Mechanistic Effects of Calcitriol in Cancer Biology

NF-κB in cancer therapy

(2015) Feng Li et al.   ARCHIVES OF TOXICOLOGY

A cis-acting element in the promoter of human ether à go-go 1 potassium channel gene mediates repression by calcitriol in human cervical cancer cells

(2015) V. Cázares-Ordoñez et al.   Biochemistry and Cell Biology

HDAC1 overexpression independently predicts biochemical recurrence and is associated with rapid tumor cell proliferation and genomic instability in prostate cancer

(2015) Christoph Burdelski et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

IL-10 inhibits while calcitriol reestablishes placental antimicrobial peptides gene expression

(2015) Andrea Olmos-Ortiz et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Calcitriol and its analogues enhance the antiproliferative activity of gefitinib in breast cancer cells

(2015) Mariana Segovia-Mendoza et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Introduction to the molecular basis of cancer metabolism and the Warburg effect

(2015) Darleen C. Ngo et al.   MOLECULAR BIOLOGY REPORTS

Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity

(2015) K Cao et al.   ONCOGENE

Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells

(2015) Sapna Singh et al.   TUMOR BIOLOGY

Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma

(2015) Chong Hao et al.   BMC CANCER

Severe 25-hydroxyvitamin D deficiency identifies a poor prognosis in patients with hepatocellular carcinoma - a prospective cohort study

(2014) F. Finkelmeier et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Hepatocellular carcinoma epidemiology

(2014) Cristina Bosetti et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Calcitriol restores antiestrogen responsiveness in estrogen receptor negative breast cancer cells: A potential new therapeutic approach

(2014) Nancy Santos-Martínez et al.   BMC CANCER

In vivo dual targeting of the oncogenic Ether-à-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors

(2014) Janice García-Quiroz et al.   BMC CANCER

Prediagnostic circulating vitamin D levels and risk of hepatocellular carcinoma in European populations: A nested case-control study

(2014) Veronika Fedirko et al.   HEPATOLOGY

Expression of Histone Deacetylases HDAC1, HDAC2, HDAC3, and HDAC6 in Invasive Ductal Carcinomas of the Breast

(2014) Jinwon Seo et al.   Journal of Breast Cancer

Actions of 1,25(OH)2-vitamin D3 on the cellular cycle depend on VDR and p38 MAPK in skeletal muscle cells

(2014) Ana P Irazoqui et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Activation of the intrinsic apoptosis pathway contributes to the induction of apoptosis in hepatocellular carcinoma cells by valproic acid

(2014) WEIHUA YANG et al.   Oncology Letters

The Role of Dietary Histone Deacetylases (HDACs) Inhibitors in Health and Disease

(2014) Shalome Bassett et al.   Nutrients

Associations of serum 25-hydroxyvitamin D with overall and breast cancer–specific mortality in a multiethnic cohort of breast cancer survivors

(2013) Adriana Villaseñor et al.   CANCER CAUSES & CONTROL

Progesterone Enhances Calcitriol Antitumor Activity by Upregulating Vitamin D Receptor Expression and Promoting Apoptosis in Endometrial Cancer Cells

(2013) L. R. Lee et al.   Cancer Prevention Research

A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response

(2013) Ning Ding et al.   CELL

HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates

(2013) Praveen Rajendran et al.   Epigenetics

Vitamin D Receptor Inhibits Nuclear Factor κB Activation by Interacting with IκB Kinase β Protein

(2013) Yunzi Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of VDR in 1α,25-dihydroxyvitamin D3-dependent non-genomic activation of MAPKs, Src and Akt in skeletal muscle cells

(2013) Claudia Buitrago et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Calcitriol reduces thrombospondin-1 and increases vascular endothelial growth factor in breast cancer cells: Implications for tumor angiogenesis

(2013) Janice García-Quiroz et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

ERK 5/MAPK pathway has a major role in 1α,25-(OH)2 vitamin D3-induced terminal differentiation of myeloid leukemia cells

