Journal
JOURNAL OF CANCER
Volume 8, Issue 19, Pages 4141-4154Publisher
IVYSPRING INT PUBL
DOI: 10.7150/jca.22076
Keywords
ncRNAs; lncRNAs; miRNAs; gastric cancer; post-transcriptional regulation
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Funding
- National Science and Technology Support Program [2015BAI13B07]
- National Natural Science Foundation [81772987]
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Noncoding RNAs play critical roles in regulating protein-coding genes and comprise two major classes: long noncoding RNAs (lncRNAs) and microRNAs (miRNAs). LncRNAs regulate gene expression at transcriptional, post-transcriptional, and epigenetic levels via multiple action modes. LncRNAs can also function as endogenous competitive RNAs for miRNAs and indirectly regulate gene expression post-transcriptionally. By binding to the 3'-untranslated regions (3'-UTR) of target genes, miRNAs post-transcriptionally regulate gene expression. Herein, we conducted a review of post-transcriptional regulation by lncRNAs and miRNAs of genes associated with biological behaviors of gastric cancer.
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