Article
Respiratory System
Xichun Qin, Caili Jia, Jingtian Liang, Jiali Chen, Xiucheng Liu, Zhixiang Chao, Hao Qin, Yanliang Yuan, Zhiwei Liu, Zhongming Zhang, Hongyan Dong, Hao Zhang
Summary: This study demonstrates that PEDF can act as an anti-fibrotic factor, inhibiting fibroblast activation by upregulating PPAR-gamma activity and reducing bleomycin-induced pulmonary fibrosis in rats.
RESPIRATORY RESEARCH
(2022)
Article
Chemistry, Medicinal
Jae Seok Yoon, Hyo-Jung Lee, Deok Yong Sim, Eunji Im, Ji Eon Park, Woon Yi Park, Ja Il Koo, Bum Sang Shim, Sung-Hoon Kim
Summary: Moracin D induces apoptosis in DU145 prostate cancer cells through activation of PPAR-gamma/p-PKC-delta signaling and inhibition of p-PKC-alpha. It downregulates caspase-3 and PARP expression, with DU145 cells showing higher sensitivity compared to PC3 cells. This highlights a novel mechanism by which Moracin D exerts its cytotoxic effects in prostate cancer.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Laura C. A. Galbraith, Ernest Mui, Colin Nixon, Ann Hedley, David Strachan, Gillian MacKay, David Sumpton, Owen J. Sansom, Hing Y. Leung, Imran Ahmad
Summary: The study demonstrates the association between PPARG and metastasis in prostate cancer, with PPARG over-expression leading to increased levels of AKT3, which in turn enhances PGC1α localization in the nucleus, driving mitochondrial biogenesis and providing higher energetic output for tumor cell progression towards metastasis through EMT.
Article
Biochemistry & Molecular Biology
Jorge Antonio Silva-Gomez, Marina Galicia-Moreno, Ana Sandoval-Rodriguez, Hipolito Otoniel Miranda-Roblero, Silvia Lucano-Landeros, Arturo Santos, Hugo Christian Monroy-Ramirez, Juan Armendariz-Borunda
Summary: The study evaluated the effects of PFD on early stages of liver cancer development, showing that PFD can prevent tissue damage, reduce fibrosis and inflammation, and promote apoptosis in the experimental model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Respiratory System
Lei Xu, Yifei Chen, Shoujie Feng, Zeyan Liu, Ying Ye, Ranran Zhou, Lijun Liu
Summary: This study found that PEDF can inhibit LPS-induced ALI in rats and reduce the expression of inflammatory factors and lung cell apoptosis. PEDF inhibits lung epithelial cell injury by upregulating the expression of PPAR-gamma.
BMC PULMONARY MEDICINE
(2023)
Article
Oncology
Yong Hao, Shuwei Bai, Jing Peng, Ronghua Hong, Jie Ding, Zezhi Li, Yangtai Guan
Summary: The study suggests that TRIM27 mediates ubiquitination of PPAR gamma, leading to increased expression of cleaved Caspase-3 and IL-1 beta, promoting Glu-induced apoptosis and IL-1 beta release in HT22 cells.
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Oncology
Tiange Chi, Mina Wang, Xu Wang, Ke Yang, Feiyu Xie, Zehuan Liao, Peng Wei
Summary: PPARs are lipid sensors and metabolic regulators, with PPAR-γ showing potential in inhibiting cell proliferation, inducing apoptosis, and disrupting inflammation. However, safety concerns including drug interactions need to be addressed for clinical applications.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Jiacheng Zhang, Gang He, Xi Jin, Bandar T. Alenezi, Abdulghani A. Naeem, Saud A. Abdulsamad, Youqiang Ke
Summary: Previous work showed that FABP5 inhibitors suppress the malignant progression of prostate cancer cells by promoting apoptosis. This study further investigated the mechanisms involved and found that the inhibitors reduce the activity of PPAR gamma and alter the AKT and NF kappa B signaling pathways, leading to increased apoptosis in cancer cells.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Cell Biology
Enrica Flori, Sarah Mosca, Giorgia Cardinali, Stefania Briganti, Monica Ottaviani, Daniela Kovacs, Isabella Manni, Mauro Truglio, Arianna Mastrofrancesco, Marco Zaccarini, Carlo Cota, Giulia Piaggio, Mauro Picardo
Summary: The PPAR gamma activators Octa and A02 may prevent and treat keratinocyte-derived skin cancer by inhibiting the epithelial-mesenchymal transition and reducing DNA damage.
Article
Health Care Sciences & Services
Betul Cicek, Sidika Genc, Yesim Yeni, Mehmet Kuzucu, Ahmet Cetin, Serkan Yildirim, Ismail Bolat, Mecit Kantarci, Ahmet Hacimuftuoglu, Georgios Lazopoulos, Aristidis Tsatsakis, Konstantinos Tsarouhas, Ali Taghizadehghalehjoughi
Summary: This study aimed to investigate the beneficial effects of artichoke leaf extract on DEN-induced brain toxicity. The results showed that high-dose artichoke treatment effectively improved impaired neuronal function and oxidative stress induced by DEN, and significantly increased the levels of neuroprotective factors Klotho and PPAR gamma.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Suliman Almahmoud, Catherine C. Elix, Jeremy O. Jones, Corey R. Hopkins, Jonathan L. Vennerstrom, Haizhen A. Zhong
Summary: The PPAR gamma antagonist is crucial for inhibiting prostate cancer cell growth, and residues Arg288, Lys367, and His449 are important for PPAR gamma antagonist binding.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Review
Immunology
Daniel Toobian, Pradipta Ghosh, Gajanan D. Katkar
Summary: This review article focuses on the potential roles of peroxisome proliferator-activated receptors (PPARs) in macrophage biology, as well as the modulation of immune cell function, microbial infection, and inflammatory diseases by dual and pan PPAR agonists.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Inorganic & Nuclear
Sijia Tu, Chaofeng Shen, Xinghua Bai, Huihui Zhang, Sara Amirpour Amraii, Danfeng Dai
Summary: Nanotechnology provides a cost-effective way to apply metal-oxidizing nanoparticles for cardiovascular protection. Copper nanoparticles derived from Berberis vulgaris leaf extract have been found to exert cardioprotective effects against myocardial ischemia in mice. These effects may be associated with the activation of peroxisome proliferator-activated receptor gamma (PPAR-gamma) and inhibition of nuclear factor kappa B (NF-kappa B) signaling.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Oncology
Xiao-Wei Song, Ting Su, Bo Li, Yun-Jie Huang, Wen-Xia He, Li-Li Jiang, Chang-Jin Li, Song-Qun Huang, Song-Hua Li, Zhi-Fu Guo, Hong Wu, Bi-Li Zhang
Summary: In this study, the role of the lncRNA PRKAG2-AS in regulating the expression of PRKAG2 in cardiomyocytes was investigated. Knockdown of PRKAG2-AS in the nucleus significantly decreased the expression of PRKAG2b and PRKAG2d. PRKAG2-AS and its target genes were reduced in the hearts of patients with ischemic cardiomyopathy, suggesting a potential role in myocardial ischemia. Overexpression of PPARG, a interacting protein of PRKAG2-AS, led to an increase in PRKAG2b and PRKAG2d expression in cardiomyocytes, which could be attenuated by PRKAG2-AS knockdown. Additionally, PRKAG2-AS was elevated in hearts with dilated cardiomyopathy and its overexpression led to increased PRKAG2 expression, indicating its involvement in heart failure.
CLINICAL EPIGENETICS
(2023)
Article
Oncology
Alessia Filippone, Giovanna Casili, Sarah Adriana Scuderi, Deborah Mannino, Marika Lanza, Michela Campolo, Irene Paterniti, Anna Paola Capra, Cristina Colarossi, Annalisa Bonasera, Sofia Paola Lombardo, Salvatore Cuzzocrea, Emanuela Esposito
Summary: This study investigates the interaction between propionate and PPAR-gamma in glioblastoma and suggests that targeting the PPAR-gamma/SCFAs axis may be a potential therapeutic approach for the management of glioblastoma.
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)