Numb prevents a complete epithelial–mesenchymal transition by modulating Notch signalling

The GRHL2/ZEB Feedback Loop-A Key Axis in the Regulation of EMT in Breast Cancer

(2017) Steven M. Mooney et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells

(2017) Brian Bierie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Numb and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial identity, and support lactogenesis

(2016) Yue Zhang et al.   FASEB JOURNAL

Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype

(2016) Marcelo Boareto et al.   Journal of the Royal Society Interface

CTC clusters in cancer progression and metastasis

(2016) Anna Fabisiewicz et al.   MEDICAL ONCOLOGY

Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome

(2016) Satyendra C. Tripathi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A collective route to metastasis: Seeding by tumor cell clusters

(2016) K. J. Cheung et al.   SCIENCE

Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy

(2016) José M. García-Heredia et al.   Oncotarget

Stability of the hybrid epithelial/mesenchymal phenotype

(2016) Mohit Kumar Jolly et al.   Oncotarget

NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling

(2016) Jianchao Zhang et al.   Oncotarget

Tumor Budding: The Name is EMT. Partial EMT.

(2016) Alexandru Grigore et al.   Journal of Clinical Medicine

Molecular Portraits of Epithelial, Mesenchymal, and Hybrid States in Lung Adenocarcinoma and Their Relevance to Survival

(2015) M. J. Schliekelman et al.   CANCER RESEARCH

ΔNp63α Promotes Breast Cancer Cell Motility through the Selective Activation of Components of the Epithelial-to-Mesenchymal Transition Program

(2015) Tuyen T. Dang et al.   CANCER RESEARCH

Stemness of the hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor Survival

(2015) Anne Grosse-Wilde et al.   PLoS One

Jagged–Delta asymmetry in Notch signaling can give rise to a Sender/Receiver hybrid phenotype

(2015) Marcelo Boareto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States

(2015) Tian Hong et al.   PLoS Computational Biology

Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis

(2015) Mohit Kumar Jolly   Frontiers in Oncology

PROGgeneV2: enhancements on the existing database

(2015) Chirayu Pankaj Goswami et al.   BMC CANCER

The tumor suppressive role of NUMB isoform 1 in esophageal squamous cell carcinoma

(2015) Junmou Hong et al.   Oncotarget

Tumor-Suppressive Activity of Lunatic Fringe in Prostate through Differential Modulation of Notch Receptor Activation

(2015) Shubing Zhang et al.   NEOPLASIA

Network Modeling of TGF  Signaling in Hepatocellular Carcinoma Epithelial-to-Mesenchymal Transition Reveals Joint Sonic Hedgehog and Wnt Pathway Activation

(2014) S. N. Steinway et al.   CANCER RESEARCH

NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer

(2014) Angela N. Flores et al.   Nature Reviews Urology

Numb Promotes Cell Proliferation and Correlates with Poor Prognosis in Hepatocellular Carcinoma

(2014) Jian Wu et al.   PLoS One

The Notch ligand Jagged1 as a target for anti-tumor therapy

(2014) Demin Li   Frontiers in Oncology

Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1

(2013) Jia Lu et al.   CANCER CELL

Regulation of Lung Cancer Metastasis by Klf4-Numb-like Signaling

(2013) V. Vaira et al.   CANCER RESEARCH

A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells

(2013) Pengcheng Bu et al.   Cell Stem Cell

Lunatic Fringe Deficiency Cooperates with the Met/Caveolin Gene Amplicon to Induce Basal-like Breast Cancer

(2012) Keli Xu et al.   CANCER CELL

Hybrid Models and Biological Model Reduction with PyDSTool

(2012) Robert Clewley   PLoS Computational Biology

Numblike and Numb differentially affect p53 and Sonic Hedgehog signaling

(2011) Lining Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

(2011) Nilay Sethi et al.   CANCER CELL

From Notch signaling to fine-grained patterning: Modeling meets experiments

(2011) O Shaya et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Numb controls E-cadherin endocytosis through p120 catenin with aPKC

(2011) Kazuhide Sato et al.   MOLECULAR BIOLOGY OF THE CELL

NUMB-ing down cancer by more than just a NOTCH

(2010) Salvatore Pece et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Gene expression profiling of drug-resistant small cell lung cancer cells by combining microRNA and cDNA expression analysis

(2010) Linlang Guo et al.   EUROPEAN JOURNAL OF CANCER

Numb is a negative regulator of HGF dependent cell scattering and Rac1 activation

(2010) Kimberly M. Lau et al.   EXPERIMENTAL CELL RESEARCH

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

(2010) A Singh et al.   ONCOGENE

Notch signaling specifies prosensory domains via lateral induction in the developing mammalian inner ear

(2010) B. H. Hartman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Numb regulates cell–cell adhesion and polarity in response to tyrosine kinase signalling

(2009) Zezhou Wang et al.   EMBO JOURNAL

Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer

(2009) R. A. Neumuller et al.   GENES & DEVELOPMENT

Ectopic expression of Ligand-of-Numb protein X promoted TGF-β induced epithelial to mesenchymal transition of proximal tubular epithelial cells

(2008) Jing Nie et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

(2008) Kyle Niessen et al.   JOURNAL OF CELL BIOLOGY

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

(2008) C. Sahlgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA