Review
Medicine, Research & Experimental
Yawei Bi, Xiao Lei, Ningli Chai, Enqiang Linghu
Summary: NOX4 is upregulated in pancreatic cancer and primarily produces hydrogen peroxide, exhibiting different properties from other NOX family subtypes. Recent studies suggest that NOX4 promotes pancreatic cancer occurrence and development, making it a potential therapeutic target in pancreatic cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ildiko Szanto
Summary: Cancer cells can adapt to hypoxic environments through metabolic rewiring and synthesis of antioxidant molecules. NOX4, a member of the NOX family enzymes, plays a key role in the oncogenic metabolic adaptation of cancer cells by regulating diverse metabolic processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Danling Cheng, Xiaoying Wang, Xiaojun Zhou, Jingchao Li
Summary: Immunotherapy is a promising strategy for cancer treatment, but it faces challenges of low immune responses and immune-related adverse events. Sonodynamic therapy combined with immunotherapy can enhance antitumor immunity, and research on nanosonosensitizers for ROS generation is ongoing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Chenyang Zhang, Xin Wang, Xinghua Dong, Linqiang Mei, Xiaochen Wu, Zhanjun Gu, Yuliang Zhao
Summary: The proposed methodology accelerates the enzymatic activity of nanomaterials for tumor therapy by enhancing redox cycling in the presence of X-ray. The nanocomposite under external X-ray irradiation persists in generating ROS, indicating a synergistic effect for cancer treatment.
Review
Chemistry, Multidisciplinary
Yingbo Li, Jie Yang, Xilin Sun
Summary: Advancements in nanotechnology for cancer therapy have led to the development of nanomaterials that specifically generate cytotoxic reactive oxygen species (ROS) in tumor cells. These materials disturb the redox balance in tumor cells, leading to oxidative damage of DNA and proteins.
FRONTIERS IN CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Juan-Hua Quan, Fei Fei Gao, Jia-Qi Chu, Guang-Ho Cha, Jae-Min Yuk, Weiyun Wu, Young-Ha Lee
Summary: Silver nanoparticles (AgNPs) demonstrate anticancer effects against colorectal cancer through inducing mitochondrial reactive oxygen species production, mitochondrial dysfunction, and endoplasmic reticulum stress responses, leading to cell apoptosis.
Article
Biochemistry & Molecular Biology
Nicholas J. Lyons, Rabina Giri, Jakob Begun, David Clark, David Proud, Yaowu He, John D. Hooper, Thomas Kryza
Summary: This article discusses the role of reactive oxygen species (ROS) in normal and malignant colonic cell biology and explores how existing and emerging therapies can utilize ROS for therapeutic benefit. Recent research has shed light on the contribution of ROS to the cytotoxicity of conventional chemotherapy, as well as the generation of ROS in response to excitatory stimuli in emerging therapies such as photodynamic therapy, sonodynamic therapy, and radiodynamic therapy. However, the poor prognosis and resistance associated with metastatic colorectal cancer necessitate the development of new and more effective treatments.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Medicine, Research & Experimental
Zhan-zhao Liu, Xian-xian Duan, Meng-ci Yuan, Jing Yu, Xiao Hu, Xiao Han, Lan Lan, Bo-wei Liu, Yue Wang, Jun-fang Qin
Summary: This study found that liraglutide, at a specific concentration, could promote the malignant progression of breast cancer through activating GLP-1R, potentially exacerbating the risk of triple negative breast cancer. Therefore, the dosage and the phenotype of breast cancer should be considered when administering antidiabetic drugs.
Article
Biochemistry & Molecular Biology
Ruifeng Ji, Dou Wu, Qiang Liu
Summary: ICA has been found to inhibit the expression of genes and molecules related to osteoclastogenesis and reduce reactive oxygen species production in induced osteoclasts. These findings suggest that ICA has the potential to be used as a therapeutic agent for osteolytic diseases such as osteoporosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Xiaoen Shi, Haizhen Guo, Xinlu Zhang, Xu Zhang, Chen Cao, Huan Li, Shutong Chen, Lei Han, Sheng Wang
Summary: Photodynamic therapy (PDT) is limited by tumor oxygen heterogeneity, but a novel oxygen level-responsive nanomedicine is reported here. This nanomedicine consists of a hypoxia-responsive molecule (Cy-NO2), a radical generator (ADVN), and a pH-responsive polymer. Under normoxic conditions, Cy-NO2 acts as a photosensitizer for effective PDT, while under hypoxic conditions, it transforms into a photothermal agent to generate toxic free radicals for thermodynamic therapy. This study offers a promising strategy for smart cancer therapy by overcoming oxygen heterogeneity.
ACS MATERIALS LETTERS
(2023)
Article
Endocrinology & Metabolism
Jun-Chi Yu, Jia-Zhi Lu, Xiao-Yu Cui, Lei Guo, Zhi-Jun Wang, Yu-Dong Liu, Feng Wang, Ming-Fang Qi, Yu-Feng Liu, Tian-Lai Li
Summary: The study revealed that melatonin regulates ROS homeostasis and delays leaf aging in tomato plants through the modulation of SlCV gene expression.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Flavia Rezende, Pedro Felipe Malacarne, Niklas Mueller, Birgit Rathkolb, Martin Hrabe de Angelis, Katrin Schroeder, Ralf P. Brandes
Summary: The study found that Nox4 knockout mice exhibited similar weight loss and sodium sparing function under a low sodium diet, but showed reduced systolic blood pressure, heart-rate ratio, and heart to body weight ratio compared to wild-type mice, indicating that Nox4 plays a role in blood pressure regulation induced by low sodium diets.
Review
Chemistry, Inorganic & Nuclear
Jiale Liu, Mengyao Huang, Xinyu Zhang, Zhongyu Hua, Zeran Feng, Yi Dong, Tiedong Sun, Xiao Sun, Chunxia Chen
Summary: The dual effects of reactive oxygen species (ROS) in living organisms, which can cause oxidative imbalances and be regulated to attack tumors and bacteria, have attracted significant research attention. Polyoxometalates (POMs) have shown great potential in modulating ROS and have been investigated for disease treatment and sensing diagnostics, providing valuable insights into therapeutic and diagnostic technologies.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Medicine, Research & Experimental
Junlong Zhong, Bin Wang, Biao Wu, Jie Shang, Ning Jiang, Aiyong Cui, Yufeng Chen, Xianghe Xu, Huading Lu
Summary: This study found that Clock expression is up-regulated in OA cartilage and Clock knockdown can attenuate ROS-mediated chondrocyte senescence by restoring autophagic flux, providing a potential therapeutic target for OA.
Article
Biochemistry & Molecular Biology
Ching-Wen Liu, Po-Hen Chen, Tsan-Jung Yu, Kai-Jen Lin, Li-Ching Chang
Summary: The tumor-suppressor gene WWOX regulates reactive oxygen species (ROS) and cell senescence by activating p21/p27 and increasing intercellular ROS generation, inhibiting bladder tumor growth.