Significance of prohibitin domain family in tumorigenesis and its implication in cancer diagnosis and treatment

The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax

(2017) Ana M. Cosialls et al.   HAEMATOLOGICA

Neuronal expression of the mitochondrial protein prohibitin confers profound neuroprotection in a mouse model of focal cerebral ischemia

(2017) Anja Kahl et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Low Levels of Prohibitin in Substantia Nigra Makes Dopaminergic Neurons Vulnerable in Parkinson’s Disease

(2017) Debashis Dutta et al.   MOLECULAR NEUROBIOLOGY

Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours

(2017) H Yurugi et al.   ONCOGENE

Transcriptional and Post-Transcriptional Mechanisms of the Development of Neocortical Lamination

(2017) Tatiana Popovitchenko et al.   Frontiers in Neuroanatomy

Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics

(2017) Tetsuro Yoshimaru et al.   Scientific Reports

The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax

(2017) Ana M. Cosialls et al.   HAEMATOLOGICA

Post-transcriptional Regulation of Genes Related to Biological Behaviors of Gastric Cancer by Long Noncoding RNAs and MicroRNAs

(2017) Wenjing Liu et al.   Journal of Cancer

The prohibitin-repressive interaction with E2F1 is rapidly inhibited by androgen signalling in prostate cancer cells

(2017) S Koushyar et al.   Oncogenesis

Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer’s disease progression

(2017) Mercedes Lachén-Montes et al.   Scientific Reports

Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier

(2016) Christina Ising et al.   AMERICAN JOURNAL OF PATHOLOGY

Finally, An Apoptosis-Targeting Therapeutic for Cancer

(2016) C. M. Croce et al.   CANCER RESEARCH

Skp2 is over-expressed in breast cancer and promotes breast cancer cell proliferation

(2016) Wenwen Zhang et al.   CELL CYCLE

Prohibitin involvement in the generation of mitochondrial superoxide at complex I in human sperm

(2016) Ran-Ran Chai et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Prohibitin overexpression predicts poor prognosis and promotes cell proliferation and invasion through ERK pathway activation in gallbladder cancer

(2016) Yang Cao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Metastatic colonization by circulating tumour cells

(2016) Joan Massagué et al.   NATURE

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Inhibition of the CRAF/prohibitin interaction reverses CRAF-dependent resistance to vemurafenib

(2016) N A Doudican et al.   ONCOGENE

Metastasis as an evolutionary process

(2016) S. Turajlic et al.   SCIENCE

Identification of novel biomarkers associated with poor patient outcomes in invasive breast carcinoma

(2016) Renata A. Canevari et al.   TUMOR BIOLOGY

Adriamycin resistance-associated prohibitin gene inhibits proliferation of human osteosarcoma MG63 cells by interacting with oncogenes and tumor suppressor genes

(2016) Min-Dong Du et al.   Oncology Letters

Multifaceted role of prohibitin in cell survival and apoptosis

(2015) Ya-Ting Peng et al.   APOPTOSIS

The stromal cell-surface protease fibroblast activation protein-α localizes to lipid rafts and is recruited to invadopodia

(2015) Julia D. Knopf et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

Unveiling the potential of prohibitin in cancer

(2015) Sarah Koushyar et al.   CANCER LETTERS

Mapping the Pathways of Resistance to Targeted Therapies

(2015) K. C. Wood   CANCER RESEARCH

The Stress Kinase p38  as a Target for Cancer Therapy

(2015) A. Igea et al.   CANCER RESEARCH

Therapeutic advances in BIG3-PHB2 inhibition targeting the crosstalk between estrogen and growth factors in breast cancer

(2015) Tetsuro Yoshimaru et al.   CANCER SCIENCE

Alike but Different: RAF Paralogs and Their Signaling Outputs

(2015) Enrico Desideri et al.   CELL

Prohibitin (PHB) roles in granulosa cell physiology

(2015) Indrajit Chowdhury et al.   CELL AND TISSUE RESEARCH

Prohibitin 2: At a communications crossroads

(2015) Alberto Bavelloni et al.   IUBMB LIFE

Function and information content of DNA methylation

(2015) Dirk Schübeler   NATURE

A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation

(2015) Cristina Moncunill-Massaguer et al.   Oncotarget

Emerging role of microRNA-27a in human malignant glioma cell survival via targeting of prohibitin

(2015) WEI CHEN et al.   Molecular Medicine Reports

BIG3 Inhibits the Estrogen-Dependent Nuclear Translocation of PHB2 via Multiple Karyopherin-Alpha Proteins in Breast Cancer Cells

