Remote C−H Functionalization of 8-Aminoquinolinamides

Copper-Catalyzed One-Pot N-Acylation and C5–H Halogenation of 8-Aminoquinolines: The Dual Role of Acyl Halides

(2018) Yi Du et al.   JOURNAL OF ORGANIC CHEMISTRY

Quinoline Fluorescent Probes for Zinc – from Diagnostic to Therapeutic Molecules in Treating Neurodegenerative Diseases

(2018) Barbara Czaplinska et al.   Medicinal Chemistry

C5-Regioselective C–H fluorination of 8-aminoquinoline amides and sulfonamides with Selectfluor under metal-free conditions

(2018) Yingchao Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Ruthenium(ii)-catalyzed remote C–H addition of 8 aminoquinoline amide to activated aldehyde

(2018) Susmita Mondal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Remote alkylation of N-(quinolin-8-yl)benzamides with alkyl bromides via ruthenium(ii)-catalyzed C–H bond activation

(2018) Arumugam Mariappan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A general method for the metal-free, regioselective, remote C–H halogenation of 8-substituted quinolines

(2018) Damoder Reddy Motati et al.   Chemical Science

Metal-Free C(sp3)–H Amination of 2-Oxindoles in Water: Facile Synthesis of 3-Substituted 3-Aminooxindoles

(2018) Wen-Ting Wei et al.   ACS Sustainable Chemistry & Engineering

Regioselective Chlorination of Aryl C−H bonds with Hypervalent Iodine(III) Reagent 1-Chloro-1,2-benziodoxol-3-one

(2018) Sai Prathima Parvathaneni et al.   Asian Journal of Organic Chemistry

TEMPO-Promoted C(sp3 )−H Hydroxylation of 2-Oxindoles at Room Temperature

(2018) Wen-Ming Zhu et al.   Asian Journal of Organic Chemistry

Selective remote C–H trifluoromethylation of aminoquinolines with CF3SO2Na under visible light irradiation in the absence of an external photocatalyst

(2018) Lulu Zhao et al.   Organic Chemistry Frontiers

A copper-catalyzed sulfonylative C–H bond functionalization from sulfur dioxide and aryldiazonium tetrafluoroborates

(2018) Hongguang Xia et al.   Organic Chemistry Frontiers

Ruthenium-Catalyzed Difluoroalkylation of 8-Aminoquinoline Amides at the C5-Position

(2017) Changpeng Chen et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

From Surprising Solvothermal Reaction to Uncommon Zinc(II)-Catalyzed Aromatic C–H Activation Reaction for Direct Nitroquinoline Synthesis

(2017) Yazhen Wang et al.   INORGANIC CHEMISTRY

Metal-free synthesis of isatin oximes via radical coupling reactions of oxindoles with t-BuONO in water

(2017) Wen-Ting Wei et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Selective remote esterification of 8-aminoquinoline amides via copper(ii)-catalyzed C(sp2)–O cross-coupling reaction

(2017) Chengcai Xia et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Visible-light-promoted selective C–H amination of heteroarenes with heteroaromatic amines under metal-free conditions

(2017) Supravat Samanta et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Combining Eosin Y with Selectfluor: A Regioselective Brominating System for Para-Bromination of Aniline Derivatives

(2017) Binbin Huang et al.   ORGANIC LETTERS

A Convenient Strategy for Remote C–H Bond Halogenation of 8-Aminoquinolines in the C5 Position

(2017) Meng Sun et al.   SYNLETT

Cobalt-Catalyzed Perfluoroalkylation of Quinoline Amides at the C5 Position

(2017) Jun-Long Niu et al.   SYNTHESIS-STUTTGART

The regioselective C5 halogenation of quinolines using sodium halides under transition metal-free conditions

(2017) Jun-Ying Jiao et al.   TETRAHEDRON

Copper-catalyzed remote C H ethoxycarbonyldifluoromethylation of 8-aminoquinolines with bis(pinacolato)diboron as reductant

(2017) Shuaijun Han et al.   TETRAHEDRON LETTERS

Iron-mediated remote C–H bond benzylation of 8-aminoquinoline amides

(2017) Mian Cui et al.   TETRAHEDRON LETTERS

Direct Reductive Quinolyl β-C–H Alkylation by Multispherical Cavity Carbon-Supported Cobalt Oxide Nanocatalysts

(2017) Feng Xie et al.   ACS Catalysis

Iodobenzene-catalyzed synthesis of aryl sulfonate esters from aminoquinolines via remote radical C–O cross-coupling

(2017) Chao Shen et al.   RSC Advances

Cobalt(ii)-catalyzed remote C5-selective C–H sulfonylation of quinolines via insertion of sulfur dioxide

(2017) Kai Wang et al.   RSC Advances

Metal-free C5-selective halogenation of quinolines under aqueous conditions

(2017) Jichao Chen et al.   Organic Chemistry Frontiers

Copper-catalyzed C5-selective thio/selenocyanation of 8-aminoquinolines

(2017) Jichao Chen et al.   Organic Chemistry Frontiers

Transition-metal-free direct perfluoroalkylation of quinoline amides at C5 position through radical cross-coupling under mild conditions

(2017) Jun Xu et al.   Organic Chemistry Frontiers

Merging photoredox catalysis with transition metal catalysis: site-selective C4 or C5-H phosphonation of 8-aminoquinoline amides

(2017) Huijie Qiao et al.   Organic Chemistry Frontiers

Copper(i) and N-fluorobenzenesulfonimide-mediated direct regioselective halogenation of 8-amidoquinolines on the C5 position

(2017) Xin He et al.   Organic Chemistry Frontiers

Nickel-catalyzed selective C-5 fluorination of 8-aminoquinolines with NFSI

(2017) Junshuai Ding et al.   Organic Chemistry Frontiers

Site-selective oxidative C–H sulfonylation of 8-acylaminoquinolines and anilides under metal-free conditions

(2017) Yang Wang et al.   Organic Chemistry Frontiers

Copper-Catalyzed Remote C−H Nitration of 8-Amidoquinolines

(2017) Bhuttu Khan et al.   ChemistrySelect

Metal-Free, Oxidant-Free, Site-Selective C−H Halogenations to Aminoquinolines at Room Temperature using N -Halosaccharins

(2017) Himangsu Sekhar Dutta et al.   ChemistrySelect

Copper(II)-Catalyzed and Chelation-Induced Remote C-H Halogenation of Quinolines under Neutral Conditions

(2017) Sheng Zhang et al.   ChemistrySelect

Regio-Selective C−H Halogenation of 8-Amido-Quinolines under Transition Metal Free Conditions

(2017) Chiranjit Sen et al.   ChemistrySelect

Copper-Catalyzed Remote C-H Sulfonylation of 8-Aminoquinoline Amides with Arylsulfonyl Hydrazides

(2017) Guoshu Chen et al.   ChemistrySelect

Copper-Catalyzed Remote C−H Functionalization of 8-Aminoquinolines with Sodium and Lithium Sulfinates

(2016) Shuai Liang et al.   ADVANCED SYNTHESIS & CATALYSIS

Copper-Catalyzed or -Mediated CH Bond Functionalizations Assisted by Bidentate Directing Groups

(2016) Jidan Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

A First Example of Cobalt-Catalyzed Remote CH Functionalization of 8-Aminoquinolines Operating through a Single Electron Transfer Mechanism

(2016) Christopher J. Whiteoak et al.   ADVANCED SYNTHESIS & CATALYSIS

Copper-Mediated Tandem C(sp2)-H Sulfenylation and Annulation of Arenes with 2-Mercaptoimidazoles: Regio- and Site-selective Access to Polycyclic Fused Imidazo[2,1-b][1,3]thiazinones

(2016) Jidan Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Directing Group-Assisted Copper(II)-Catalyzedortho-Carbonylation to Benzamide using 2,2′-Azobisisobutyronitrile (AIBN)

(2016) Bhuttu Khan et al.   ADVANCED SYNTHESIS & CATALYSIS

Copper-Catalyzed Remote C−H Amination of Quinolines withN-Fluorobenzenesulfonimide

(2016) Yao Yin et al.   ADVANCED SYNTHESIS & CATALYSIS

Nickel(II)-Mediated Regioselective CH Monoiodination of Arenes and Heteroarenes by using Molecular Iodine

(2016) Bhuttu Khan et al.   ADVANCED SYNTHESIS & CATALYSIS

Copper-Catalyzed 8-Amido Chelation-Induced Remote C−H Amination of Quinolines

(2016) Harekrishna Sahoo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Remote C−H Activation of Quinolines through Copper-Catalyzed Radical Cross-Coupling

(2016) Jun Xu et al.   Chemistry-An Asian Journal

Copper-Mediated Remote Highly Site-Selective C-H Bond Bromination and Chlorination of Quinolines at the C5 Position that is Geometrically Difficult to Access

(2016) Naidu Sambasiva Rao et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Remote C-H Selenylation of 8-Amidoquinolines via Copper-Catalyzed Radical Cross-Coupling

(2016) Harekrishna Sahoo et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed Regioselective C–H Sulfonylation of 8-Aminoquinolines

(2016) Jun Wei et al.   JOURNAL OF ORGANIC CHEMISTRY

4-Position-Selective C–H Perfluoroalkylation and Perfluoroarylation of Six-Membered Heteroaromatic Compounds

(2016) Masahiro Nagase et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A General Method for Aminoquinoline-Directed, Copper-Catalyzed sp2 C–H Bond Amination

(2016) James Roane et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transition-metal-free oxidative C5 C–H-halogenation of 8-aminoquinoline amides using sodium halides

(2016) Ying Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Copper(ii)-catalyzed C5 and C7 halogenation of quinolines using sodium halides under mild conditions

(2016) Jun Xu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

5-Position-selective C–H trifluoromethylation of 8-aminoquinoline derivatives

(2016) Yoichiro Kuninobu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Metal-Free Remote C–H Bond Amidation of 8-Amidoquinolines on the C5 Position under Mild Conditions

(2016) Dezhong Ji et al.   ORGANIC LETTERS

Nickel-Catalyzed Site-Selective C–H Bond Difluoroalkylation of 8-Aminoquinolines on the C5-Position

(2016) Hao Chen et al.   ORGANIC LETTERS

Rh-Catalyzed, Regioselective, C–H Bond Functionalization: Access to Quinoline-Branched Amines and Dimers

(2016) M. Damoder Reddy et al.   ORGANIC LETTERS

Regio- and Chemoselective Mono- and Bisnitration of 8-Amino quinoline Amides with Fe(NO3)3·9H2O as Promoter and Nitro Source

(2016) Yan He et al.   ORGANIC LETTERS

Copper-Catalyzed Regioselective C–H Iodination of Aromatic Carboxamides

(2016) Qiaolin Wu et al.   SYNLETT

Copper-catalyzed C5-regioselective C H sulfonylation of 8-aminoquinoline amides with aryl sulfonyl chlorides

(2016) Jun-Ming Li et al.   TETRAHEDRON LETTERS

Copper-catalyzed rapid C–H nitration of 8-aminoquinolines by using sodium nitrite as the nitro source under mild conditions

(2016) Xiaolei Zhu et al.   RSC Advances

A simple quinoline-derived fluorescent sensor for the selective and sequential detection of copper(ii) and sulfide ions and its application in living-cell imaging

(2016) Haiyang Liu et al.   RSC Advances

PhI(OAc)2 oxidative C5 halogenation of quinolines using copper halides under mild conditions

(2016) Xing-Xing Liu et al.   RSC Advances

Copper(ii)-catalyzed remote sulfonylation of aminoquinolines with sodium sulfinates via radical coupling

(2016) Chengcai Xia et al.   RSC Advances

Metal-Free Oxidative C−H Amination of 8-Acylaminoquinolines and Anilides with N -Fluorobenzenesulfonimide

(2016) Yang Wang et al.   Asian Journal of Organic Chemistry

Oxidative Remote C−H Trifluoromethylation of Quinolineamides on the C5 Position with Iodobenzene Diacetate as the Oxidizing Agent

(2016) Zhaoyang Wu et al.   Asian Journal of Organic Chemistry

Silver(i)-promoted C5–H phosphonation of 8-aminoquinoline amides with H-phosphonates

(2016) Mengmeng Sun et al.   Organic Chemistry Frontiers

Copper-catalyzed 8-amido chelation-induced regioselective C–H fluoroalkylation of quinolines

