Loss of angiotensin-converting enzyme 2 enhances TGF-β/Smad-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of obstructive nephropathy

Intratubular Renin-Angiotensin System in Hypertension

(2011) L. Gabriel Navar et al.   HYPERTENSION

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

New insights and perspectives on intrarenal renin-angiotensin system: Focus on intracrine/intracellular angiotensin II

(2011) Jia L. Zhuo et al.   PEPTIDES

Angiotensin-converting enzyme 2 is a key modulator of the renin–angiotensin system in cardiovascular and renal disease

(2010) Chris Tikellis et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

ACE2: more of Ang-(1–7) or less Ang II?

(2010) Carlos M Ferrario   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

The Protective Role of Smad7 in Diabetic Kidney Disease: Mechanism and Therapeutic Potential

(2010) H. Y. Chen et al.   DIABETES

Prevention of Angiotensin II–Mediated Renal Oxidative Stress, Inflammation, and Fibrosis by Angiotensin-Converting Enzyme 2

(2010) JiuChang Zhong et al.   HYPERTENSION

Loss of ACE2 accelerates time-dependent glomerular and tubulointerstitial damage in streptozotocin-induced diabetic mice

(2010) Atsushi Shiota et al.   HYPERTENSION RESEARCH

Increased ACE and Decreased ACE2 Expression in Kidneys from Patients with IgA Nephropathy

(2010) Sonoo Mizuiri et al.   NEPHRON CLINICAL PRACTICE

Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy

(2009) G. Y. Oudit et al.   DIABETES

Angiotensin II Induces Connective Tissue Growth Factor and Collagen I Expression via Transforming Growth Factor–β–Dependent and –Independent Smad Pathways

(2009) Fuye Yang et al.   HYPERTENSION

Renal ACE2 expression and activity is unaltered during established hypertension in adult SHRSP and TGR(mREN2)27

(2009) Jelena Kamilic et al.   HYPERTENSION RESEARCH

Expression of ACE and ACE2 in Individuals With Diabetic Kidney Disease and Healthy Controls

(2008) Sonoo Mizuiri et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Angiotensin II Up-Regulates Angiotensin I-Converting Enzyme (ACE), but Down-Regulates ACE2 via the AT1-ERK/p38 MAP Kinase Pathway

(2008) Vijay Koka et al.   AMERICAN JOURNAL OF PATHOLOGY

Smad7 as a therapeutic agent for chronic kidney diseases

(2008) Hui Yao Lan   Frontiers in Bioscience-Landmark

Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease

(2008) Heather N. Reich et al.   KIDNEY INTERNATIONAL

Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice

(2008) A. C. K. Chung et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION