Sildenafil Decreases BACE1 and Cathepsin B Levels and Reduces APP Amyloidogenic Processing in the SAMP8 Mouse

Phosphodiesterase-5 inhibitor sildenafil prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in APP/PS1 transgenic mice

(2013) Junfang Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate

(2013) Lucía Barros-Miñones et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Phosphodiesterase 5 inhibition at disease onset prevents experimental autoimmune encephalomyelitis progression through immunoregulatory and neuroprotective actions

(2013) Paula Pifarré et al.   EXPERIMENTAL NEUROLOGY

Differential roles of the dorsal and ventral hippocampus in predator odor contextual fear conditioning

(2013) Melissa E. Wang et al.   HIPPOCAMPUS

Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice

(2013) Daniela Puzzo et al.   NEUROBIOLOGY OF AGING

Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus

(2013) Mazen A. Kheirbek et al.   NEURON

Calpain Inhibitor A-705253 Mitigates Alzheimer's Disease–Like Pathology and Cognitive Decline in Aged 3xTgAD Mice

(2012) Rodrigo Medeiros et al.   AMERICAN JOURNAL OF PATHOLOGY

Modulation of the ASK1-MKK3/6-p38/MAPK signalling pathway mediates sildenafil protection against chemical hypoxia caused by malonate

(2012) L Barros-Miñones et al.   BRITISH JOURNAL OF PHARMACOLOGY

BACE1 Dependent Neuregulin Processing: Review

(2012) Daniel Fleck et al.   Current Alzheimer Research

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

(2012) Philip T.T. Ly et al.   JOURNAL OF CLINICAL INVESTIGATION

Alterations in local thyroid hormone signaling in the hippocampus of the SAMP8 mouse at younger ages: Association with delayed myelination and behavioral abnormalities

(2012) Erika Sawano et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

The novel calpain inhibitor A-705253 prevents stress-induced tau hyperphosphorylation in vitro and in vivo

(2012) Arthur L. Nikkel et al.   NEUROPHARMACOLOGY

Sildenafil Enhances Neurogenesis and Oligodendrogenesis in Ischemic Brain of Middle-Aged Mouse

(2012) Rui Lan Zhang et al.   PLoS One

Sildenafil (Viagra) ameliorates clinical symptoms and neuropathology in a mouse model of multiple sclerosis

(2011) Paula Pifarre et al.   ACTA NEUROPATHOLOGICA

Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease

(2011) M Cuadrado-Tejedor et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology

(2011) Makoto Higuchi et al.   FASEB JOURNAL

Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model

(2011) Lourdes Orejana et al.   NEUROBIOLOGY OF AGING

Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice

(2011) Jose Morales-Corraliza et al.   NEUROBIOLOGY OF AGING

The Phosphatidyl Inositol 3 Kinase-Glycogen Synthase Kinase 3β Pathway Mediates Bilobalide-Induced Reduction in Amyloid β-Peptide

(2011) Chun Shi et al.   NEUROCHEMICAL RESEARCH

7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease

(2011) Latha Devi et al.   NEUROPSYCHOPHARMACOLOGY

Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce β-amyloid related to Alzheimer's disease

(2010) Vivian Hook et al.   BIOLOGICAL CHEMISTRY

Atorvastatin prevents hippocampal cell death, neuroinflammation and oxidative stress following amyloid-β1–40 administration in mice: Evidence for dissociation between cognitive deficits and neuronal damage

(2010) Tetsadê C.B. Piermartiri et al.   EXPERIMENTAL NEUROLOGY

Calpain Activation Promotes BACE1 Expression, Amyloid Precursor Protein Processing, and Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease

(2010) Bin Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Noncompetitive BACE1 Inhibitor TAK-070 Ameliorates A  Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease

(2010) H. Fukumoto et al.   JOURNAL OF NEUROSCIENCE

Cyclic GMP and Nitric Oxide Synthase in Aging and Alzheimer's Disease

(2010) Katarzyna Urszula Domek-Łopacińska et al.   MOLECULAR NEUROBIOLOGY

Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF

(2010) Elena Puerta et al.   NEUROBIOLOGY OF DISEASE

Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury

(2009) Paula Pifarré et al.   JOURNAL OF NEUROCHEMISTRY

Lithium Treatment Decreases Activities of Tau Kinases in a Murine Model of Senescence

(2009) Marta Tajes et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Phosphodiesterase 5 Inhibition Improves Synaptic Function, Memory, and Amyloid-  Load in an Alzheimer's Disease Mouse Model

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

The  -Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

(2009) R. Vassar et al.   JOURNAL OF NEUROSCIENCE

Nitric Oxide Activity and Isoenzyme Expression in the Senescence-Accelerated Mouse P8 Model of Alzheimer's Disease: Effects of Anti-Amyloid Antibody and Antisense Treatments

(2009) A. K. Ali et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

(2009) L. Serenó et al.   NEUROBIOLOGY OF DISEASE

Neurochemistry, Neuropathology, and Heredity in SAMP8: A Mouse Model of Senescence

(2009) Koji Tomobe et al.   NEUROCHEMICAL RESEARCH

Alternative pathways for production of β-amyloid peptides of Alzheimer's disease

(2008) Vivian Hook et al.   BIOLOGICAL CHEMISTRY

The effect of selective inhibition of cyclic GMP hydrolyzing phosphodiesterases 2 and 5 on learning and memory processes and nitric oxide synthase activity in brain during aging

(2008) K. Domek-Łopacińska et al.   BRAIN RESEARCH

Phosphodiesterase 5 inhibitors prevent 3,4-methylenedioxymethamphetamine-induced 5-HT deficits in the rat

(2008) Elena Puerta et al.   JOURNAL OF NEUROCHEMISTRY

Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing

(2008) Yi Wen et al.   NEURON

Minoxidil prevents 3,4-methylenedioxymethamphetamine-induced serotonin depletions: role of mitochondrial ATP-sensitive potassium channels, Akt and ERK

(2007) Beatriz Goñi-Allo et al.   JOURNAL OF NEUROCHEMISTRY