Prohibitin overexpression predicts poor prognosis and promotes cell proliferation and invasion through ERK pathway activation in gallbladder cancer

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Fibronectin promotes cell proliferation and invasion through mTOR signaling pathway activation in gallbladder cancer

(2015) Yang Cao et al.   CANCER LETTERS

HOXD9 promotes epithelial–mesenchymal transition and cancer metastasis by ZEB1 regulation in hepatocellular carcinoma

(2015) Xiupeng Lv et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallbladder cancer cells by activating the PI3K/AKT pathway

(2015) Yi-Jun Shu et al.   Molecular Cancer

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

(2015) Luping Lin et al.   NATURE GENETICS

MALAT1 promotes the proliferation and metastasis of gallbladder cancer cells by activating the ERK/MAPK pathway

(2014) Xiang-Song Wu et al.   CANCER BIOLOGY & THERAPY

Yes-associated protein 1 (YAP1) promotes human gallbladder tumor growth via activation of the AXL/MAPK pathway

(2014) Maolan Li et al.   CANCER LETTERS

KRAS mutations in tumor tissue and plasma by different assays predict survival of patients with metastatic colorectal cancer

(2014) Jian-Ming Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Antitumor activity of selective MEK1/2 inhibitor AZD6244 in combination with PI3K/mTOR inhibitor BEZ235 in gefitinib-resistant NSCLC xenograft models

(2014) Yiqing Qu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting the prohibitin scaffold-CRAF kinase interaction in RAS-ERK-driven pancreatic ductal adenocarcinoma

(2014) Zhou Luan et al.   Molecular Cancer

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

(2014) Chong Sun et al.   NATURE

Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway

(2014) Maolan Li et al.   NATURE GENETICS

Evaluation of Two Inflammation-Based Prognostic Scores in Patients with Resectable Gallbladder Carcinoma

(2013) Xiang-Song Wu et al.   ANNALS OF SURGICAL ONCOLOGY

Prohibitin-2 promotes hepatocellular carcinoma malignancy progression in hypoxia based on a label-free quantitative proteomics strategy

(2013) Jun Cheng et al.   MOLECULAR CARCINOGENESIS

IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase–driven tumors

(2013) Katherine L Jameson et al.   NATURE MEDICINE

The Natural Anticancer Compounds Rocaglamides Inhibit the Raf-MEK-ERK Pathway by Targeting Prohibitin 1 and 2

(2012) Gernot Polier et al.   CHEMISTRY & BIOLOGY

Prohibitin in squamous cell carcinoma of the lung: its expression and possible clinical significance

(2012) Feng Guo et al.   HUMAN PATHOLOGY

Raf activation by Ras and promotion of cellular metastasis require phosphorylation of prohibitin in the raft domain of the plasma membrane

(2012) C-F Chiu et al.   ONCOGENE

Gallbladder cancer: Past, present and an uncertain future

(2012) C. Boutros et al.   SURGICAL ONCOLOGY-OXFORD

Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice

(2010) Kwang Suk Ko et al.   HEPATOLOGY

Unusual Thermal Disassembly of the SPFH Domain Oligomer from Pyrococcus horikoshii

(2009) Yohta Kuwahara et al.   BIOPHYSICAL JOURNAL

Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations

(2009) Qinglong Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Prohibitin Is Overexpressed in Papillary Thyroid Carcinomas Bearing the BRAFV600E Mutation

(2009) Alessandra Franzoni et al.   THYROID

Gallbladder cancer

(2008) Stavros Gourgiotis et al.   AMERICAN JOURNAL OF SURGERY

A structure for the yeast prohibitin complex: Structure prediction and evidence from chemical crosslinking and mass spectrometry

(2002) Jaap W. Back et al.   PROTEIN SCIENCE