The aggregation of mutant p53 produces prion-like properties in cancer

Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome

(2015) Paul M. Neilsen et al.   Oncotarget

Gain-of-function p53 mutants have widespread genomic locations partially overlapping with p63.

(2015) Elena Martynova et al.   Oncotarget

Proteostasis and neurodegeneration: The roles of proteasomal degradation and autophagy

(2013) Keiji Tanaka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Expanding the prion concept to cancer biology: dominant-negative effect of aggregates of mutant p53 tumour suppressor

(2013) Jerson L. Silva et al.   BIOSCIENCE REPORTS

Folding of a Cyclin Box

(2013) Lucía B. Chemes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prion-Like Propagation of Protein Aggregation and Related Therapeutic Strategies

(2013) Sarah K. Kaufman et al.   Neurotherapeutics

Principles of self-organization in biological pathways: a hypothesis on the autogenous association of alpha-synuclein

(2013) Andreas Zanzoni et al.   NUCLEIC ACIDS RESEARCH

Small molecule induced reactivation of mutant p53 in cancer cells

(2013) Xiangrui Liu et al.   NUCLEIC ACIDS RESEARCH

p53 Aggregates Penetrate Cells and Induce the Co-Aggregation of Intracellular p53

(2013) Karolyn J. Forget et al.   PLoS One

Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity

(2012) Cristian A. Lasagna-Reeves et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils

(2012) Ana P. D. Ano Bom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Generic Crystallization-like Model That Describes the Kinetics of Amyloid Fibril Formation

(2012) Rosa Crespo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trans-cellular Propagation of Tau Aggregation by Fibrillar Species

(2012) Najla Kfoury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Hyperphosphorylation and Cleavage at D421 Enhance Tau Secretion

(2012) Vanessa Plouffe et al.   PLoS One

Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2

(2012) Milena Wiech et al.   PLoS One

Transient Transfection of a Wild-Type p53 Gene Triggers Resveratrol-Induced Apoptosis in Cancer Cells

(2012) Danielly Cristiny Ferraz da Costa et al.   PLoS One

An Intrinsically Disordered Region of the Acetyltransferase p300 with Similarity to Prion-Like Domains Plays a Role in Aggregation

(2012) Alexander Kirilyuk et al.   PLoS One

First-order rate-determining aggregation mechanism of p53 and its implications

(2012) G. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition

(2012) R. Wilcken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential roles for prions and protein-only inheritance in cancer

(2011) H. Antony et al.   CANCER AND METASTASIS REVIEWS

Cholesterol Secosterol Aldehydes Induce Amyloidogenesis and Dysfunction of Wild-Type Tumor Protein p53

(2011) Jorge Nieva et al.   CHEMISTRY & BIOLOGY

Protein aggregation and amyloid fibril formation prediction software from primary sequence: towards controlling the formation of bacterial inclusion bodies

(2011) Stavros J. Hamodrakas   FEBS Journal

RNAi: a potential new class of therapeutic for human genetic disease

(2011) Attila A. Seyhan   HUMAN GENETICS

A Seeding Reaction Recapitulates Intracellular Formation of Sarkosyl-insoluble Transactivation Response Element (TAR) DNA-binding Protein-43 Inclusions

(2011) Yoshiaki Furukawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exogenous seeding of cerebral β-amyloid deposition in βAPP-transgenic rats

(2011) Rebecca F. Rosen et al.   JOURNAL OF NEUROCHEMISTRY

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

(2011) Jie Xu et al.   Nature Chemical Biology

Intermolecular transmission of superoxide dismutase 1 misfolding in living cells

(2011) L. I. Grad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity, biogenesis and function of microbial amyloids

(2011) Luz P. Blanco et al.   TRENDS IN MICROBIOLOGY

Protein Solubility and Protein Homeostasis: A Generic View of Protein Misfolding Disorders

(2011) M. Vendruscolo et al.   Cold Spring Harbor Perspectives in Biology

Current strategies to target p53 in cancer

(2010) Fang Chen et al.   BIOCHEMICAL PHARMACOLOGY

p53 as the main traffic controller of the cell signaling network

(2010) Sinto Sebastian   Frontiers in Bioscience-Landmark

Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors

(2010) Claudia B. Levy et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Heparin Binding by Murine Recombinant Prion Protein Leads to Transient Aggregation and Formation of RNA-Resistant Species

(2010) Tuane C. R. G. Vieira et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability

(2010) L Latonen et al.   ONCOGENE

Prion hypothesis: the end of the controversy?

(2010) Claudio Soto   TRENDS IN BIOCHEMICAL SCIENCES

Ligand Binding and Hydration in Protein Misfolding: Insights from Studies of Prion and p53 Tumor Suppressor Proteins†

(2009) Jerson L. Silva et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cognate DNA Stabilizes the Tumor Suppressor p53 and Prevents Misfolding and Aggregation

(2009) Daniella Ishimaru et al.   BIOCHEMISTRY

PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

(2009) Jeremy M.R. Lambert et al.   CANCER CELL

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

(2009) Adriano Aguzzi et al.   NEURON

Structural Biology of the Tumor Suppressor p53

(2008) Andreas C. Joerger et al.   Annual Review of Biochemistry

The (1–63) Region of the p53 Transactivation Domain Aggregates In Vitro into Cytotoxic Amyloid Assemblies

(2008) Stefania Rigacci et al.   BIOPHYSICAL JOURNAL

The Zyggregator method for predicting protein aggregation propensities

(2008) Gian Gaetano Tartaglia et al.   CHEMICAL SOCIETY REVIEWS

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway

(2008) J. E. Kravchenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fecal transmission of AA amyloidosis in the cheetah contributes to high incidence of disease

(2008) B. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intriguing nucleic-acid-binding features of mammalian prion protein

(2008) Jerson L. Silva et al.   TRENDS IN BIOCHEMICAL SCIENCES