Expression

(2010) Yasunori Fujita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-125b Confers the Resistance of Breast Cancer Cells to Paclitaxel through Suppression of Pro-apoptotic Bcl-2 Antagonist Killer 1 (Bak1) Expression

(2010) Ming Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukaemia

(2010) Dan-Dan Feng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status

(2010) Xuan Zhou et al.   LABORATORY INVESTIGATION

Multiple Drug Resistance Mechanisms in Cancer

(2010) Bruce C. Baguley   MOLECULAR BIOTECHNOLOGY

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

Expression of CD44 3′-untranslated region regulates endogenous microRNA functions in tumorigenesis and angiogenesis

(2010) Zina Jeyapalan et al.   NUCLEIC ACIDS RESEARCH

De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures

(2010) A Ernst et al.   ONCOGENE

MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8

(2010) L Fang et al.   ONCOGENE

Human MicroRNA Oncogenes and Tumor Suppressors Show Significantly Different Biological Patterns: From Functions to Targets

(2010) Dong Wang et al.   PLoS One

Expression of Versican 3′-Untranslated Region Modulates Endogenous MicroRNA Functions

(2010) Daniel Y. Lee et al.   PLoS One

Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1

(2009) Zhongxing Liang et al.   BIOCHEMICAL PHARMACOLOGY

Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells

(2009) A. K. Ghosh et al.   BLOOD

MicroRNA regulates human vitamin D receptor

(2009) Takuya Mohri et al.   INTERNATIONAL JOURNAL OF CANCER

Hyaluronan-CD44 Interaction with Protein Kinase Cϵ Promotes Oncogenic Signaling by the Stem Cell Marker Nanog and the Production of MicroRNA-21, Leading to Down-regulation of the Tumor Suppressor Protein PDCD4, Anti-apoptosis, and Chemotherapy Resistance in Breast Tumor Cells

(2009) Lilly Y. W. Bourguignon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-138 might reverse multidrug resistance of leukemia cells

(2009) Xiaohong Zhao et al.   LEUKEMIA RESEARCH

MicroRNA-328 Negatively Regulates the Expression of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Cancer Cells

(2009) Y.-Z. Pan et al.   MOLECULAR PHARMACOLOGY

MicroRNA MiR-17 retards tissue growth and represses fibronectin expression

(2009) Sze Wan Shan et al.   NATURE CELL BIOLOGY

A 3′-Untranslated Region (3′UTR) Induces Organ Adhesion by Regulating miR-199a* Functions

(2009) Daniel Y. Lee et al.   PLoS One

MicroRNA miR-378 Regulates Nephronectin Expression Modulating Osteoblast Differentiation by Targeting GalNT-7

(2009) Shireen Kahai et al.   PLoS One

MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers

(2009) M. Seike et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice

(2009) A. Bonauer et al.   SCIENCE

Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells

(2008) Hua Zhu et al.   BIOCHEMICAL PHARMACOLOGY

CYP1B1 expression is induced by docetaxel: effect on cell viability and drug resistance

(2008) V G Martinez et al.   BRITISH JOURNAL OF CANCER

MicroRNA-221/222 Negatively Regulates Estrogen Receptorα and Is Associated with Tamoxifen Resistance in Breast Cancer

(2008) Jian-Jun Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin

(2008) O. Kovalchuk et al.   MOLECULAR CANCER THERAPEUTICS

miR2Disease: a manually curated database for microRNA deregulation in human disease

(2008) Q. Jiang et al.   NUCLEIC ACIDS RESEARCH

MicroRNA miR-328 Regulates Zonation Morphogenesis by Targeting CD44 Expression

(2008) Chia-Hui Wang et al.   PLoS One