(2013) Xuening Wang et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Targeting CD44-STAT3 Signaling by Gemini Vitamin D Analog Leads to Inhibition of Invasion in Basal-Like Breast Cancer

(2013) Jae Young So et al.   PLoS One

Genetic Analyses Reveal a Role for Vitamin D Insufficiency in HCV-Associated Hepatocellular Carcinoma Development

(2013) Christian M. Lange et al.   PLoS One

The HDAC Inhibitor LBH589 Induces ERK-Dependent Prometaphase Arrest in Prostate Cancer via HDAC6 Inactivation and Down-Regulation

(2013) Mei-Jen Chuang et al.   PLoS One

Vitamin D and chronic obstructive pulmonary disease: hype or reality?

(2013) Wim Janssens et al.   Lancet Respiratory Medicine

Vitamin D improves the angiogenic properties of endothelial progenitor cells

(2012) M. Grundmann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

1α,25-dihydroxyvitamin D3 modulates the interaction between immune and colon cancer cells

(2012) Hanna Bessler et al.   BIOMEDICINE & PHARMACOTHERAPY

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Multiple Biological Activities of Lactic Acid in Cancer: Influences on Tumor Growth,Angiogenesis and Metastasis

(2012) Suveera Dhup et al.   CURRENT PHARMACEUTICAL DESIGN

Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects

(2012) Julia Beilfuss et al.   CYTOKINE

Calcitriol downregulates TNF-α and IL-6 expression in cultured placental cells from preeclamptic women

(2012) Nancy Noyola-Martínez et al.   CYTOKINE

Vitamin D and colon cancer

(2012) Fábio Pereira et al.   ENDOCRINE-RELATED CANCER

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

1,25-Dihydroxyvitamin D3 Suppresses Telomerase Expression and Human Cancer Growth through MicroRNA-498

(2012) Ravi Kasiappan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vitamin D Inhibits Monocyte/Macrophage Proinflammatory Cytokine Production by Targeting MAPK Phosphatase-1

(2012) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Suppressive Effect of 19-nor-1α-25-Dihydroxyvitamin D2 on Gastric Cancer Cells and Peritoneal Metastasis Model

(2012) Mi Ra Park et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Epigenetic regulation of the 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1) in colon cancer cells

(2012) Julia Höbaus et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Hepatocellular carcinoma

(2012) Alejandro Forner et al.   LANCET

Health risks and benefits from calcium and vitamin D supplementation: Women's Health Initiative clinical trial and cohort study

(2012) R. L. Prentice et al.   OSTEOPOROSIS INTERNATIONAL

Epigenetic regulation of caloric restriction in aging

(2011) Yuanyuan Li et al.   BMC Medicine

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Circulating Levels of Vitamin D and Colon and Rectal Cancer: The Physicians' Health Study and a Meta-analysis of Prospective Studies

(2011) J. E. Lee et al.   Cancer Prevention Research

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Intestinal Inflammation and Cancer

(2011) Thomas A. Ullman et al.   GASTROENTEROLOGY

VDR/RXR and TCF4/β-Catenin Cistromes in Colonic Cells of Colorectal Tumor Origin: Impact onc-FOSandc-MYCGene Expression

(2011) Mark B. Meyer et al.   MOLECULAR ENDOCRINOLOGY

Vitamin D - roles in women's reproductive health?

(2011) Magdalena Grundmann et al.   Reproductive Biology and Endocrinology

Cancer-related inflammation: Common themes and therapeutic opportunities

(2011) Frances R. Balkwill et al.   SEMINARS IN CANCER BIOLOGY

Management of osteoporosis in liver disease

(2011) Núria Guañabens et al.   Clinics and Research in Hepatology and Gastroenterology

Impact of vitamin D metabolism on clinical epigenetics

(2011) Heidrun Karlic et al.   Clinical Epigenetics

Epigenetic Regulation of Vitamin D 24-Hydroxylase/CYP24A1 in Human Prostate Cancer

(2010) W. Luo et al.   CANCER RESEARCH

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Calcitriol enhances gemcitabine antitumor activity in vitro and in vivo by promoting apoptosis in a human pancreatic carcinoma model system

