Article
Cell Biology
Heizel Rosado-Galindo, Maribella Domenech
Summary: This study demonstrates that surface roughness can influence oncogenic activity in triple-negative breast cancer (TNBC) cells and enrich cancer stem cell (CSC) populations in planar cultures.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Carolin Selenz, Anik Compes, Marieke Nill, Sven Borchmann, Margarete Odenthal, Alexandra Florin, Johannes Braegelmann, Reinhard Buettner, Lydia Meder, Roland T. Ullrich
Summary: EGFR inhibition promotes immune cell infiltration in the tumour microenvironment and enhances response to immune checkpoint inhibitors in EGFR-driven lung cancer.
Review
Cell Biology
Rebar N. Mohammed, Mohsen Khosravi, Heshu Sulaiman Rahman, Ali Adili, Navid Kamali, Pavel Petrovich Soloshenkov, Lakshmi Thangavelu, Hossein Saeedi, Navid Shomali, Rozita Tamjidifar, Alireza Isazadeh, Ramin Aslaminabad, Morteza Akbari
Summary: Balanced cell death and survival pathways, including anastasis, play a critical role in cell development and homeostasis. Anastasis is a natural cell recovery pathway that promotes the survival of damaged or tumor cells, and contributes to the development of malignancy and drug resistance.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Multidisciplinary Sciences
Zainab Lafi, Walhan Alshaer, Lobna Gharaibeh, Dana A. Alqudah, Baidaa Alquaissi, Banan Bashaireh, Abed Alqader Ibrahim
Summary: Disulfiram and hydralazine have been found to have anti-cancer effects and have been repositioned as adjuvants in cancer therapy. This study evaluated the triple combination of doxorubicin, hydrazine, and disulfiram against wild-type and doxorubicin-resistant MCF-7 breast cancer cells. The results showed that the triple combination reduced drug resistance and enhanced chemosensitivity to doxorubicin in the cancer cells.
Article
Cell Biology
Ting Zhuang, Beibei Wang, Xiaojing Tan, Le Wu, Xin Li, Zhongbo Li, Yuqing Cai, Rongrong Fan, Xiao Yang, Chenmiao Zhang, Yan Xia, Zhiguo Niu, Bingtian Liu, Qi Cao, Yinlu Ding, Zhipeng Zhou, Qingsong Huang, Huijie Yang
Summary: In this study, the researchers found that TRIM3, an E3 ligase, promotes ER alpha signaling activity and breast cancer progression. Depletion of TRIM3 inhibits breast cancer cell proliferation and migration, and unbiased RNA sequencing data showed that TRIM3 is crucial for estrogen signaling activity on a genome-wide scale. The researchers also demonstrated that TRIM3 associates with ER alpha and promotes its stability by inducing a specific ubiquitin modification. These findings provide a novel posttranslational mechanism in estrogen signaling and suggest that modulation of TRIM3 expression or function could be a promising approach for breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Pharmacology & Pharmacy
Serah Kimani, Suparna Chakraborty, Ikponmwosa Irene, Jo de la Mare, Adrienne Edkins, Andre du Toit, Ben Loos, Angelique Blanckenberg, Annick Van Niekerk, Leticia Costa-Lotufo, K. N. ArulJothi, Selwyn Mapolie, Sharon Prince
Summary: The study investigated the anti-cancer activity of a palladium complex, BTC2, in human breast cancer cells, demonstrating its selectivity, inhibition of cancer cell migration, and suppression of cancer stem cell activity. BTC2 also induced DNA double strand breaks, triggered cell cycle arrests, and activated multiple cell death pathways, showing promising anti-breast cancer activity both in vitro and in vivo.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Brendan T. Graff, Chitra Palanivel, Christopher B. Jenkins, Janina Baranowska-Kortylewicz, Ying Yan
Summary: Metastatic breast cancer (mBC) is responsible for >90% of breast cancer-related deaths. The effectiveness of microtubule-targeting agents (MTAs) in mBC treatment is limited by primary or acquired resistance. This study evaluated the potential of methyl N-(6-benzoyl-1H-benzimidazol-2-yl)carbamate (BCar) as a novel MTA for MTA-resistant mBC. The results showed that BCar selectively killed breast cancer cells and had a wider therapeutic window compared to clinical MTAs docetaxel and vincristine.
CELL DEATH DISCOVERY
(2023)
Article
Chemistry, Physical
Barbara Zbiral, Andreas Weber, Jagoba Iturri, Maria D. M. Vivanco, Jose L. Toca-Herrera
Summary: The study found that estrogen softens MCF-7 breast cancer cells, while cells in hormone-free medium lead to an increase in elastic and viscoelastic moduli. Additionally, cells cultured under estrogenic conditions show changes in E-cadherin distribution and weakened cell-cell contacts.
Article
Biochemistry & Molecular Biology
Yi-Fen Chiang, Ko-Chieh Huang, Hsin-Yuan Chen, Tsui-Chin Huang, Mohamed Ali, Hsin-Yi Chang, Tzong-Ming Shieh, Yin-Hwa Shih, Kai-Lee Wang, Yun-Ju Huang, Cheng-Pei Chung, Shih-Min Hsia
Summary: Obesity is a risk factor for cancer progression as it increases adipokine secretion. Visfatin, a novel adipokine highly expressed in cancer patients, is associated with breast cancer risk. In this study, the effect of visfatin on stemness-related properties in high-malignancy breast cancer cells was investigated. Visfatin treatment significantly increased sphere formation, protein expression of stemness markers, and angiogenesis markers. These effects were reduced by the visfatin inhibitor FK866. The results suggest that visfatin promotes breast cancer stemness and enriches the tumorigenic microenvironment.
Article
Oncology
Mengzhao Wang, James Chih-Hsin Yang, Paul L. Mitchell, Jian Fang, D. Ross Camidge, Weiqi Nian, Chao-Hua Chiu, Jianying Zhou, Yanqiu Zhao, Wu-Chou Su, Tsung-Ying Yang, Viola W. Zhu, Michael Millward, Yun Fan, Wen-Tsung Huang, Ying Cheng, Liyan Jiang, Daniel Brungs, Lyudmila Bazhenova, Chee Khoon Lee, Bo Gao, Yan Xu, Wei-Hsun Hsu, Li Zheng, Pasi A. Janne
Summary: This article reports the discovery and early clinical development of Sunvozertinib (DZD9008), a potential treatment option for EGFRexon20ins NSCLC.
Article
Oncology
Marine Lemesle, Marine Geoffroy, Fabien Alpy, Catherine-Laure Tomasetto, Sandra Kuntz, Isabelle Grillier-Vuissoz
Summary: This study investigated the role of CLDN1 in triple-negative breast cancer (TNBC) and found that CLDN1 can increase the sensitivity of TNBC cells to chemotherapy drugs. The findings support the use of CLDN1 as a predictive marker for chemotherapy response in TNBC.
Article
Medicine, Research & Experimental
Tianfeng Yang, Runze Yu, Cheng Cheng, Jian Huo, Zhengyan Gong, Hanbing Cao, Yu Hu, Bingling Dai, Yanmin Zhang
Summary: This study reveals that cantharidin may be a potential candidate for TNBC treatment by downregulating EGFR through miR-607. It inhibits TNBC cell growth and induces apoptosis. Mechanistic study shows that cantharidin blocks the downstream PI3K/AKT/mTOR and ERK/MAPK signaling pathways.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Yongxiu Huang, Hongyao Peng, Anqi Zeng, Linjiang Song
Summary: Breast cancer is the most common malignant tumor in women, and its incidence is increasing. Chemotherapy is widely used as a treatment for breast cancer, but drug resistance poses a challenge. Peptides have shown promise in overcoming drug resistance in breast cancer cells through various mechanisms such as promoting apoptosis, inhibiting DNA repair, and improving the tumor microenvironment. Understanding the mechanisms of peptides in reversing drug resistance could lead to breakthroughs in breast cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Xia Liu, Valery Adorno-Cruz, Ya-Fang Chang, Yuzhi Jia, Madoka Kawaguchi, Nurmaa K. Dashzeveg, Rokana Taftaf, Erika K. Ramos, Emma J. Schuster, Lamiaa El-Shennawy, Dhwani Patel, Youbin Zhang, Massimo Cristofanilli, Huiping Liu
Summary: Research has shown that inhibiting EGFR can block the circulating cancer stem cell (cCSC) clustering and lung metastasis of triple-negative breast cancer (TNBC). In addition to CD44, microRNA-30c also plays a negative regulatory role in cCSC clustering and lung metastasis.
Article
Chemistry, Multidisciplinary
Manar G. Salem, Sara A. Abu El-ata, Elsherbiny H. Elsayed, Suraj N. Mali, Hussah Abdullah Alshwyeh, Ghassan Almaimani, Riyad A. Almaimani, Hussain A. Almasmoum, Najla Altwaijry, Ebtesam Al-Olayan, Essa M. Saied, Mohamed F. Youssef
Summary: Breast cancer is a global health concern with limited treatment options in underserved areas. In this study, a novel family of compounds was developed and evaluated for their inhibitory activity against breast cancer cells. Compound 3b showed significant inhibitory effect and minimal impact on normal cells. Mechanistic studies revealed the involvement of cell cycle regulation and targeting of topoisomerase II and EGFR activity by compound 3b.
