Macro-management of microRNAs in cell cycle progression of tumor cells and its implications in anti-cancer therapy

miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells

(2015)   Oncotarget

Downregulation of miR-21 Enhances Chemotherapeutic Effect of Taxol in Breast Carcinoma Cells

(2014) Mei Mei et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Effects of microRNA-29 family members on proliferation and invasion of gastric cancer cell lines

(2012) Nan Lang et al.   Chinese Journal of Cancer

miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor

(2011) Jong-Kook Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma

(2011) J Buechner et al.   BRITISH JOURNAL OF CANCER

MicroRNA-301 Mediates Proliferation and Invasion in Human Breast Cancer

(2011) W. Shi et al.   CANCER RESEARCH

miR-137 Is Frequently Down-Regulated in Gastric Cancer and Is a Negative Regulator of Cdc42

(2011) Qingjiang Chen et al.   DIGESTIVE DISEASES AND SCIENCES

Elevated miR-155 Promotes Inflammation in Cystic Fibrosis by Driving Hyperexpression of Interleukin-8

(2011) Sharmistha Bhattacharyya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of microRNA-150 as a tumor suppressor in malignant lymphoma

(2011) A Watanabe et al.   LEUKEMIA

EGFR Signals Downregulate Tumor Suppressors miR-143 and miR-145 in Western Diet-Promoted Murine Colon Cancer: Role of G1 Regulators

(2011) H. Zhu et al.   MOLECULAR CANCER RESEARCH

MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways

(2011) C Oneyama et al.   ONCOGENE

MicroRNAs MiR-17, MiR-20a, and MiR-106b Act in Concert to Modulate E2F Activity on Cell Cycle Arrest during Neuronal Lineage Differentiation of USSC

(2011) Hans-Ingo Trompeter et al.   PLoS One

MicroRNAs as therapeutic targets in cancer

(2011) S. Patrick Nana-Sinkam et al.   Translational Research

miRNA-331-3p directly targets E2F1 and induces growth arrest in human gastric cancer

(2010) Xiaobo Guo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-1285 inhibits the expression of p53 by directly targeting its 3′ untranslated region

(2010) Shu Tian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras

(2010) Ki-Hyuk Shin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-221/222 suppression protects against endoplasmic reticulum stress-induced apoptosis via p27Kip1- and MEK/ERK-mediated cell cycle regulation

(2010) Rongyang Dai et al.   BIOLOGICAL CHEMISTRY

MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN

(2010) Zhang Chun-zhi et al.   BMC CANCER

MicroRNA-21 induces resistance to the anti-tumour effect of interferon-α/5-fluorouracil in hepatocellular carcinoma cells

(2010) Y Tomimaru et al.   BRITISH JOURNAL OF CANCER

Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21

(2010) Mark E. Hatley et al.   CANCER CELL

miRNA-96 Suppresses KRAS and Functions as a Tumor Suppressor Gene in Pancreatic Cancer

(2010) S. Yu et al.   CANCER RESEARCH

Myc-Induced MicroRNAs Integrate Myc-Mediated Cell Proliferation and Cell Fate

(2010) Jong Wook Kim et al.   CANCER RESEARCH

Regulation of Insulin-like Growth Factor–Mammalian Target of Rapamycin Signaling by MicroRNA in Childhood Adrenocortical Tumors

(2010) Mabrouka Doghman et al.   CANCER RESEARCH

Anti-miR-21 oligonucleotide sensitizes leukemic K562 cells to arsenic trioxide by inducing apoptosis

(2010) Yumin Li et al.   CANCER SCIENCE

Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis

(2010) Yutaka Hashimoto et al.   CARCINOGENESIS

Thelet-7microRNA reduces tumor growth in mouse models of lung cancer

(2010) Aurora Esquela-Kerscher et al.   CELL CYCLE

miR-129 regulates cell proliferation by downregulating Cdk6 expression

(2010) Junjie Wu et al.   CELL CYCLE

miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal

(2010) Antonio Herrera-Merchan et al.   CELL CYCLE

MicroRNA-193b regulates proliferation, migration and invasion in human hepatocellular carcinoma cells

(2010) Chengwang Xu et al.   EUROPEAN JOURNAL OF CANCER

MicroRNA mir-16 is anti-proliferative in enterocytes and exhibits diurnal rhythmicity in intestinal crypts

(2010) Anita Balakrishnan et al.   EXPERIMENTAL CELL RESEARCH

Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway

(2010) O. A. Kent et al.   GENES & DEVELOPMENT

Hsa-let-7g inhibits proliferation of hepatocellular carcinoma cells by downregulation of c-Myc and upregulation of p16INK4A

(2010) Fei-Fei Lan et al.   INTERNATIONAL JOURNAL OF CANCER

Polo-like kinase 1 regulates cell proliferation and is targeted by miR-593* in esophageal cancer

(2010) Tetsuo Ito et al.   INTERNATIONAL JOURNAL OF CANCER

MicroRNA-214 Promotes Myogenic Differentiation by Facilitating Exit from Mitosis via Down-regulation of Proto-oncogene N-ras

(2010) Jun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Co-delivery of as-miR-21 and 5-FU by Poly(amidoamine) Dendrimer Attenuates Human Glioma Cell Growth in Vitro

(2010) Yu Ren et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Down-regulation of cyclin E1 expression by microrna-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation

(2010) Yumiko Sekiya et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Down-Regulation of Wee1 Kinase by a Specific Subset of microRNA in Human Sporadic Pituitary Adenomas

(2010) Henriett Butz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc

(2010) Zhe Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma

(2010) Changzheng Liu et al.   JOURNAL OF HEPATOLOGY

Transcriptional Repression of miR-34 Family Contributes to p63-Mediated Cell Cycle Progression in Epidermal Cells

(2010) Dario Antonini et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Let-7 microRNA inhibits the proliferation of human glioblastoma cells

(2010) Soon-Tae Lee et al.   JOURNAL OF NEURO-ONCOLOGY

Functional genomics of tumor suppressor miR-196b in T-cell acute lymphoblastic leukemia

(2010) Suman Bhatia et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

miR-29a levels are elevated in the db/db mice liver and its overexpression leads to attenuation of insulin action on PEPCK gene expression in HepG2 cells

(2010) Amit K. Pandey et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2

(2010) Niamh H Foley et al.   Molecular Cancer

Negative Regulation of Tumor Suppressor p53 by MicroRNA miR-504

(2010) Wenwei Hu et al.   MOLECULAR CELL

p53 activates the PANK1/ miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins

(2010) Levin Böhlig et al.   NUCLEIC ACIDS RESEARCH

Upregulation of miR-21 by Ras in vivo and its role in tumor growth

(2010) D Frezzetti et al.   ONCOGENE

MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways

(2010) X Rao et al.   ONCOGENE

Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21Waf1/Cip1

(2010) V Borgdorff et al.   ONCOGENE

Cyclin-dependent kinase 1 expression is inhibited by p16INK4a at the post-transcriptional level through the microRNA pathway

(2010) W W Chien et al.   ONCOGENE

Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3′ untranslated region

(2010) S Wu et al.   ONCOGENE

MicroRNA Let-7a Inhibits Proliferation of Human Prostate Cancer Cells In Vitro and In Vivo by Targeting E2F2 and CCND2

(2010) Qingchuan Dong et al.   PLoS One

Targeting DNA-PKcs and ATM with miR-101 Sensitizes Tumors to Radiation

(2010) Dan Yan et al.   PLoS One

Expression of Versican 3′-Untranslated Region Modulates Endogenous MicroRNA Functions

(2010) Daniel Y. Lee et al.   PLoS One

ATM is down-regulated by N-Myc-regulated microRNA-421

(2010) H. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells

(2010) X. Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of differential and functionally active miRNAs in both anaplastic lymphoma kinase (ALK)+ and ALK- anaplastic large-cell lymphoma

(2010) O. Merkel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Down-regulation of microRNA 106b is involved in p21-mediated cell cycle arrest in response to radiation in prostate cancer cells

(2010) Baoqing Li et al.   PROSTATE

Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia

(2009) J. A. Pulikkan et al.   BLOOD

Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein   are targeted by miR-155 in B cells of E -MiR-155 transgenic mice

(2009) S. Costinean et al.   BLOOD

miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53

(2009) F. Navarro et al.   BLOOD

Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia

(2009) Y. Yamanaka et al.   BLOOD

MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma

(2009) A. M. Roccaro et al.   BLOOD

MiR-125b is critical for the suppression of human U251 glioma stem cell proliferation

(2009) Lei Shi et al.   BRAIN RESEARCH

miR-15a and miR-16 Are Implicated in Cell Cycle Regulation in a Rb-Dependent Manner and Are Frequently Deleted or Down-regulated in Non–Small Cell Lung Cancer

(2009) Nora Bandi et al.   CANCER RESEARCH

miR-34b Targets Cyclic AMP-Responsive Element Binding Protein in Acute Myeloid Leukemia

(2009) M. Pigazzi et al.   CANCER RESEARCH

microRNA-21 Negatively Regulates Cdc25A and Cell Cycle Progression in Colon Cancer Cells

(2009) P. Wang et al.   CANCER RESEARCH

Epigenetic Silencing of the Tumor Suppressor MicroRNA Hsa-miR-124a Regulates CDK6 Expression and Confers a Poor Prognosis in Acute Lymphoblastic Leukemia

(2009) X. Agirre et al.   CANCER RESEARCH

MicroRNA-34a Inhibits Glioblastoma Growth by Targeting Multiple Oncogenes

(2009) Y. Li et al.   CANCER RESEARCH

The miR-18a* microRNA functions as a potential tumor suppressor by targeting on K-Ras

(2009) Wing Pui Tsang et al.   CARCINOGENESIS

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

Phosphorylation of the Human MicroRNA-Generating Complex Mediates MAPK/Erk Signaling

(2009) Zain Paroo et al.   CELL

Hsa-miR-222 Is Involved in Differentiation of Endometrial Stromal Cellsin Vitro

(2009) Kun Qian et al.   ENDOCRINOLOGY

miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A

(2009) X. Yang et al.   GENES & DEVELOPMENT

MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells

(2009) Teng Xu et al.   HEPATOLOGY

let-7Overexpression Leads to an Increased Fraction of Cells in G2/M, Direct Down-regulation of Cdc34, and Stabilization of Wee1 Kinase in Primary Fibroblasts

(2009) Aster Legesse-Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice

(2009) Xiao-yan He et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

miR-24 Inhibits Cell Proliferation by Targeting E2F2, MYC, and Other Cell-Cycle Genes via Binding to “Seedless” 3′UTR MicroRNA Recognition Elements

(2009) Ashish Lal et al.   MOLECULAR CELL

Systemic Delivery of Synthetic MicroRNA-16 Inhibits the Growth of Metastatic Prostate Tumors via Downregulation of Multiple Cell-cycle Genes

(2009) Fumitaka Takeshita et al.   MOLECULAR THERAPY

Role of miR-143 targeting KRAS in colorectal tumorigenesis

(2009) X Chen et al.   ONCOGENE

MiR-24 Tumor Suppressor Activity Is Regulated Independent of p53 and through a Target Site Polymorphism

(2009) Prasun J. Mishra et al.   PLoS One

MicroRNA 92b Controls the G1/S Checkpoint Gene p57 in Human Embryonic Stem Cells

(2009) Srikumar Sengupta et al.   STEM CELLS

MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes

(2008) M. Inomata et al.   BLOOD

E2F1-Regulated MicroRNAs Impair TGFβ-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer

(2008) Fabio Petrocca et al.   CANCER CELL

MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth

(2008) Julia Schultz et al.   CELL RESEARCH

miR-192 Regulates Dihydrofolate Reductase and Cellular Proliferation through the p53-microRNA Circuit

(2008) B. Song et al.   CLINICAL CANCER RESEARCH

Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest

(2008) Fang Sun et al.   FEBS LETTERS

The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers

(2008) Chunguang Guo et al.   GENES CHROMOSOMES & CANCER

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Diagnostic and prognostic implications of microRNAs in human hepatocellular carcinoma

(2008) Wenxi Li et al.   INTERNATIONAL JOURNAL OF CANCER

MicroRNA Expression Profiles Associated With Prognosis and Therapeutic Outcome in Colon Adenocarcinoma

(2008) Aaron J. Schetter et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

MicroRNA-221/222 Confers Tamoxifen Resistance in Breast Cancer by Targeting p27Kip1

(2008) Tyler E. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation

(2008) Zuoren Yu et al.   JOURNAL OF CELL BIOLOGY

MicroRNA-128 inhibits glioma cells proliferation by targeting transcription factor E2F3a

(2008) Yu Zhang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Oct4/Sox2-Regulated miR-302 Targets Cyclin D1 in Human Embryonic Stem Cells

(2008) D. A. Greer Card et al.   MOLECULAR AND CELLULAR BIOLOGY

A Functional Screen Identifies miR-34a as a Candidate Neuroblastoma Tumor Suppressor Gene

(2008) K. A. Cole et al.   MOLECULAR CANCER RESEARCH

miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes

(2008) Q. Liu et al.   NUCLEIC ACIDS RESEARCH

miR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression

(2008) M T Pickering et al.   ONCOGENE

p16INK4a Translation Suppressed by miR-24

(2008) Ashish Lal et al.   PLoS One

miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130

(2008) Q. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of non-small cell lung tumor development by the let-7 microRNA family

(2008) M. S. Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition

(2008) Nicole Cloonan et al.   GENOME BIOLOGY