Article
Biochemistry & Molecular Biology
Wei Song, Yuan-Jing Ren, Lu-Lu Liu, Ya-Ying Zhao, Qi-Fu Li, Hai-Bo Yang
Summary: The study revealed that curcumin induces apoptosis in HaCaT cells through both caspase-dependent and caspase-independent pathways, providing potential evidence for treating proliferative skin diseases, including skin cancer.
Article
Multidisciplinary Sciences
Geetika Bassi, Suresh Mishra
Summary: Mitochondria play a crucial role in steroidogenesis, particularly in cholesterol transport and P450scc enzyme synthesis. A study on transgenic mice reveals that PHB1 has a regulatory role in Leydig cell steroidogenesis, involving cell signaling, cholesterol homeostasis, and mitochondrial biology.
Article
Cell Biology
Jiadong Zheng, Yifan Guo, Changyi Shi, Shuai Yang, Wenyan Xu, Xianjue Ma
Summary: This study reveals the important role of Ire1 in cell competition, regulating the fate of loser cells through controlling apoptosis and autophagy, and provides molecular insights into scrib-mediated TSCC.
Article
Multidisciplinary Sciences
Hyeon-Jin Kim, Greg Booth, Lauren Saunders, Sanjay Srivatsan, Jose L. McFaline-Figueroa, Cole Trapnell
Summary: This article describes a simple and cost-effective method for normalizing transcript counts and reducing technical variability in single-cell RNA sequencing. By using a mixture of DNA standards, the authors improve the detection of global transcriptome changes.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Shaowei Mao, Di Zhang, Luan Chen, Jie Tan, Yunpeng Chu, Sijia Huang, Wenqi Zhou, Hengwei Qin, Qinghua Xia, Yueran Zhao, Rongxiu Li, Shengying Qin, Muyun Wei
Summary: Metastasis is a serious risk for RCC patients and understanding the molecular mechanisms underlying it is crucial for developing new therapeutic approaches. Studies have shown that FKBP51 may play a role in regulating ECM function and promoting invasion and migration of tumor cells in RCC. The study found that FKBP51 promotes ccRCC invasion and migration by binding with TIMP3, connecting it with Beclin1 complex and increasing autophagic degradation of TIMP3.
CELL DEATH & DISEASE
(2021)
Article
Biophysics
Rachel K. Heussner, Hongrong Zhang, Guhan Qian, Mikayla J. Baker, Paolo P. Provenzano
Summary: Cancer stem cells (CSCs) show enhanced motility compared to well-differentiated carcinoma cells in various environments. CSCs exhibit a twofold increase in motility across different platforms, suggesting a general shift in cell migration mechanics. The source of differences in migration is attributed to the contractility of CSCs and the development of focal adhesions, which can be manipulated to tune CSC migration.
BIOPHYSICAL JOURNAL
(2023)
Article
Immunology
Mahmoud Moawad, Ghada M. Nasr, Afaf S. Osman, Emad S. Shaker
Summary: This study investigated the effects of curcumin nanoparticles and nanocapsules on the expression of p53, Bcl-2, Bax, and Caspase-3 genes in a liver cancer cell line. Results showed that curcumin nanocapsules increased the population of apoptotic cells and upregulated proapoptotic genes while decreasing the Bcl-2/Bax ratio.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2023)
Article
Microbiology
Kazunori Matsumura, Satoshi Takaki, Teruo Kirikae
Summary: PE_PGRS30 is a member of the PE_PGRS protein family, characterized by a conserved Pro-Glu (PE) domain and a typically polymorphic GC-rich sequence (PGRS) domain. It acts as a virulence factor of Mycobacterium tuberculosis and induces macrophage cell death. The host protein PHB2 was identified as a target molecule, and its overexpression reduced macrophage apoptosis in response to PE_PGRS30. The interaction between PE_PGRS30 and PHB2 occurs via the PGRS and mitochondrial targeting sequences, respectively, and results in mitochondrial dysfunction and cellular apoptosis.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Oncology
Sonia Nunez-Vazquez, Jose Saura-Esteller, Ismael Sanchez-Vera, Emma Guilbaud, Ana M. Cosialls, Gabriel Pons, Jean-Ehrland Ricci, Daniel Iglesias-Serret, Sandrine Marchetti, Joan Gil
Summary: Fluorizoline is a compound that binds prohibitin, triggering apoptosis and inhibiting mitophagy in various cell lines. It can act on both Parkin-dependent and Parkin-independent mitophagy processes.
Article
Multidisciplinary Sciences
Carlos Luan A. Passos, Renata Madureira Polinati, Christian Ferreira, Nathalia Alexia Nascimento dos Santos, Daniel Galinis V. Lima, Jerson Lima da Silva, Eliane Fialho
Summary: Curcumin and melphalan combination therapy has anticancer effects on breast cancer cells and represents a promising approach for clinical testing.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Srividya Subramanian, Sankar Pajaniradje, Roshan Tumdam, Mudassarul Hoda, Asmita Dasgupta, Rukkumani Rajagopalan
Summary: This study investigated the effects of an indole analog of curcumin on HBV-positive hepatocellular carcinoma cells and found that indole curcumin exhibited antiproliferative, pro-apoptotic, anti-migratory, and MMP-9 inhibitory effects on Hep3B cells.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2023)
Article
Environmental Sciences
Natsumi Fujiwara, Gary M. Whitford, John D. Bartlett, Maiko Suzuki
Summary: Curcumin can mitigate fluoride toxicity by modulating the p53-p21 pathway, inhibiting apoptosis induced by fluoride, and activating Akt to suppress fluoride-induced DNA damage.
ENVIRONMENTAL POLLUTION
(2021)
Article
Cell Biology
Fei Mo, Yinan Xiao, Hao Zeng, Dian Fan, Jinen Song, Xiaobei Liu, Meng Luo, Xuelei Ma
Summary: Curcumin has shown promise as a supplementary therapy in cancer treatment, with our research demonstrating its ability to increase apoptosis rate and downregulate cell cycle-related pathways in human small cell lung cancer cells. Additionally, miRNA-548ah-5p was identified as playing a negative role in curcumin's anticarcinogenic activity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yin Tong, Priscilla S. W. Cheng, Chung Sze Or, Sarah S. K. Yue, Hoi Cheong Siu, Siu Lun Ho, Simon Y. K. Law, Wai Yin Tsui, Dessy Chan, Stephanie Ma, Siu Po Lee, Annie S. Y. Chan, April S. Chan, Shui Wa Yun, Ho Sang Hui, Siu Tsan Yuen, Suet Yi Leung, Helen H. N. Yan
Summary: Cell-cell and cell-matrix adhesions play a critical role in gastric cancer progression, especially in gastric cancer with dysregulated RHO signaling.
Article
Oncology
Lisa von Wenserski, Christoph Schultheiss, Sarah Bolz, Simon Schliffke, Donjete Simnica, Edith Willscher, Helwe Gerull, Gerrit Wolters-Eisfeld, Kristoffer Riecken, Boris Fehse, Marcus Altfeld, Peter Nollau, Mascha Binder
Summary: SLAMF receptors were found to be important modulators of BCR signaling axis in CLL patients, potentially improving immune control by interfering with NK cells. The low expression of SLAMF1 and SLAMF7 was associated with decreased NK cell degranulation capacity and an unmutated CLL IGHV status.