(2016) Li-Kun Jin et al.   Organic Chemistry Frontiers

Functionalization of Quinolines through Copper-Catalyzed Regioselective Halogenation Reaction

(2016) Harekrishna Sahoo et al.   ChemistrySelect

The Highly Regioselective Halogenation of N-(8-quinolinyl)amides on the C-5 Position with Cuprous Halides Under Mild Conditions

(2016) Junshuai Ding et al.   ChemistrySelect

Distant C-H Activation/Functionalization: A New Horizon of Selectivity Beyond Proximity

(2015) Ritika Sharma et al.   CATALYSIS REVIEWS-SCIENCE AND ENGINEERING

Selective remote C–H sulfonylation of aminoquinolines with arylsulfonyl chlorides via copper catalysis

(2015) Hong-Wen Liang et al.   CHEMICAL COMMUNICATIONS

Metal-free synthesis of N-fused heterocyclic iodides via C–H functionalization mediated by tert-butylhydroperoxide

(2015) Krishna K. Sharma et al.   CHEMICAL COMMUNICATIONS

The regioselective iodination of quinolines, quinolones, pyridones, pyridines and uracil

(2015) Uttam Dutta et al.   CHEMICAL COMMUNICATIONS

Pioneering Metal-Free Oxidative Coupling Strategy of Aromatic Compounds Using Hypervalent Iodine Reagents

(2015) Yasuyuki Kita et al.   CHEMICAL RECORD

β-d-2′-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5′-Triphosphate Forms

(2015) Longhu Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ligand-enabled meta-C–H activation using a transient mediator

(2015) Xiao-Chen Wang et al.   NATURE

Nickel-catalyzed synthesis of diarylsulfides and sulfones via C–H bond functionalization of arylamides

(2015) Vutukuri Prakash Reddy et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Regioselective, Molecular Iodine-Mediated C3 Iodination of Quinolines

(2015) Kai Sun et al.   ORGANIC LETTERS

Copper-Mediated Remote C–H Bond Chalcogenation of Quinolines on the C5 Position

(2015) Longzhi Zhu et al.   ORGANIC LETTERS

Copper(I)-Catalyzed Sulfonylation of 8-Aminoquinoline Amides with Sulfonyl Chlorides in Air

(2015) Huijie Qiao et al.   ORGANIC LETTERS

Hypervalent Iodine(III) in Direct Carbon–Hydrogen Bond Functionalization

(2015) Andrey Antonchick et al.   SYNLETT

Copper and palladium mediated C–H chlorination on 8-acylaminoquinoline scaffolds

(2015) Haili Guo et al.   TETRAHEDRON

Recent advances in the C–H-functionalization of the distal positions in pyridines and quinolines

(2015) David E. Stephens et al.   TETRAHEDRON

Transition-Metal-Catalyzed Site-Selective C–H Functionalization of Quinolines beyond C2 Selectivity

(2015) Tomohiro Iwai et al.   ACS Catalysis

Copper-catalyzed C–H alkylation of 8-aminoquinolines via 8-amide chelation assistance

(2015) Xiao-Feng Xia et al.   RSC Advances

Directing Remote Meta-C–H Functionalization with Cleavable Auxiliaries

(2015) Christopher G. Frost et al.   ACS Central Science

Cobalt-Catalyzed C-4 Selective Alkylation of Quinolines

(2014) Shohei Yamamoto et al.   ADVANCED SYNTHESIS & CATALYSIS

Discovery of quinoline small molecules with potent dispersal activity against methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a scaffold hopping strategy

(2014) Yasmeen Abouelhassan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Coordination of Hydroxyquinolines to a Ruthenium Bis-dimethyl-phenanthroline Scaffold Radically Improves Potency for Potential as Antineoplastic Agents

(2014) David K. Heidary et al.   JOURNAL OF MEDICINAL CHEMISTRY

Iron-Catalyzed, Chelation-Induced Remote C–H Allylation of Quinolines via 8-Amido Assistance

(2014) Xuefeng Cong et al.   ORGANIC LETTERS

Copper-Mediated Tandem Oxidative C(sp2)–H/C(sp)–H Alkynylation and Annulation of Arenes with Terminal Alkynes