(2010) Wei-Dong Yu et al.   CELL CYCLE

Vitamin D: Evolutionary, Physiological and Health Perspectives

(2010) Michael F. Holick   CURRENT DRUG TARGETS

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

Vitamin D and prostate cancer: The role of membrane initiated signaling pathways in prostate cancer progression

(2010) Sandra Karlsson et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

1,25(OH)2vitamin D3 inhibits cell proliferation by promoting cell cycle arrest without inducing apoptosis and modifies cell morphology of mesenchymal multipotent cells

(2010) Jorge N. Artaza et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The Vitamin D and Cancer Conundrum: Aiming at a Moving Target

(2010) Cheryl D. Toner et al.   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

Stimulation of Sirt1-Regulated FoxO Protein Function by the Ligand-Bound Vitamin D Receptor

(2010) B.-S. An et al.   MOLECULAR AND CELLULAR BIOLOGY

Epigenetic control of a VDR-governed feed-forward loop that regulates p21 ( waf1/cip1 ) expression and function in non-malignant prostate cells

(2010) James L. Thorne et al.   NUCLEIC ACIDS RESEARCH

Vitamin D for Cancer Prevention: Global Perspective

(2009) Cedric F. Garland et al.   ANNALS OF EPIDEMIOLOGY

Treatment of K562 cells with 1,25-dihydroxyvitamin D3 induces distinct alterations in the expression of apoptosis-related genes BCL2, BAX, BCLXL, and p21

(2009) Sefa Kizildag et al.   ANNALS OF HEMATOLOGY

Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion

(2009) Yadi Wu et al.   CANCER CELL

Role of Vitamin D Receptor in the Antiproliferative Effects of Calcitriol in Tumor-Derived Endothelial Cells and Tumor Angiogenesis In vivo

(2009) I. Chung et al.   CANCER RESEARCH

Molecular pathways mediating the anti-inflammatory effects of calcitriol: implications for prostate cancer chemoprevention and treatment

(2009) Aruna V Krishnan et al.   ENDOCRINE-RELATED CANCER

1α,25-Dihydroxyvitamin D3Reduces c-Myc Expression, Inhibiting Proliferation and Causing G1Accumulation in C4-2 Prostate Cancer Cells

(2009) JoyAnn N. Phillips Rohan et al.   ENDOCRINOLOGY

Calcitriol inhibits Ether-à go-go potassium channel expression and cell proliferation in human breast cancer cells

(2009) Rocío García-Becerra et al.   EXPERIMENTAL CELL RESEARCH

Cyclical Chromatin Looping and Transcription Factor Association on the Regulatory Regions of the p21 (CDKN1A) Gene in Response to 1α,25-Dihydroxyvitamin D3

(2009) Anna Saramäki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcitriol inhibits TNF-α-induced inflammatory cytokines in human trophoblasts

(2009) Lorenza Díaz et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Multifunctional Enhancers Regulate Mouse and Human Vitamin D Receptor Gene Transcription

(2009) Lee A. Zella et al.   MOLECULAR ENDOCRINOLOGY

Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells

(2009) N J Sullivan et al.   ONCOGENE

1,25-Dihydroxyvitamin D3 regulates VEGF production through a vitamin D response element in the VEGF promoter

(2008) Anna Cardus et al.   ATHEROSCLEROSIS

TNF: A master switch for inflammation to cancer

(2008) Gautam Sethi   Frontiers in Bioscience-Landmark

Multistep regulation of telomerase during differentiation of HL60 cells

(2008) Osamu Yamada et al.   JOURNAL OF LEUKOCYTE BIOLOGY

1 ,25-Dihydroxyvitamin D3 potentiates cisplatin antitumor activity by p73 induction in a squamous cell carcinoma model

(2008) Y. Ma et al.   MOLECULAR CANCER THERAPEUTICS

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Calcitriol affects hCG gene transcription in cultured human syncytiotrophoblasts

(2008) David Barrera et al.   Reproductive Biology and Endocrinology