The critical roles of activated stellate cells-mediated paracrine signaling, metabolism and onco-immunology in pancreatic ductal adenocarcinoma

Pancreatic stellate cells increase pancreatic cancer cells invasion through the hepatocyte growth factor /c-Met/survivin regulated by P53/P21

(2017) Xiao-Peng Yang et al.   EXPERIMENTAL CELL RESEARCH

Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells Under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice

(2017) Shu-Heng Jiang et al.   GASTROENTEROLOGY

Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice

(2017) Sho Endo et al.   GASTROENTEROLOGY

Inhibition of group 1 p21-activated kinases suppresses pancreatic stellate cell activation and increases survival of mice with pancreatic cancer

(2017) Dannel Yeo et al.   INTERNATIONAL JOURNAL OF CANCER

BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells

(2017) Ming-Xin An et al.   JOURNAL OF CELL BIOLOGY

Glucose Limitation Alters Glutamine Metabolism in MUC1-Overexpressing Pancreatic Cancer Cells

(2017) Teklab Gebregiworgis et al.   JOURNAL OF PROTEOME RESEARCH

Regional immunotherapy for liver and peritoneal metastases

(2017) Jeffrey Reha et al.   JOURNAL OF SURGICAL ONCOLOGY

Cancer cell chemokines direct chemotaxis of activated stellate cells in pancreatic ductal adenocarcinoma

(2017) Ishan Roy et al.   LABORATORY INVESTIGATION

IL6 Receptor Blockade Enhances Chemotherapy Efficacy in Pancreatic Ductal Adenocarcinoma

(2017) Kristen B. Long et al.   MOLECULAR CANCER THERAPEUTICS

Improving Chimeric Antigen Receptor-Modified T Cell Function by Reversing the Immunosuppressive Tumor Microenvironment of Pancreatic Cancer

(2017) Somala Mohammed et al.   MOLECULAR THERAPY

Exosome-Mediated Intercellular Communication Between Stellate Cells and Cancer Cells in Pancreatic Ductal Adenocarcinoma

(2017) Aurelia Lugea et al.   PANCREAS

Exosomes Derived From Pancreatic Stellate Cells

(2017) Tetsuya Takikawa et al.   PANCREAS

Pancreatic stellate cells in pancreatic cancer: In focus

(2017) A. Allam et al.   PANCREATOLOGY

Microenvironment in determining chemo-resistance in pancreatic cancer: Neighborhood matters

(2017) Patricia Dauer et al.   PANCREATOLOGY

Emerging roles of the CXCL12/CXCR4 axis in pancreatic cancer progression and therapy

(2017) Richard L. Sleightholm et al.   PHARMACOLOGY & THERAPEUTICS

Stromal cues regulate the pancreatic cancer epigenome and metabolome

(2017) Mara H. Sherman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo

(2017) Hannah M. Komar et al.   Scientific Reports

MiR-142 modulates human pancreatic cancer proliferation and invasion by targeting hypoxia-inducible factor 1 (HIF-1α) in the tumor microenvironments

(2017) Yebin Lu et al.   Biology Open

T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma

(2017) Ingunn M. Stromnes et al.   Cancer Immunology Research

Dysregulation of miRNA Expression in Cancer Associated Fibroblasts (CAFs) and Its Consequences on the Tumor Microenvironment

(2017) Maren Schoepp et al.   Cancers

Gold Nanoparticle Reprograms Pancreatic Tumor Microenvironment and Inhibits Tumor Growth

(2016) Sounik Saha et al.   ACS Nano

Enhancement of the CXCL12/CXCR4 axis due to acquisition of gemcitabine resistance in pancreatic cancer: effect of CXCR4 antagonists

(2016) Mamoru Morimoto et al.   BMC CANCER

Hypoxic stellate cells of pancreatic cancer stroma regulate extracellular matrix fiber organization and cancer cell motility

(2016) Masafumi Sada et al.   CANCER LETTERS

Heterogeneous Stromal Signaling within the Tumor Microenvironment Controls the Metastasis of Pancreatic Cancer

(2016) Agnieszka A. Rucki et al.   CANCER RESEARCH

Changing the course of pancreatic cancer – Focus on recent translational advances

(2016) Milind Javle et al.   CANCER TREATMENT REVIEWS

TGF-β-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3

(2016) Rachel A. Hesler et al.   CARCINOGENESIS

Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation

(2016) Christopher J. Tape et al.   CELL

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Transforming Growth Factor-  Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors

(2016) Y. Kang et al.   CLINICAL CANCER RESEARCH

IL-6/STAT3 Plays a Regulatory Role in the Interaction Between Pancreatic Stellate Cells and Cancer Cells

(2016) Shin Hamada et al.   DIGESTIVE DISEASES AND SCIENCES

ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth

(2016) Nicola Rath et al.   EMBO Molecular Medicine

Loss of P53 Function Activates JAK2–STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival

(2016) Sonja M. Wörmann et al.   GASTROENTEROLOGY

IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer

(2016) Thomas A Mace et al.   GUT

Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis

(2016) Li Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma

(2016) Elisabete F Carapuça et al.   JOURNAL OF PATHOLOGY

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

(2016) Shawn M Davidson et al.   NATURE MEDICINE

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

(2016) Hanane Laklai et al.   NATURE MEDICINE

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

(2016) Hong Jiang et al.   NATURE MEDICINE

Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells

(2016) K E Richards et al.   ONCOGENE

Pancreatic stellate cells regulate blood vessel density in the stroma of pancreatic ductal adenocarcinoma

(2016) Francesco Di Maggio et al.   PANCREATOLOGY

Targeting tumor tolerance: A new hope for pancreatic cancer therapy?

(2016) Daniel Delitto et al.   PHARMACOLOGY & THERAPEUTICS

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

(2016) J. R. Mayers et al.   SCIENCE

Key players in pancreatic cancer-stroma interaction: Cancer-associated fibroblasts, endothelial and inflammatory cells

(2016) Michael Friberg Bruun Nielsen et al.   WORLD JOURNAL OF GASTROENTEROLOGY

ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

(2016) Antonios Chronopoulos et al.   Nature Communications

Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy

(2016) J. Incio et al.   Cancer Discovery

GM-CSF Mediates Mesenchymal-Epithelial Cross-talk in Pancreatic Cancer

(2016) M. Waghray et al.   Cancer Discovery

MicroRNA-199a and -214 as potential therapeutic targets in pancreatic stellate cells in pancreatic tumor

(2016) Praneeth R. Kuninty et al.   Oncotarget

Can Targeting Stroma Pave the Way to Enhanced Antitumor Immunity and Immunotherapy of Solid Tumors?

(2016) E. Pure et al.   Cancer Immunology Research

Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia

(2016) Jason R. Pitarresi et al.   NEOPLASIA

ATRA modulates mechanical activation of TGF-β by pancreatic stellate cells

(2016) Muge Sarper et al.   Scientific Reports

T Cells Engineered against a Native Antigen Can Surmount Immunologic and Physical Barriers to Treat Pancreatic Ductal Adenocarcinoma

(2015) Ingunn M. Stromnes et al.   CANCER CELL

Collagen type V promotes the malignant phenotype of pancreatic ductal adenocarcinoma

(2015) Sonja Berchtold et al.   CANCER LETTERS

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer

(2015) C. J. Whatcott et al.   CLINICAL CANCER RESEARCH

Tumor mechanics and metabolic dysfunction

(2015) Jason C. Tung et al.   FREE RADICAL BIOLOGY AND MEDICINE

Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

(2015) Nagaraj S. Nagathihalli et al.   GASTROENTEROLOGY

Stromal biology and therapy in pancreatic cancer: a changing paradigm

(2015) Albrecht Neesse et al.   GUT

Genetics and Biology of Pancreatic Ductal Adenocarcinoma

(2015) Richard F. Dunne et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Metabolic Reprogramming of Immune Cells in Cancer Progression

(2015) Subhra K. Biswas   IMMUNITY

Strategies to relieve immunosuppression in pancreatic cancer

(2015) Max Schnurr et al.   Immunotherapy

TLR9 ligation in pancreatic stellate cells promotes tumorigenesis

(2015) Constantinos P. Zambirinis et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Chemokine Receptors CXCR4/CXCR7 and Their Primary Heterodimeric Ligands CXCL12 and CXCL12/High Mobility Group Box 1 in Pancreatic Cancer Growth and Development

(2015) Murtaza Shakir et al.   PANCREAS

The prognostic value of stroma in pancreatic cancer in patients receiving adjuvant therapy

(2015) Katherine M. Bever et al.   HPB

Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up

(2015) R. M. Perera et al.   Cancer Discovery

Mechanistic Effects of Calcitriol in Cancer Biology

(2015) Lorenza Díaz et al.   Nutrients

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

α-Mangostin inhibits hypoxia-driven ROS-induced PSC activation and pancreatic cancer cell invasion

