Phenotypic Plasticity and Cell Fate Decisions in Cancer: Insights from Dynamical Systems Theory

EMT and MET: necessary or permissive for metastasis?

(2017) Mohit Kumar Jolly et al.   Molecular Oncology

Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state

(2017) Mohammad Fallahi‐Sichani et al.   Molecular Systems Biology

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

(2017) Sydney M. Shaffer et al.   NATURE

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity

(2017) Prakash Kulkarni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells

(2017) Brian Bierie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interrogating the topological robustness of gene regulatory circuits by randomization

(2017) Bin Huang et al.   PLoS Computational Biology

Targeting the Metabolic Reprogramming That Controls Epithelial-to-Mesenchymal Transition in Aggressive Tumors

(2017) Andrea Morandi et al.   Frontiers in Oncology

Chemotherapy induces adaptive drug resistance and metastatic potentials via phenotypic CXCR4-expressing cell state transition in ovarian cancer

(2017) Hyun Hee Lee et al.   PLoS One

Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma

(2017) José L. Neira et al.   Scientific Reports

Phenotypic plasticity in prostate cancer: role of intrinsically disordered proteins

(2016) StevenM Mooney et al.   ASIAN JOURNAL OF ANDROLOGY

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype

(2016) Marcelo Boareto et al.   Journal of the Royal Society Interface

Grainyhead-like 2 Reverses the Metabolic Changes Induced by the Oncogenic Epithelial-Mesenchymal Transition: Effects on Anoikis

(2016) J. C. Farris et al.   MOLECULAR CANCER RESEARCH

Order, Disorder, and Everything in Between

(2016) Shelly DeForte et al.   MOLECULES

Quantifying the landscape and kinetic paths for epithelial–mesenchymal transition from a core circuit

(2016) Chunhe Li et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome

(2016) Satyendra C. Tripathi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial-mesenchymal transition in glioblastoma progression

(2016) YASUO IWADATE   Oncology Letters

Stability of the hybrid epithelial/mesenchymal phenotype

(2016) Mohit Kumar Jolly et al.   Oncotarget

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

(2016) Jun Hyoung Park et al.   Cell Reports

Phenotypic Plasticity Determines Cancer Stem Cell Therapeutic Resistance in Oral Squamous Cell Carcinoma

(2016) Adrian Biddle et al.   EBioMedicine

Tumor Budding: The Name is EMT. Partial EMT.

(2016) Alexandru Grigore et al.   Journal of Clinical Medicine

ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer

(2016) Takeshi Yoshida et al.   PLoS One

Epithelial–mesenchymal transition induces similar metabolic alterations in two independent breast cancer cell lines

(2015) Yuvabharath Kondaveeti et al.   CANCER LETTERS

Tumors and Mitochondrial Respiration: A Neglected Connection

(2015) Andrea Viale et al.   CANCER RESEARCH

Quantifying the Landscape for Development and Cancer from a Core Cancer Stem Cell Circuit

(2015) C. Li et al.   CANCER RESEARCH

Essential Role for Oxidative Phosphorylation in Cancer Progression

(2015) Maria Chiara Maiuri et al.   Cell Metabolism

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stemness of the hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor Survival

(2015) Anne Grosse-Wilde et al.   PLoS One

Endogenous molecular-cellular hierarchical modeling of prostate carcinogenesis uncovers robust structure

(2015) Xiaomei Zhu et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression

(2015) Xin Ye et al.   TRENDS IN CELL BIOLOGY

Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition

(2015) Aaron Goldman et al.   Nature Communications

OVOL guides the epithelial-hybrid-mesenchymal transition

(2015) Dongya Jia et al.   Oncotarget

Coupling the modules of EMT and stemness: A tunable ‘stemness window’ model

(2015) Mohit Kumar Jolly et al.   Oncotarget

An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States

(2015) Tian Hong et al.   PLoS Computational Biology

Editorial: Cellular and Phenotypic Plasticity in Cancer

(2015) Petranel T. Ferrao et al.   Frontiers in Oncology

Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis

(2015) Mohit Kumar Jolly   Frontiers in Oncology

Phenotype Switching in Melanoma: Implications for Progression and Therapy

(2015) Frederic Zhentao Li et al.   Frontiers in Oncology

Tumor Cells Switch to Mitochondrial Oxidative Phosphorylation under Radiation via mTOR-Mediated Hexokinase II Inhibition - A Warburg-Reversing Effect

(2015) Chung-Ling Lu et al.   PLoS One

Cancer/Testis Antigen PAGE4, a Regulator of c-Jun Transactivation, Is Phosphorylated by Homeodomain-Interacting Protein Kinase 1, a Component of the Stress-Response Pathway

(2014) Steven M. Mooney et al.   BIOCHEMISTRY

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

(2014) Nicola Aceto et al.   CELL

Reinforcing targeted therapeutics with phenotypic stability factors

(2014) Paul Yaswen   CELL CYCLE

Mammary Morphogenesis and Regeneration Require the Inhibition of EMT at Terminal End Buds by Ovol2 Transcriptional Repressor

(2014) Kazuhide Watanabe et al.   DEVELOPMENTAL CELL

Correlation of Sprouty1 and Jagged1 With Aggressive Prostate Cancer Cells With Different Sensitivities to Androgen Deprivation

(2014) Naoki Terada et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mathematical models of the transitions between endocrine therapy responsive and resistant states in breast cancer

(2014) C. Chen et al.   Journal of the Royal Society Interface

Towards elucidating the connection between epithelial-mesenchymal transitions and stemness

