Journal
CANCER RESEARCH
Volume 75, Issue 20, Pages 4247-4251Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-15-1248
Keywords
-
Categories
Funding
- NIH Building Interdisciplinary Research Careers in Women's Health Program
- Harry J. Lloyd Trust
- Golfers Against Cancer
- Stewart Trust
- V Foundation for Cancer Research
- Ovarian Cancer Research Fund
- Duke University School of Medicine
- Duke Cancer Institute
Ask authors/readers for more resources
Resistance substantially limits the depth and duration of clinical responses to targeted anticancer therapies. Through the use of complementary experimental approaches, investigators have revealed that cancer cells can achieve resistance through adaptation or selection driven by specific genetic, epigenetic, or micro-environmental alterations. Ultimately, these diverse alterations often lead to the activation of signaling pathways that, when co-opted, enable cancer cells to survive drug treatments. Recently developed methods enable the direct and scalable identification of the signaling pathways capable of driving resistance in specific contexts. Using these methods, novel pathways of resistance to clinically approved drugs have been identified and validated. By combining systematic resistance pathway mapping methods with studies revealing biomarkers of specific resistance pathways and pharmacologic approaches to block these pathways, it may be possible to rationally construct drug combinations that yield more penetrant and lasting responses in patients. (C) 2015 AACR.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available