Journal
CELL AND TISSUE RESEARCH
Volume 363, Issue 1, Pages 19-29Publisher
SPRINGER
DOI: 10.1007/s00441-015-2302-9
Keywords
Prohibitin (PHB); Granulosa cells (GCs); Differentiation; Survival; Mitochondria
Categories
Funding
- National Institutes of Health [1RO1HD057235, HD41749, 1SC3GM113751, U54-CA118638, G12-RR03034]
- NIH/NCRR [C06RR18386]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R01HD057235] Funding Source: NIH RePORTER
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [U54HD041749] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [U54CA118638] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [C06RR018386, G12RR003034] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [SC3GM113751] Funding Source: NIH RePORTER
- National Institute on Minority Health and Health Disparities [S21MD000101] Funding Source: NIH RePORTER
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Ovarian granulosa cells (GC) play an important role in the growth and development of the follicle in the process known as folliculogenesis. In the present review, we focus on recent developments in prohibitin (PHB) research in relation to GC physiological functions. PHB is a member of a highly conserved eukaryotic protein family containing the repressor of estrogen activity (REA)/stomatin/PHB/flotillin/HflK/C (SPFH) domain (also known as the PHB domain) found in diverse species from prokaryotes to eukaryotes. PHB is ubiquitously expressed in a circulating free form or is present in multiple cellular compartments including mitochondria, nucleus and plasma membrane. In mitochondria, PHB is anchored to the mitochondrial inner membrane and forms complexes with the ATPases associated with proteases having diverse cellular activities. PHB continuously shuttles between the mitochondria, cytosol and nucleus. In the nucleus, PHB interacts with various transcription factors and modulates transcriptional activity directly or through interactions with chromatin remodeling proteins. Many functions have been attributed to the mitochondrial and nuclear PHB complexes such as cellular differentiation, anti-proliferation, morphogenesis and maintenance of the functional integrity of the mitochondria. However, to date, the regulation of PHB expression patterns and GC physiological functions are not completely understood.
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