The ω-transaminase engineering database (oTAED): A navigation tool in protein sequence and structure space

A Novel highly thermostable branched-chain amino acid aminotransferase from the crenarchaeon Vulcanisaeta moutnovskia

(2017) Tatiana N. Stekhanova et al.   ENZYME AND MICROBIAL TECHNOLOGY

Transaminase biocatalysis: optimization and application

(2017) Fei Guo et al.   GREEN CHEMISTRY

Percolation in protein sequence space

(2017) Patrick C. F. Buchholz et al.   PLoS One

Active Site Engineering of ω-Transaminase Guided by Docking Orientation Analysis and Virtual Activity Screening

(2017) Sang-Woo Han et al.   ACS Catalysis

Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts

(2017) Iustina Slabu et al.   ACS Catalysis

Catalytic Promiscuity of Transaminases: Preparation of Enantioenriched β-Fluoroamines by Formal Tandem Hydrodefluorination/Deamination

(2016) Aníbal Cuetos et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A β-Alanine Catabolism Pathway Containing a Highly Promiscuous ω-Transaminase in the 12-Aminododecanate-Degrading Pseudomonas sp. Strain AAC

(2016) Matthew Wilding et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Characterization of Four New Distinct ω-Transaminases from Pseudomonas putida NBRC 14164 for Kinetic Resolution of Racemic Amines and Amino Alcohols

(2016) Hua-Lei Wu et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Structural Basis of the Substrate Range and Enantioselectivity of Two (S)-Selective ω-Transaminases

(2016) Niels van Oosterwijk et al.   BIOCHEMISTRY

BioCatNet: A Database System for the Integration of Enzyme Sequences and Biocatalytic Experiments

(2016) Patrick C. F. Buchholz et al.   CHEMBIOCHEM

One-step purification and immobilization of a β-amino acid aminotransferase using magnetic (M-PVA) beads

(2016) Sarah-Marie Dold et al.   ENGINEERING IN LIFE SCIENCES

Biochemical characterization of thermostable ω-transaminase from Sphaerobacter thermophilus and its application for producing aromatic β- and γ-amino acids

(2016) Sam Mathew et al.   ENZYME AND MICROBIAL TECHNOLOGY

First structure of archaeal branched-chain amino acid aminotransferase from Thermoproteus uzoniensis specific for l-amino acids and R-amines

(2016) Konstantin M. Boyko et al.   EXTREMOPHILES

Identification of (S)-selective transaminases for the asymmetric synthesis of bulky chiral amines

(2016) Ioannis V. Pavlidis et al.   Nature Chemistry

Protein-engineering of an amine transaminase for the stereoselective synthesis of a pharmaceutically relevant bicyclic amine

(2016) Martin S. Weiß et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Identification of novel thermostable ω-transaminase and its application for enzymatic synthesis of chiral amines at high temperature

(2016) Sam Mathew et al.   RSC Advances

Discovery and structural characterisation of new fold type IV-transaminases exemplify the diversity of this enzyme fold

(2016) Tea Pavkov-Keller et al.   Scientific Reports

Mechanism-Guided Engineering of ω-Transaminase to Accelerate Reductive Amination of Ketones

(2015) Sang-Woo Han et al.   ADVANCED SYNTHESIS & CATALYSIS

Active-Site Engineering of ω-Transaminase for Production of Unnatural Amino Acids Carrying a Side Chain Bulkier than an Ethyl Substituent

(2015) Sang-Woo Han et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications

(2015) Fabian Steffen-Munsberg et al.   BIOTECHNOLOGY ADVANCES

Engineering the Active Site of the Amine Transaminase fromVibrio fluvialisfor the Asymmetric Synthesis of Aryl-Alkyl Amines and Amino Alcohols

(2015) Alberto Nobili et al.   ChemCatChem

Single active-site mutants are sufficient to enhance serine:pyruvate α-transaminase activity in an ω-transaminase

(2015) Dawid Deszcz et al.   FEBS Journal

Production of chiral β-amino acids using ω-transaminase from Burkholderia graminis

(2015) Sam Mathew et al.   JOURNAL OF BIOTECHNOLOGY

Structural Determinants for the Non-Canonical Substrate Specificity of the ω-Transaminase fromParacoccus denitrificans

(2014) Eul-Soo Park et al.   ADVANCED SYNTHESIS & CATALYSIS

Chiral Amine Synthesis Using ω-Transaminases: An Amine Donor that Displaces Equilibria and Enables High-Throughput Screening

(2014) Anthony P. Green et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metabolically driven equilibrium shift of asymmetric amination of ketones by ω-transaminase using alanine as an amino donor

(2014) Sang-Woo Han et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase

(2014) Nina Richter et al.   CHEMICAL COMMUNICATIONS

Structural and biochemical characterization of the dual substrate recognition of the (R)-selective amine transaminase fromAspergillus fumigatus

(2014) Lilly Skalden et al.   FEBS Journal

The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase fromNectria haematococca

(2014) Christopher Sayer et al.   FEBS Journal

Exploring the potential of endophytes from medicinal plants as sources of antimycobacterial compounds

(2014) Alfonsus Alvin et al.   MICROBIOLOGICAL RESEARCH

Crystal Structure of an (R)-Selective ω-Transaminase from Aspergillus terreus

(2014) Andrzej Łyskowski et al.   PLoS One

Crystallographic characterization of the (R)-selective amine transaminase fromAspergillus fumigatus

(2014) Maren Thomsen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural studies ofPseudomonasandChromobacteriumω-aminotransferases provide insights into their differing substrate specificity

(2013) Christopher Sayer et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Two Steps in One Pot: Enzyme Cascade for the Synthesis of Nor(pseudo)ephedrine from Inexpensive Starting Materials

(2013) Torsten Sehl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Artificial Multi-Enzyme Networks for the Asymmetric Amination ofsec-Alcohols

(2013) Katharina Tauber et al.   CHEMISTRY-A EUROPEAN JOURNAL

BacDive—the Bacterial Diversity Metadatabase

(2013) Carola Söhngen et al.   NUCLEIC ACIDS RESEARCH

Pfam: the protein families database

(2013) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

ω-Transaminase-catalyzed asymmetric synthesis of unnatural amino acids using isopropylamine as an amino donor

(2013) Eul-Soo Park et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Crystal structure of the ω-aminotransferase fromParacoccus denitrificansand its phylogenetic relationship with other class III amino- transferases that have biotechnological potential

(2013) Christian Rausch et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Asymmetric Bio-amination of Ketones in Organic Solvents

(2012) Francesco G. Mutti et al.   ADVANCED SYNTHESIS & CATALYSIS

Biochemical Properties and Crystal Structure of a β-Phenylalanine Aminotransferase from Variovorax paradoxus

(2012) Ciprian G. Crismaru et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Metabolic characteristics of the species Variovorax paradoxus

(2012) Barbara Satola et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Features and technical applications of ω-transaminases

(2012) M. Shaheer Malik et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A standard numbering scheme for thiamine diphosphate-dependent decarboxylases

(2012) Constantin Vogel et al.   BMC BIOCHEMISTRY

Revealing the Structural Basis of Promiscuous Amine Transaminase Activity

(2012) Fabian Steffen-Munsberg et al.   ChemCatChem

Key Amino Acid Residues for Reversed or Improved Enantiospecificity of an ω-Transaminase

(2012) Maria Svedendahl Humble et al.   ChemCatChem

Crystal structures of the Chromobacterium violaceumω-transaminase reveal major structural rearrangements upon binding of coenzyme PLP

(2012) Maria S. Humble et al.   FEBS Journal

Optimization to Low Temperature Activity in Psychrophilic Enzymes

(2012) Caroline Struvay et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural Determinants of the β-Selectivity of a Bacterial Aminotransferase

(2012) Gjalt G. Wybenga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromobacterium violaceum ω-transaminase variant Trp60Cys shows increased specificity for (S)-1-phenylethylamine and 4′-substituted acetophenones, and follows Swain–Lupton parameterisation

(2012) Karim Engelmark Cassimjee et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin

(2012) K. S. Midelfort et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Improved chemoenzymatic asymmetric synthesis of (S)-Rivastigmine

(2012) Michael Fuchs et al.   TETRAHEDRON

Transaminases for the synthesis of enantiopure beta-amino acids

(2012) Jens Rudat et al.   AMB Express

Stereoselectivity of Four (R)-Selective Transaminases for the Asymmetric Amination of Ketones

(2011) Francesco G. Mutti et al.   ADVANCED SYNTHESIS & CATALYSIS

A novel transaminase, (R)-amine:pyruvate aminotransferase, from Arthrobacter sp. KNK168 (FERM BP-5228): purification, characterization, and gene cloning

(2011) Akira Iwasaki et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Molecular determinants for substrate selectivity of ω-transaminases

(2011) Eul-Soo Park et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Pseudomonas aeruginosa 4-Amino-4-Deoxychorismate Lyase: Spatial Conservation of an Active Site Tyrosine and Classification of Two Types of Enzyme

(2011) Patrick E. F. O'Rourke et al.   PLoS One

Search and clustering orders of magnitude faster than BLAST

(2010) Robert C. Edgar   BIOINFORMATICS

Reversed Enantiopreference of an ω-Transaminase by a Single-Point Mutation

(2010) Maria Svedendahl et al.   ChemCatChem

Rational assignment of key motifs for function guides in silico enzyme identification

(2010) Matthias Höhne et al.   Nature Chemical Biology

GenBank

(2010) D. A. Benson et al.   NUCLEIC ACIDS RESEARCH

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

ω-Transaminases for the synthesis of non-racemic α-chiral primary amines

(2010) Dominik Koszelewski et al.   TRENDS IN BIOTECHNOLOGY

Rapid and Sensitive Kinetic Assay for Characterization of ω-Transaminases

(2009) Sebastian Schätzle et al.   ANALYTICAL CHEMISTRY

The B6 database: a tool for the description and classification of vitamin B6-dependent enzymatic activities and of the corresponding protein families

(2009) Riccardo Percudani et al.   BMC BIOINFORMATICS

Subcellular localization and expression of multiple tomato γ-aminobutyrate transaminases that utilize both pyruvate and glyoxylate

(2009) Shawn M. Clark et al.   JOURNAL OF EXPERIMENTAL BOTANY

Deracemization of Mexiletine Biocatalyzed by ω-Transaminases

(2009) Dominik Koszelewski et al.   ORGANIC LETTERS

Enantiocomplementary Enzymes: Classification, Molecular Basis for Their Enantiopreference, and Prospects for Mirror-Image Biotransformations

(2008) Paul F. Mugford et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION