Aβ degradation or cerebral perfusion? Divergent effects of multifunctional enzymes

Accumulation of Insoluble Amyloid-β in Down's Syndrome is Associated with Increased BACE-1 and Neprilysin Activities

(2018) James Scott Miners et al.   JOURNAL OF ALZHEIMERS DISEASE

Associations of Anti-Hypertensive Treatments with Alzheimer's Disease, Vascular Dementia, and Other Dementias

(2018) Neil M. Davies et al.   JOURNAL OF ALZHEIMERS DISEASE

Endothelin-A Receptor Antagonists Prevent Amyloid-β-Induced Increase in ETA Receptor Expression, Oxidative Stress, and Cognitive Impairment

(2018) Seema Briyal et al.   JOURNAL OF ALZHEIMERS DISEASE

Quantitative Assessment of Cerebral Hemodynamic Parameters by QUASAR Arterial Spin Labeling in Alzheimer's Disease and Cognitively Normal Elderly Adults at 3-Tesla

(2018) Henry K.F. Mak et al.   JOURNAL OF ALZHEIMERS DISEASE

Angiotensin-Converting Enzyme and Progression of White Matter Lesions and Brain Atrophy – The SMART-MR Study

(2018) Hadassa M. Jochemsen et al.   JOURNAL OF ALZHEIMERS DISEASE

Endothelin-1 is Elevated in Alzheimer's Disease and Upregulated by Amyloid-β

(2018) Jennifer C. Palmer et al.   JOURNAL OF ALZHEIMERS DISEASE

Associations of Angiotensin Targeting Antihypertensive Drugs with Mortality and Hospitalization in Primary Care Patients with Dementia

(2018) Patrick Gavin Kehoe et al.   JOURNAL OF ALZHEIMERS DISEASE

Endothelin-Converting Enzyme-1 Activity, Endothelin-1 Production, and Free Radical-Dependent Vasoconstriction in Alzheimer's Disease

(2018) Jennifer C. Palmer et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of Centrally Acting Angiotensin Converting Enzyme Inhibitors on Functional Decline in Patients with Alzheimer's Disease

(2018) Rónán O'Caoimh et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of 4-Hydroxy-Nonenal and Amyloid-β on Expression and Activity of Endothelin Converting Enzyme and Insulin Degrading Enzyme in SH-SY5Y Cells

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Endothelin-1 is Elevated in Alzheimer's Disease Brain Microvessels and is Neuroprotective

(2017) Jinhua Luo et al.   JOURNAL OF ALZHEIMERS DISEASE

Higher Cathepsin B Levels in Plasma in Alzheimer's Disease Compared to Healthy Controls

(2017) Johan Sundelöf et al.   JOURNAL OF ALZHEIMERS DISEASE

Pathophysiology of white matter perfusion in Alzheimer’s disease and vascular dementia

(2014) Rachel Barker et al.   BRAIN

Reduced Vascular Endothelial Growth Factor and Capillary Density in the Occipital Cortex in Dementia with Lewy Bodies

(2014) Scott Miners et al.   BRAIN PATHOLOGY

Endothelin receptor type B agonist, IRL-1620, prevents beta amyloid (Aβ) induced oxidative stress and cognitive impairment in normal and diabetic rats

(2014) Seema Briyal et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Quantitative Variation in Plasma Angiotensin-I Converting Enzyme Activity Shows Allelic Heterogeneity in theABOBlood Group Locus

(2013) Chikashi Terao et al.   ANNALS OF HUMAN GENETICS

Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β

(2013) Simon J. Henderson et al.   BRAIN

Current status of renin–aldosterone angiotensin system-targeting anti-hypertensive drugs as therapeutic options for Alzheimer's disease

(2013) Emma Louise Ashby et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Assessing White Matter Ischemic Damage in Dementia Patients by Measurement of Myelin Proteins

(2013) Rachel Barker et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Enhanced Proteolytic Clearance of Plasma A  by Peripherally Administered Neprilysin Does Not Result in Reduced Levels of Brain A  in Mice

(2013) J. R. Walker et al.   JOURNAL OF NEUROSCIENCE

Metabolism of amyloid ^|^beta; peptide and pathogenesis of Alzheimer^|^rsquo;s disease

(2013) Takaomi C. SAIDO   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Effects of centrally acting ACE inhibitors on the rate of cognitive decline in dementia

(2013) Yang Gao et al.   BMJ Open

Serum angiotensin-converting enzyme and recurrent vascular events. The SMART-MR study

(2012) Hadassa M. Jochemsen et al.   ATHEROSCLEROSIS

Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains

(2012) Minjie Tian et al.   FEBS LETTERS

Endothelin-1 induces hypoxia inducible factor 1α expression in pulmonary artery smooth muscle cells

(2012) Manxiang Li et al.   FEBS LETTERS

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

(2011) Cheryl A. Hawkes et al.   ACTA NEUROPATHOLOGICA

Neprilysin-2 Is an Important β-Amyloid Degrading Enzyme

(2011) Daniel Hafez et al.   AMERICAN JOURNAL OF PATHOLOGY

The PPARγ ligand rosiglitazone attenuates hypoxia-induced endothelin signaling in vitro and in vivo

(2011) Bum-Yong Kang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cerebrovascular lesions induce transient  -amyloid deposition

(2011) M. Garcia-Alloza et al.   BRAIN

Cerebral autoregulation in Alzheimer's disease

(2011) Jurgen AHR Claassen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Aβ-Degrading Enzymes: Potential for Treatment of Alzheimer Disease

(2011) James Scott Miners et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cerebral ischemia aggravates cognitive impairment in a rat model of Alzheimer's disease

(2011) Jing Li et al.   LIFE SCIENCES

Central Angiotensin II Stimulation Promotes β Amyloid Production in Sprague Dawley Rats

(2011) Donglin Zhu et al.   PLoS One

Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aβ Toxicity in a Mouse Model of Alzheimer's Disease

(2011) Brian Spencer et al.   PLoS One

Hypoxia Due to Cardiac Arrest Induces a Time-Dependent Increase in Serum Amyloid β Levels in Humans

(2011) Henrik Zetterberg et al.   PLoS One

Vascular risk factors and Alzheimer's disease: are these risk factors for plaques and tangles or for concomitant vascular pathology that increases the likelihood of dementia? An evidence-based review

(2011) Helena C Chui et al.   Alzheimers Research & Therapy

Association cortex hypoperfusion in mild dementia with Lewy bodies: a potential indicator of cholinergic dysfunction?

(2010) Tamara G. Fong et al.   Brain Imaging and Behavior

Changes with Age in the Activities of β-Secretase and the Aβ-Degrading Enzymes Neprilysin, Insulin-Degrading Enzyme and Angiotensin-Converting Enzyme

(2010) J. Scott Miners et al.   BRAIN PATHOLOGY

Plasminogen and plasmin in Alzheimer's disease

(2010) Rachel Barker et al.   BRAIN RESEARCH

Role of Vascular Risk Factors and Vascular Dysfunction in Alzheimer's Disease

(2010) Dara L. Dickstein et al.   MOUNT SINAI JOURNAL OF MEDICINE

Endothelin-converting enzyme-1 in Alzheimer's disease and vascular dementia

(2010) J. C. Palmer et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Endothelin receptor antagonists: Potential in Alzheimer's disease

(2010) Jennifer Palmer et al.   PHARMACOLOGICAL RESEARCH

Protective Effects of Intranasal Losartan in the APP/PS1 Transgenic Mouse Model of Alzheimer Disease

(2010) Lusine Danielyan et al.   REJUVENATION RESEARCH

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Microvasculature changes and cerebral amyloid angiopathy in Alzheimer’s disease and their potential impact on therapy