(2014) Jiaxing Dong et al.   ORGANIC LETTERS

Directed Amination of Non-Acidic Arene CH Bonds by a Copper-Silver Catalytic System

(2013) Ly Dieu Tran et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

8-Aminoquinoline: A Powerful Directing Group in Metal-Catalyzed Direct Functionalization of CH Bonds

(2013) Matthieu Corbet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Mediated CH/CH Biaryl Coupling of Benzoic Acid Derivatives and 1,3-Azoles

(2013) Mayuko Nishino et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The antitumor activity of zinc(II) and copper(II) complexes with 5,7-dihalo-substituted-8-quinolinoline

(2013) Yan-Cheng Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Copper-Catalyzed, Directing Group-Assisted Fluorination of Arene and Heteroarene C–H Bonds

(2013) Thanh Truong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Divergence between Organometallic and Single-Electron-Transfer Mechanisms in Copper(II)-Mediated Aerobic C–H Oxidation

(2013) Alison M. Suess et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhodium(III)-Catalyzed Oxidative Olefination of Pyridines and Quinolines: Multigram-Scale Synthesis of Naphthyridinones

(2013) Jun Zhou et al.   ORGANIC LETTERS

Copper-Catalyzed Etherification of Arene C–H Bonds

(2013) James Roane et al.   ORGANIC LETTERS

Palladium-Catalyzed C-2 Selective Arylation of Quinolines

(2013) Xiaoyu Ren et al.   ORGANIC LETTERS

Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA–Cap Interaction

(2012) Xiaoqi Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Copper-Dependent Cytotoxicity of 8-Hydroxyquinoline Derivatives Correlates with Their Hydrophobicity and Does Not Require Caspase Activation

(2012) Saverio Tardito et al.   JOURNAL OF MEDICINAL CHEMISTRY

Copper-Promoted Sulfenylation of sp2 C–H Bonds

(2012) Ly Dieu Tran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Substituted oxines inhibit endothelial cell proliferation and angiogenesis

(2012) Shridhar Bhat et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Ammosamide D, an Oxidatively Ring Opened Ammosamide Analog from a Marine-Derived Streptomyces variabilis

(2012) Ende Pan et al.   ORGANIC LETTERS

Effect of Postflood Quinclorac Applications on Commercial Rice Cultivars

(2012) Jason A. Bond et al.   WEED TECHNOLOGY

Pd0/PR3-Catalyzed Arylation of Nicotinic and Isonicotinic Acid Derivatives

(2010) Masayuki Wasa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct C−H Arylation of Electron-Deficient Heterocycles with Arylboronic Acids

(2010) Ian B. Seiple et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ir-catalyzed highly selective addition of pyridyl C–H bonds to aldehydes promoted by triethylsilane

(2010) Bi-Jie Li et al.   Chemical Science

Copper-Catalyzed Direct C Arylation of Heterocycles with Aryl Bromides: Discovery of Fluorescent Core Frameworks

(2009) Dongbing Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel-Catalyzed Reaction of Arylzinc Reagents with N-Aromatic Heterocycles: A Straightforward Approach to C−H Bond Arylation of Electron-Deficient Heteroaromatic Compounds

(2009) Mamoru Tobisu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sc(OTf)3-Catalyzed Direct Alkylation of Quinolines and Pyridines with Alkanes

(2009) Guojun Deng et al.   ORGANIC LETTERS

Hypervalent iodine(III): selective and efficient single-electron-transfer (SET) oxidizing agent

(2009) Toshifumi Dohi et al.   TETRAHEDRON

Ammosamides A and B Target Myosin

(2008) Chambers C. Hughes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Ammosamides: Structures of Cell Cycle Modulators from a Marine-DerivedStreptomycesSpecies

(2008) Chambers C. Hughes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rh(I)-Catalyzed Direct Arylation of Pyridines and Quinolines

(2008) Ashley M. Berman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ammosamides A and B new cytotoxic alkaloids isolated from a marine Streptomyces sp

(2008) SP Gaudêncio et al.   PLANTA MEDICA

Quinoline, quinazoline and acridonealkaloids

(2007) Joseph P. Michael   NATURAL PRODUCT REPORTS