Defective Repair of Oxidative Base Lesions by the DNA Glycosylase Nth1 Associates with Multiple Telomere Defects

CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion

(2012) Peili Gu et al.   EMBO JOURNAL

Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres

(2012) Silvia Remeseiro et al.   EMBO JOURNAL

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Base Excision Repair and Lesion-Dependent Subpathways for Repair of Oxidative DNA Damage

(2010) David Svilar et al.   ANTIOXIDANTS & REDOX SIGNALING

Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1

(2010) David B. Rhee et al.   DNA REPAIR

ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase

(2010) Carolyn J. McNees et al.   JOURNAL OF CELL BIOLOGY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Role of oxidatively induced DNA lesions in human pathogenesis

(2010) Olga A. Sedelnikova et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping

(2010) Sophie Badie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hyper telomere recombination accelerates replicative senescence and may promote premature aging

(2010) R. T. Hagelstrom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Telomeres Are Hypersensitive to UV-Induced DNA Damage and Refractory to Repair

(2010) Patrick J. Rochette et al.   PLoS Genetics

Characterization of Oxidative Guanine Damage and Repair in Mammalian Telomeres

(2010) Zhilong Wang et al.   PLoS Genetics

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA

(2009) Michael K. Chan et al.   DNA REPAIR

Deletion of Ogg1 DNA glycosylase results in telomere base damage and length alteration in yeast

(2009) Jian Lu et al.   EMBO JOURNAL

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

(2009) P. Martinez et al.   GENES & DEVELOPMENT

The Recombination Protein RAD52 Cooperates with the Excision Repair Protein OGG1 for the Repair of Oxidative Lesions in Mammalian Cells

(2009) N. C. de Souza-Pinto et al.   MOLECULAR AND CELLULAR BIOLOGY

A quantitative real-time PCR method for absolute telomere length

(2008) Nathan J. O'Callaghan et al.   BIOTECHNIQUES

Base excision repair of oxidative DNA damage and association with cancer and aging

(2008) S. Maynard et al.   CARCINOGENESIS

Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells

(2008) Muralidhar L Hegde et al.   CELL RESEARCH