(2009) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging

(2009) Norbert Schuff et al.   Alzheimers & Dementia

Endothelin-Converting Enzyme-2 Is Increased in Alzheimer’s Disease and Up-Regulated by Aβ

(2009) Jennifer C. Palmer et al.   AMERICAN JOURNAL OF PATHOLOGY

Neprilysin and Insulin-Degrading Enzyme Levels Are Increased in Alzheimer Disease in Relation to Disease Severity

(2009) James Scott Miners et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Increased Matrix Metalloproteinase 9 Activity in Mild Cognitive Impairment

(2009) Martin A. Bruno et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide

(2009) Rina Yamin et al.   Molecular Neurodegeneration

Expression of Neprilysin in Skeletal Muscle Reduces Amyloid Burden in a Transgenic Mouse Model of Alzheimer Disease

(2009) Yinxing Liu et al.   MOLECULAR THERAPY

Upregulation of BACE1 and β-Amyloid Protein Mediated by Chronic Cerebral Hypoperfusion Contributes to Cognitive Impairment and Pathogenesis of Alzheimer’s Disease

(2009) Cai Zhiyou et al.   NEUROCHEMICAL RESEARCH

Angiotensins in Alzheimer's disease – friend or foe?

(2009) Patrick G. Kehoe et al.   TRENDS IN NEUROSCIENCES

Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease

(2009) Roy O Weller et al.   Alzheimers Research & Therapy

Neprilysin: An Enzyme Candidate to Slow the Progression of Alzheimer's Disease

(2008) Salim S. El-Amouri et al.   AMERICAN JOURNAL OF PATHOLOGY

Adaptation to chronic hypoxia involves immune cell invasion and increased expression of inflammatory cytokines in rat carotid body

(2008) Frank L. Powell   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Interaction of angiotensin-converting enzyme (ACE) with membrane-bound carboxypeptidase M (CPM) – a new function of ACE

(2008) Xiaoou Sun et al.   BIOLOGICAL CHEMISTRY

Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice

(2008) Brian Spencer et al.   BMC NEUROSCIENCE

Effects of HNE-modification induced by Aβ on neprilysin expression and activity in SH-SY5Y cells

(2008) Rui Wang et al.   JOURNAL OF NEUROCHEMISTRY

The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α

(2008) Michela Guglielmotto et al.   JOURNAL OF NEUROCHEMISTRY

Peripherally expressed neprilysin reduces brain amyloid burden: A novel approach for treating Alzheimer's disease

(2008) Hanjun Guan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Activation of the Amyloid Cascade by Intracerebroventricular Injection of the Protease Inhibitor Phosphoramidon

(2008) Yotam Nisemblat et al.   Neurodegenerative Diseases

Alzheimer’s disease risk variants show association with cerebrospinal fluid amyloid beta

(2008) John S. K. Kauwe et al.   NEUROGENETICS

Transcriptional responses to intermittent hypoxia

(2008) Jayasri Nanduri et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Candidate Single-Nucleotide Polymorphisms From a Genomewide Association Study of Alzheimer Disease

(2007) Hao Li et al.   ARCHIVES OF NEUROLOGY

Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis

(2007) Tricia A. Thornton-Wells et al.   GENETIC EPIDEMIOLOGY

Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid

(2007) James Scott Miners et al.   JOURNAL OF NEUROSCIENCE METHODS

Immunocapture-based fluorometric assay for the measurement of insulin-degrading enzyme activity in brain tissue homogenates

(2007) James Scott Miners et al.   JOURNAL OF NEUROSCIENCE METHODS

Hypoxia increases Aβ generation by altering β- and γ-cleavage of APP

(2007) Liang Li et al.   NEUROBIOLOGY OF AGING

MMP-2, -3 and -9 levels and activity are not related to Aβ load in the frontal cortex in Alzheimer's disease

(2007) S. Baig et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy

(2007) J. S. Miners et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: Inverse correlation with Aβ levels

(2006) E. Hellström-Lindahl et al.   NEUROBIOLOGY OF AGING