Asymmetric damage segregation at cell division via protein aggregate fusion and attachment to organelles

Organelle-Based Aggregation and Retention of Damaged Proteins in Asymmetrically Dividing Cells

(2014) Chuankai Zhou et al.   CELL

The yeast peroxiredoxin Tsa1 protects against protein-aggregate-induced oxidative stress

(2014) A. J. Weids et al.   JOURNAL OF CELL SCIENCE

Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin

(2014) M. Ogrodnik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling

(2014) C. C. Williams et al.   SCIENCE

Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling

(2014) C. H. Jan et al.   SCIENCE

Fusion of Protein Aggregates Facilitates Asymmetric Damage Segregation

(2014) Miguel Coelho et al.   PLOS BIOLOGY

Essential Genetic Interactors of SIR2 Required for Spatial Sequestration and Asymmetrical Inheritance of Protein Aggregates

(2014) Jia Song et al.   PLoS Genetics

Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast

(2014) Kiersten A Henderson et al.   eLife

Fission Yeast Does Not Age under Favorable Conditions, but Does So after Stress

(2013) Miguel Coelho et al.   CURRENT BIOLOGY

Actin Dynamics Affect Mitochondrial Quality Control and Aging in Budding Yeast

(2013) Ryo Higuchi et al.   CURRENT BIOLOGY

The asymmetric segregation of damaged proteins is stem cell–type dependent

(2013) Mary Rose Bufalino et al.   JOURNAL OF CELL BIOLOGY

Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress

(2013) Stéphanie Escusa-Toret et al.   NATURE CELL BIOLOGY

Localization of Protein Aggregation in Escherichia coli Is Governed by Diffusion and Nucleoid Macromolecular Crowding Effect

(2013) Anne-Sophie Coquel et al.   PLoS Computational Biology

Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates

(2012) Liliana Malinovska et al.   MOLECULAR BIOLOGY OF THE CELL

An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

(2012) Adam L. Hughes et al.   NATURE

Tracking protein aggregation and mislocalization in cells with flow cytometry

(2012) Yasmin M Ramdzan et al.   NATURE METHODS

Segregation of molecules at cell division reveals native protein localization

(2012) Dirk Landgraf et al.   NATURE METHODS

Characterization of the Proteostasis Roles of Glycerol Accumulation, Protein Degradation and Protein Synthesis during Osmotic Stress in C. elegans

(2012) Kristopher Burkewitz et al.   PLoS One

Compartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity

(2012) S. J. Weisberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Confinement to Organelle-Associated Inclusion Structures Mediates Asymmetric Inheritance of Aggregated Protein in Budding Yeast

(2012) Rachel Spokoini et al.   Cell Reports

Motility and Segregation of Hsp104-Associated Protein Aggregates in Budding Yeast

(2011) Chuankai Zhou et al.   CELL

Segregation of Protein Aggregates Involves Actin and the Polarity Machinery

(2011) Beidong Liu et al.   CELL

Hsp42 is required for sequestration of protein aggregates into deposition sites inSaccharomyces cerevisiae

(2011) Sebastian Specht et al.   JOURNAL OF CELL BIOLOGY

The Polarisome Is Required for Segregation and Retrograde Transport of Protein Aggregates

(2010) Beidong Liu et al.   CELL

Quantitative and spatio-temporal features of protein aggregation in Escherichia coli and consequences on protein quality control and cellular ageing

(2010) Juliane Winkler et al.   EMBO JOURNAL

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE

Selective benefits of damage partitioning in unicellular systems and its effects on aging

(2008) N. Erjavec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asymmetric mitosis: Unequal segregation of proteins destined for degradation

(2008) L. C. Fuentealba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation

(2008) A. B. Lindner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA