4.4 Article

Copper-Catalyzed Remote C - H Nitration of 8-Amidoquinolines

Journal

CHEMISTRYSELECT
Volume 2, Issue 1, Pages 260-264

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201601917

Keywords

copper; nitration; quinoline; remote C-H; functionalization; tert-butyl nitrite

Funding

  1. CSIR network project [BSC-0120]
  2. UGC-New Delhi

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A highly efficient copper catalyzed remote C - H nitration of 8-amidoquinolines has been developed using tert-butyl nitrite as nitrating agent. 5 mol% of catalyst under room temperature furnished the products in excellent yields for arene, heteroarene, aliphatic carboxamide derivatives.

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