(2014) Jianjun Lei et al.   CANCER LETTERS

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

(2014) Mara H. Sherman et al.   CELL

Sonic Hedgehog Paracrine Signaling Activates Stromal Cells to Promote Perineural Invasion in Pancreatic Cancer

(2014) X. Li et al.   CLINICAL CANCER RESEARCH

Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion

(2014) S. J. Coleman et al.   EMBO Molecular Medicine

Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium

(2014) Ovijit Chaudhuri et al.   NATURE MATERIALS

Monocytes Infiltrate the Pancreas via the MCP-1/CCR2 Pathway and Differentiate into Stellate Cells

(2014) Kazuko Ino et al.   PLoS One

MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies

(2014) GuemHee Baek et al.   Cell Reports

Dosage-Dependent Regulation of Pancreatic Cancer Growth and Angiogenesis by Hedgehog Signaling

(2014) Esha Mathew et al.   Cell Reports

The Carcinoma-Associated Fibroblast Expressing Fibroblast Activation Protein and Escape from Immune Surveillance

(2014) D. T. Fearon   Cancer Immunology Research

Connective tissue growth factor (CCN2) and microRNA-21 are components of a positive feedback loop in pancreatic stellate cells (PSC) during chronic pancreatitis and are exported in PSC-derived exosomes

(2014) Alyssa Charrier et al.   Journal of Cell Communication and Signaling

miR-210 regulates the interaction between pancreatic cancer cells and stellate cells

(2013) Tetsuya Takikawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner

(2013) T. A. Mace et al.   CANCER RESEARCH

Tumour–stroma interactions in pancreatic ductal adenocarcinoma: Rationale and current evidence for new therapeutic strategies

(2013) V. Heinemann et al.   CANCER TREATMENT REVIEWS

Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma

(2013) Abasi Ene–Obong et al.   GASTROENTEROLOGY

Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes

(2013) Raghu Kadaba et al.   JOURNAL OF PATHOLOGY

A bioengineered heterotypic stroma–cancer microenvironment model to study pancreatic ductal adenocarcinoma

(2013) Cole R. Drifka et al.   LAB ON A CHIP

Assessment of the stromal contribution to Sonic Hedgehog-dependent pancreatic adenocarcinoma

(2013) Helene Damhofer et al.   Molecular Oncology

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tolerance and exhaustion: defining mechanisms of T cell dysfunction

(2013) Andrea Schietinger et al.   TRENDS IN IMMUNOLOGY

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

(2013) Vikash P. Chauhan et al.   Nature Communications

Myeloid-Derived Suppressor Cells Attenuate TH1 Development through IL-6 Production to Promote Tumor Progression

(2013) H. Tsukamoto et al.   Cancer Immunology Research

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Plasma 25-Hydroxyvitamin D and Risk of Pancreatic Cancer

(2012) B. M. Wolpin et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial–mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway

(2012) Xuqi Li et al.   CANCER LETTERS

Regulation of pancreatic function by connective tissue growth factor (CTGF, CCN2)

(2012) Alyssa Charrier et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

(2012) Michael A Jacobetz et al.   GUT

Hypoxia enhances the interaction between pancreatic stellate cells and cancer cells via increased secretion of connective tissue growth factor

(2012) Daiki Eguchi et al.   JOURNAL OF SURGICAL RESEARCH

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

(2012) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

(2011) Marina Lesina et al.   CANCER CELL

STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis

(2011) R. B. Corcoran et al.   CANCER RESEARCH

Retinoic Acid–Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt–β-Catenin Signaling to Slow Tumor Progression

(2011) Fieke E.M. Froeling et al.   GASTROENTEROLOGY

High expression of Galectin-1 in pancreatic stellate cells plays a role in the development and maintenance of an immunosuppressive microenvironment in pancreatic cancer

(2011) Dong Tang et al.   INTERNATIONAL JOURNAL OF CANCER

Mechanical compression drives cancer cells toward invasive phenotype

(2011) J. M. Tse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells

(2010) Mert Erkan et al.   Molecular Cancer

Albumin mediates PPAR-γ or C/EBP-α-induced phenotypic changes in pancreatic stellate cells

(2009) Nayoung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Signal transduction in pancreatic stellate cells

(2009) Atsushi Masamune et al.   JOURNAL OF GASTROENTEROLOGY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

The Hedgehog Pathway and Pancreatic Cancer

(2009) Manuel Hidalgo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells

(2008) A. Vonlaufen et al.   CANCER RESEARCH

Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells

(2008) Atsushi Kanno et al.   INTERNATIONAL JOURNAL OF CANCER