Oncogenic HER2Δ16 suppresses miR-15a/16 and deregulates BCL-2 to promote endocrine resistance of breast tumors

An ER activity profile including ER, PR, Bcl-2 and IGF-IR may have potential as selection criterion for letrozole or tamoxifen treatment of patients with advanced breast cancer

(2009) Katrine L. Henriksen et al.   ACTA ONCOLOGICA

Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

(2009) M. H. Kang et al.   CLINICAL CANCER RESEARCH

An oncogenic isoform of HER2 associated with locally disseminated breast cancer and trastuzumab resistance

(2009) D. Mitra et al.   MOLECULAR CANCER THERAPEUTICS

Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells

(2009) Nalinie S. Wickramasinghe et al.   NUCLEIC ACIDS RESEARCH

MicroRNAs

(2008) Muller Fabbri et al.   CANCER JOURNAL

The HER4/4ICD Estrogen Receptor Coactivator and BH3-Only Protein Is an Effector of Tamoxifen-Induced Apoptosis

(2008) A. Naresh et al.   CANCER RESEARCH

Tamoxifen Resistance in Breast Tumors Is Driven by Growth Factor Receptor Signaling with Repression of Classic Estrogen Receptor Genomic Function

(2008) S. Massarweh et al.   CANCER RESEARCH

miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells

(2008) Lin Xia et al.   INTERNATIONAL JOURNAL OF CANCER

MicroRNA-221/222 Negatively Regulates Estrogen Receptorα and Is Associated with Tamoxifen Resistance in Breast Cancer

(2008) Jian-Jun Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-221/222 Confers Tamoxifen Resistance in Breast Cancer by Targeting p27Kip1

(2008) Tyler E. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small is beautiful: microRNAs and breast cancer-where are we now?

(2008) ET Verghese et al.   JOURNAL OF PATHOLOGY

Endogenous human microRNAs that suppress breast cancer metastasis

(2008) Sohail F. Tavazoie et al.   NATURE

The miR-15a–miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities

(2008) Désirée Bonci et al.   NATURE MEDICINE