(2014) M. K. Jolly et al.   Journal of the Royal Society Interface

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition

(2014) L Jiang et al.   ONCOGENE

TGF- -induced epithelial-to-mesenchymal transition proceeds through stepwise activation of multiple feedback loops

(2014) J. Zhang et al.   Science Signaling

Targeting the epithelial to mesenchymal transition in glioblastoma: the emerging role of MET signaling

(2014) Do-Hyun Nam et al.   OncoTargets and Therapy

Targeting Mitochondrial Metabolism by Inhibiting Autophagy in BRAF-Driven Cancers

(2014) A. M. Strohecker et al.   Cancer Discovery

HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression

(2014) De Huang et al.   Cell Reports

A Mitochondrial Switch Promotes Tumor Metastasis

(2014) Paolo E. Porporato et al.   Cell Reports

Phenotypic Switch Induced by Simulated Microgravity on MDA-MB-231 Breast Cancer Cells

(2014) Maria Grazia Masiello et al.   Biomed Research International

The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation

(2013) Krithika Rajagopalan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Coupled Reversible and Irreversible Bistable Switches Underlying TGFβ-induced Epithelial to Mesenchymal Transition

(2013) Xiao-Jun Tian et al.   BIOPHYSICAL JOURNAL

A Switch in the Expression of Embryonic EMT-Inducers Drives the Development of Malignant Melanoma

(2013) Julie Caramel et al.   CANCER CELL

Tristability in Cancer-Associated MicroRNA-TF Chimera Toggle Switch

(2013) Mingyang Lu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The causes and consequences of genetic heterogeneity in cancer evolution

(2013) Rebecca A. Burrell et al.   NATURE

Biophysical regulation of epigenetic state and cell reprogramming

(2013) Timothy L. Downing et al.   NATURE MATERIALS

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Sub-Sets of Cancer Stem Cells Differ Intrinsically in Their Patterns of Oxygen Metabolism

(2013) Luke Gammon et al.   PLoS One

MicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determination

(2013) M. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

Hybrid T-Helper Cells: Stabilizing the Moderate Center in a Polarized System

(2013) Sui Huang   PLOS BIOLOGY

Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

(2012) Oscar H. Ocaña et al.   CANCER CELL

Epithelial-to-mesenchymal transition (EMT) confers primary resistance to trastuzumab (Herceptin)

(2012) Cristina Oliveras-Ferraros et al.   CELL CYCLE

Intrinsically disordered proteins and conformational noise

(2012) Gita Mahmoudabadi et al.   CELL CYCLE

Bistability, Bifurcations, and Waddington's Epigenetic Landscape

(2012) James E. Ferrell   CURRENT BIOLOGY

Lessons from tumor reversion for cancer treatment

(2012) Robert Amson et al.   CURRENT OPINION IN ONCOLOGY

Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells

(2012) Toni Celià-Terrassa et al.   JOURNAL OF CLINICAL INVESTIGATION

Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding

(2012) Cecilia Andresen et al.   NUCLEIC ACIDS RESEARCH

What makes the cell differentiate?

(2012) Andras Paldi   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Adaptive auto-regulation of androgen receptor provides a paradigm shifting rationale for bipolar androgen therapy (BAT) for castrate resistant human prostate cancer

(2012) John T. Isaacs et al.   PROSTATE

Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links

(2012) Christina Scheel et al.   SEMINARS IN CANCER BIOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The Cancer/Testis Antigen Prostate-associated Gene 4 (PAGE4) Is a Highly Intrinsically Disordered Protein

(2011) Yu Zeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein intrinsic disorder and induced pluripotent stem cells

(2011) Bin Xue et al.   Molecular BioSystems

Reciprocal repression between P53 and TCTP

(2011) Robert Amson et al.   NATURE MEDICINE

Beyond the Random Coil: Stochastic Conformational Switching in Intrinsically Disordered Proteins

(2011) Ucheor B. Choi et al.   STRUCTURE

Collective motions and specific effectors: a statistical mechanics perspective on biological regulation

(2010) Alessandro Giuliani   BMC GENOMICS

A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

(2010) Ronghui Li et al.   Cell Stem Cell

FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst

(2010) Y. Yamanaka et al.   DEVELOPMENT

Functional roles for noise in genetic circuits

(2010) Avigdor Eldar et al.   NATURE

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

(2010) A Singh et al.   ONCOGENE

Catalytic and chaperone-like functions in an intrinsically disordered protein associated with desiccation tolerance

(2010) S. Chakrabortee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding gene circuits at cell-fate branch points for rational cell reprogramming

(2010) Joseph X. Zhou et al.   TRENDS IN GENETICS

Oncogenes and Tumor Suppressor Genes

(2010) E. Y. H. P. Lee et al.   Cold Spring Harbor Perspectives in Biology

Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway

(2009) Z. Wang et al.   CANCER RESEARCH

Intrinsic Protein Disorder and Interaction Promiscuity Are Widely Associated with Dosage Sensitivity

(2009) Tanya Vavouri et al.   CELL

Disorder, Promiscuity, and Toxic Partnerships

(2009) Edward M. Marcotte et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Non-genetic heterogeneity of cells in development: more than just noise

(2009) S. Huang   DEVELOPMENT

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours

(2009) Amy Brock et al.   NATURE REVIEWS GENETICS

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Cancer attractors: A systems view of tumors from a gene network dynamics and developmental perspective

(2009) Sui Huang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

(2008) Arjun Raj et al.   CELL

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

Transcriptome-wide noise controls lineage choice in mammalian progenitor cells

(2008) Hannah H. Chang et al.   NATURE

Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

(2008) Anne-Pierre Morel et al.   PLoS One

Reprogramming stem cells is a microenvironmental task

(2008) M. J. Bissell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE