Pigment Epithelium-Derived Factor Plays a Role in Alzheimer’s Disease by Negatively Regulating Aβ42

Alzheimer's disease: Elevated pigment epithelium-derived factor in the cerebrospinal fluid is mostly of systemic origin

(2017) Veronika Lang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Deficiency of pigment epithelium-derived factor in nasopharyngeal carcinoma cells triggers the epithelial–mesenchymal transition and metastasis

(2017) Ting Zhang et al.   Cell Death & Disease

Dynamic relationships between age, amyloid-β deposition, and glucose metabolism link to the regional vulnerability to Alzheimer’s disease

(2016) Hwamee Oh et al.   BRAIN

Impact of Age at Primary Breast Cancer on Contralateral Breast Cancer Risk inBRCA1/2Mutation Carriers

(2016) Alexandra J. van den Broek et al.   JOURNAL OF CLINICAL ONCOLOGY

PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases

(2015) Xuemin He et al.   CLINICAL SCIENCE

Blood–brain barrier endogenous transporters as therapeutic targets: a new model for small molecule CNS drug discovery

(2015) William M Pardridge   EXPERT OPINION ON THERAPEUTIC TARGETS

The Voltage-dependent Anion Channel 1 Mediates Amyloid β Toxicity and Represents a Potential Target for Alzheimer Disease Therapy

(2015) Angela Smilansky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production

(2015) Junfeng Wang et al.   Nature Communications

Proapoptotic PEDF functional peptides inhibit prostate tumor growth—A mechanistic study

(2014) Qing Gong et al.   BIOCHEMICAL PHARMACOLOGY

Pigment epithelium-derived factor (PEDF) inhibits breast cancer metastasis by down-regulating fibronectin

(2014) Honghai Hong et al.   BREAST CANCER RESEARCH AND TREATMENT

High Levels of Pigment Epithelium–Derived Factor in Diabetes Impair Wound Healing Through Suppression of Wnt Signaling

(2014) Weiwei Qi et al.   DIABETES

Impact of age, age at diagnosis and duration of diabetes on the risk of macrovascular and microvascular complications and death in type 2 diabetes

(2014) Sophia Zoungas et al.   DIABETOLOGIA

Pigment Epithelial-derived Factor (PEDF)-triggered Lung Cancer Cell Apoptosis Relies on p53 Protein-driven Fas Ligand (Fas-L) Up-regulation and Fas Protein Cell Surface Translocation

(2014) Lei Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sildenafil Decreases BACE1 and Cathepsin B Levels and Reduces APP Amyloidogenic Processing in the SAMP8 Mouse

(2014) Lourdes Orejana et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer’s Disease

(2014) Chia-Chen Liu et al.   NEURON

Differences in amyloid-β clearance across mouse and human blood–brain barrier models: Kinetic analysis and mechanistic modeling

(2014) Hisham Qosa et al.   NEUROPHARMACOLOGY

Dual regulation of adipose triglyceride lipase by pigment epithelium-derived factor: A novel mechanistic insight into progressive obesity

(2013) Zhiyu Dai et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

C1q/TNF-Related Protein-3 (CTRP-3) and Pigment Epithelium-Derived Factor (PEDF) Concentrations in Patients With Type 2 Diabetes and Metabolic Syndrome

(2012) K. M. Choi et al.   DIABETES

Combined measurement of PEDF, haptoglobin and tau in cerebrospinal fluid improves the diagnostic discrimination between alzheimer’s disease and other dementias

(2011) Jean-Daniel Abraham et al.   BIOMARKERS

Combination of pigment epithelium-derived factor with radiotherapy enhances the antitumor effects on nasopharyngeal carcinoma by downregulating vascular endothelial growth factor expression and angiogenesis

(2011) Zumin Xu et al.   CANCER SCIENCE

Endothelial Smad4 Maintains Cerebrovascular Integrity by Activating N-Cadherin through Cooperation with Notch

(2011) Fangfei Li et al.   DEVELOPMENTAL CELL

Pigment Epithelium-Derived Factor Regulates Lipid Metabolism via Adipose Triglyceride Lipase

(2011) M. L. Borg et al.   DIABETES

A Stage-for-Stage and Grade-for-Grade Analysis of Cancer-Specific Mortality Rates in Renal Cell Carcinoma According to Age: A Competing-Risks Regression Analysis

(2011) Maxine Sun et al.   EUROPEAN UROLOGY

Autophagy impairment stimulates PS1 expression and γ-secretase activity

(2010) Kazunori Ohta et al.   Autophagy

JNK: A Stress-Activated Protein Kinase Therapeutic Strategies and Involvement in Alzheimer’s and Various Neurodegenerative Abnormalities

(2010) Sidharth Mehan et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Adenoviral Gene Delivery of Pigment Epithelium-Derived Factor Protects Striatal Neurons from Quinolinic Acid-Induced Excitotoxicity

(2010) Tomomi Sanagi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer’s disease

(2009) Alex E. Roher et al.   BIOMARKERS

Pigment Epithelium-Derived Factor Contributes to Insulin Resistance in Obesity

(2009) Seamus Crowe et al.   Cell Metabolism

Increase in Presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing

(2009) V. B. Kumar et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Intracellular Amyloid β-Protein As a Therapeutic Target for Treating Alzheimers Disease

(2008) Y. Ohyagi   Current Alzheimer Research

Ethanol Exposure Depletes Hepatic Pigment Epithelium-Derived Factor, a Novel Lipid Regulator

(2008) Chuhan Chung et al.   GASTROENTEROLOGY

Gene transfer of PEDF attenuates ischemic brain damage in the rat middle cerebral artery occlusion model

(2008) Tomomi Sanagi et al.   JOURNAL OF NEUROCHEMISTRY