Article
Biochemical Research Methods
Sze Wan Shan, Chi Wai Do, Thomas Chuen Lam, Ricky Pak Wing Kong, King Kit Li, Ka Man Chun, William Daniel Stamer, Chi Ho To
JOURNAL OF PROTEOME RESEARCH
(2017)
Article
Biochemical Research Methods
Sze Wan Shan, Dennis Yan-yin Tse, Bing Zuo, Chi Ho To, Quan Liu, Sally A. McFadden, Rachel Ka-Man Chun, Jingfang Bian, King Kit Li, Thomas Chuen Lam
JOURNAL OF PROTEOMICS
(2018)
Article
Multidisciplinary Sciences
Lisa Yan-yan Xi, Shea Ping Yip, Sze Wan Shan, Jody Summers-Rada, Chea-Su Kee
SCIENTIFIC REPORTS
(2017)
Article
Biochemical Research Methods
Feng-Juan Yu, Thomas Chuen Lam, Andes Ying-Hon Sze, King-Kit Li, Rachel Ka-Man Chun, Sze-Wan Shan, Chi-Ho To
JOURNAL OF PROTEOMICS
(2020)
Article
Cell Biology
Samuel Abokyi, Sze Wan Shan, Chi-ho To, Henry Ho-lung Chan, Dennis Yan-yin Tse
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Biophysics
Ying Xin, Byung Soo Kang, Yong-Ping Zheng, Sze Wan Shan, Chea-Su Kee, Youhua Tan
Summary: This study found that during the progression of myopia, there are significant changes in the biophysical properties of corneal cells, including reduced F-actin and microtubule content, decreased cellular stiffness, increased traction force, and increased chromatin condensation level. These changes partially or fully recover when myopia is restored to a healthy state. The reversible biophysical alterations of corneal cells reflect the progression of myopia.
BIOPHYSICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Samuel Abokyi, Sze-Wan Shan, Christie Hang- Lam, Kirk Patrick Catral, Feng Pan, Henry Ho-Lung Chan, Chi-Ho To, Dennis Yan-Yin Tse
Summary: This study found that lysosomal dysfunction and autophagy defects underlie oxidative damage induced by HQ in human RPE cells, and supports lysosomal stabilization with the proteasome inhibitor MG132 as a potential remedy for oxidative damage in RPE and AMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Sze-Wan Shan, Chi-Wai Do, Thomas Chuen Lam, Hoi-Lam Li, W. Daniel Stamer, Chi-Ho To
Summary: The selective ROCK inhibitor Y39983 induces actin remodeling, decreases cell motility and transepithelial resistance in human TM cells. Proteomic analysis identified 20 significantly altered proteins after Y39983 treatment, involving pathways such as p53, integrin signaling, and cytoskeletal regulation by Rho GTPase. Downregulation of TSP1 by Y39983 and its antagonists led to reduced cell migration and increased outflow facility.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hoi-lam Li, Sze Wan Shan, W. Daniel Stamer, King-kit Li, Henry Ho-lung Chan, Mortimer M. Civan, Chi-ho To, Thomas Chuen Lam, Chi-wai Do
Summary: Baicalein (Ba) can lower intraocular pressure (IOP) by regulating trabecular meshwork (TM) cell function, extracellular matrix (ECM) deposition, and protein expression, leading to improved fluid drainage and reduced IOP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ka-Lok Li, Sze-Wan Shan, Fang-Yu Lin, Choi-Ying Ling, Nga-Wai Wong, Hoi-Lam Li, Wei Han, Chi-Ho To, Chi-Wai Do
Summary: The study found that melatonin has a significant impact on the secretion of aqueous humor in porcine ciliary epithelium. It stimulates the movement of Cl- and fluid from pigmented cells to non-pigmented cells through the activation of MT3 receptors, thereby increasing aqueous humor secretion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sze Wan Shan, Pan Feng Wang, Jimmy Ka Wai Cheung, Fengjuan Yu, Hui Zheng, Shumeng Luo, Shea Ping Yip, Chi Ho To, Thomas Chuen Lam
Summary: This study examined the gene expression of the chicken retina during the early development of lens-induced myopia using whole transcriptome sequencing. The results suggest that concerted changes in retinal gene expression may play a key role in the initiation of axial elongation and myopia development.
Article
Neurosciences
Seema Banerjee, Qing Wang, George Tang, ChungHim So, Sze Wan Shan, King Kit Li, Chi-Wai Do, Feng Pan
Summary: Our study demonstrated an increase in phosphorylation of connexin35 at Ser276 in both 12-hour and 7-day stages of lens-induced myopia in cone-dominant chicken retinas, potentially leading to increased coupling with AII amacrine cells.
VISUAL NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Sze-Wan Shan, Chi-Wai Do, Thomas Chuen Lam, Hoi-Lam Li, W. Daniel Stamer, Chi-Ho To
Article
Multidisciplinary Sciences
Sze Wan Shan, Dennis Yan-yin Tse, Bing Zuo, Chi Ho To, Quan Liu, Sally A. McFadden, Rachel Ka-Man Chun, Jingfang Bian, King Kit Li, Thomas Chuen Lam
Article
Ophthalmology
Stanley Ka-Lok Li, Sze-Wan Shan, Hoi-Lam Li, Angela King-Wah Cheng, Feng Pan, Shea-Ping Yip, Mortimer M. Civan, Chi-Ho To, Chi-Wai Do
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2018)