(2015) Nam-Hee Kim et al.   PLoS One

A Trifluorinated Thiazoline Scaffold Leading to Pro-apoptotic Agents Targeting Prohibitins

(2014) Alba Pérez-Perarnau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of prohibitin and prohibiton as novel factors binding to the p53 induced gene 3 (PIG3) promoter (TGYCC)15 motif

(2014) Xiaoxiang Guan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prohibitin is involved in the activated internalization and degradation of protease-activated receptor 1

(2014) Yan-Jie Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells

(2014) Lakshmi Reddy Bollu et al.   CELL CYCLE

Prohibitin 2 represents a novel nuclear AKT substrate during all-trans retinoic acid–induced differentiation of acute promyelocytic leukemia cells

(2014) Alberto Bavelloni et al.   FASEB JOURNAL

The aberrant expression and localization of prohibitin during apoptosis of human cholangiocarcinoma Mz-ChA-1 cells

(2014) Wei Song et al.   FEBS LETTERS

Differential expression and regulation of prohibitin during curcumin-induced apoptosis of immortalized human epidermal HaCaT cells

(2014) HAI-BO YANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Virulence Polysaccharide Vi Released by Salmonella Typhi Targets Membrane Prohibitin to Inhibit T-Cell Activation

(2014) Srikanth K. Santhanam et al.   JOURNAL OF INFECTIOUS DISEASES

Targeting the prohibitin scaffold-CRAF kinase interaction in RAS-ERK-driven pancreatic ductal adenocarcinoma

(2014) Zhou Luan et al.   Molecular Cancer

Mechanism-based cancer therapy: resistance to therapy, therapy for resistance

(2014) P Ramos et al.   ONCOGENE

Prohibitin Expression Deregulation in Gastric Cancer Is Associated with the 3′ Untranslated Region 1630 C>T Polymorphism and Copy Number Variation

(2014) Mariana Ferreira Leal et al.   PLoS One

Metabolic control of cell death

(2014) D. R. Green et al.   SCIENCE

Identification of prohibitin 1 as a potential prognostic biomarker in human pancreatic carcinoma using modified aqueous two-phase partition system combined with 2D-MALDI-TOF-TOF-MS/MS

(2014) Ning Zhong et al.   TUMOR BIOLOGY

Prohibitin Induces Apoptosis in BGC823 Gastric Cancer Cells Through the Mitochondrial Pathway

(2013) Long Zhang et al.   Asian Pacific Journal of Cancer Prevention

Increase in Neuroexcitability of Unmyelinated C-type Vagal Ganglion Neurons During Initial Postnatal Development of Visceral Afferent Reflex Functions

(2013) Zhao Qian et al.   CNS Neuroscience & Therapeutics

The Presence of HIV-1 Tat Protein Second Exon Delays Fas Protein-mediated Apoptosis in CD4+T Lymphocytes

(2013) María Rosa López-Huertas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prohibitin-2 Binding Modulates Insulin-like Growth Factor-binding Protein-6 (IGFBP-6)-induced Rhabdomyosarcoma Cell Migration

(2013) Ping Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling pathways of prohibitin and its role in diseases

(2013) Tian-Biao Zhou et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Polymorphisms in the p27kip-1 and prohibitin genes denote novel genes associated with melanoma risk in Brazil, a high ultraviolet index region

(2013) Guilherme Francisco et al.   MELANOMA RESEARCH

Prohibitin-2 promotes hepatocellular carcinoma malignancy progression in hypoxia based on a label-free quantitative proteomics strategy

(2013) Jun Cheng et al.   MOLECULAR CARCINOGENESIS

The quest to overcome resistance to EGFR-targeted therapies in cancer

(2013) Curtis R Chong et al.   NATURE MEDICINE

Mechanisms of resistance to therapies targeting BRCA-mutant cancers

(2013) Christopher J Lord et al.   NATURE MEDICINE

Prohibitin is required for transcriptional repression by the WT1–BASP1 complex

(2013) E Toska et al.   ONCOGENE

Induction of Paclitaxel Resistance by ERα Mediated Prohibitin Mitochondrial-Nuclear Shuttling

(2013) Pei Dong et al.   PLoS One

Targeting BIG3–PHB2 interaction to overcome tamoxifen resistance in breast cancer cells

(2013) Tetsuro Yoshimaru et al.   Nature Communications

Expression of prohibitins on the surface of activated T cells

(2012) Hajime Yurugi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Recombinant viral capsid protein VP1 suppresses migration and invasion of human cervical cancer by modulating phosphorylated prohibitin in lipid rafts

(2012) Ching-Feng Chiu et al.   CANCER LETTERS

Targeting of a Conformationally Exposed, Tumor-Specific Epitope of EGFR as a Strategy for Cancer Therapy

(2012) H. K. Gan et al.   CANCER RESEARCH

The Natural Anticancer Compounds Rocaglamides Inhibit the Raf-MEK-ERK Pathway by Targeting Prohibitin 1 and 2

(2012) Gernot Polier et al.   CHEMISTRY & BIOLOGY

Prohibitin is an important biomarker for nasopharyngeal carcinoma progression and prognosis

(2012) Qianjin Liao et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Androgen-regulated processing of the oncomir MiR-27a, which targets Prohibitin in prostate cancer

(2012) Claire E. Fletcher et al.   HUMAN MOLECULAR GENETICS

Identification of prohibitin as a Chikungunya virus receptor protein

(2012) Phitchayapak Wintachai et al.   JOURNAL OF MEDICAL VIROLOGY

Prohibitin Reduces Mitochondrial Free Radical Production and Protects Brain Cells from Different Injury Modalities

(2012) P. Zhou et al.   JOURNAL OF NEUROSCIENCE

Identification of Human Host Proteins Contributing to H5N1 Influenza Virus Propagation by Membrane Proteomics

(2012) Cheng Liu et al.   JOURNAL OF PROTEOME RESEARCH

Lentiviral vector-mediated RNA interference targeted against prohibitin inhibits apoptosis of the retinoic acid-resistant acute promyelocytic leukemia cell line NB4-R1

(2012) YANFENG LIU et al.   Molecular Medicine Reports

Raf activation by Ras and promotion of cellular metastasis require phosphorylation of prohibitin in the raft domain of the plasma membrane

(2012) C-F Chiu et al.   ONCOGENE

Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration

(2012) Carsten Merkwirth et al.   PLoS Genetics

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

Prohibitins are involved in protease-activated receptor 1-mediated platelet aggregation

(2011) Y. ZHANG et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Nucleolar proteins with altered expression in leukemic cell lines

(2011) Kaisa J. Teittinen et al.   LEUKEMIA RESEARCH

Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28

(2011) Pooi-Fong Wong et al.   PHYTOMEDICINE

Dengue-2-virus-interacting polypeptides involved in mosquito cell infection

(2010) Mandar S. Paingankar et al.   ARCHIVES OF VIROLOGY

Localization of Prohibitin in the Nuclear Matrix and Alteration of Its Expression During Differentiation of Human Neuroblastoma SK-N-SH Cells Induced by Retinoic Acid

(2010) Qi-Fu Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Prohibitin is a cholesterol-sensitive regulator of cell cycle transit

(2010) Pei Dong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Small RNAs are on the move

(2010) Daniel H. Chitwood et al.   NATURE

Mitochondrial comparative proteomics of human ovarian cancer cells and their platinum-resistant sublines

(2010) Zhiqin Dai et al.   PROTEOMICS

Relationship between urinary sodium excretion and pioglitazone-induced edema

(2010) Akinobu Nakamura et al.   Journal of Diabetes Investigation

Proteomic identification of anti-cancer proteins in luteolin-treated human hepatoma Huh-7 cells

(2009) Dong Ryeol Yoo et al.   CANCER LETTERS

Principles of ubiquitin and SUMO modifications in DNA repair

(2009) Steven Bergink et al.   NATURE

The promises and pitfalls of RNA-interference-based therapeutics

(2009) Daniela Castanotto et al.   NATURE

Interaction between O-GlcNAc Modification and Tyrosine Phosphorylation of Prohibitin: Implication for a Novel Binary Switch

(2009) Sudharsana R. Ande et al.   PLoS One

Prohibitin and mitochondrial biology

(2009) Marta Artal-Sanz et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus

(2008) Chikanori Kuramori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin

(2008) Tao Liu et al.   CANCER LETTERS

Quality control of mitochondria: protection against neurodegeneration and ageing

(2008) Takashi Tatsuta et al.   EMBO JOURNAL

Positional and expressive alteration of prohibitin during the induced differentiation of human hepatocarcinoma SMMC-7721 cells

(2008) Dong-Hui Xu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

A Repressive Role for Prohibitin in Estrogen Signaling

(2007) Bin He et al.   MOLECULAR ENDOCRINOLOGY

A structure for the yeast prohibitin complex: Structure prediction and evidence from chemical crosslinking and mass spectrometry

(2002) Jaap W. Back et al.   PROTEIN SCIENCE