Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis

Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors

(2015) Xiaofei Chen et al.   Epigenetics

Suppressor of Cytokine Signaling (SOCS) Genes Are Silenced by DNA Hypermethylation and Histone Deacetylation and Regulate Response to Radiotherapy in Cervical Cancer Cells

(2015) Moon-Hong Kim et al.   PLoS One

Luteolin decreases invasiveness, deactivates STAT3 signaling, and reverses interleukin-6 induced epithelial–mesenchymal transition and matrix metalloproteinase secretion of pancreatic cancer cells

(2015) Xince Huang et al.   OncoTargets and Therapy

Pro-malignant properties of STAT3 during chronic inflammation

(2015) Marco Demaria et al.   Oncotarget

Smarter drugs emerging in pancreatic cancer therapy

(2014) A. Kleger et al.   ANNALS OF ONCOLOGY

The role of CXC-chemokine receptor CXCR2 and suppressor of cytokine signaling-3 (SOCS-3) in renal cell carcinoma

(2014) Anastasios Stofas et al.   BMC CANCER

IL-23 selectively promotes the metastasis of colorectal carcinoma cells with impaired Socs3 expression via the STAT5 pathway

(2014) Le Zhang et al.   CARCINOGENESIS

Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells

(2014) Shanshan Wan et al.   GASTROENTEROLOGY

Interleukin-6: a villain in the drama of pancreatic cancer development and progression

(2014) Reinhild Holmer et al.   Hepatobiliary & Pancreatic Diseases International

Promoter methylation of tumor suppressor genes in pre-neoplastic lesions; potential marker of disease recurrence

(2014) Claudia Rengucci et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Loss of Suppressors of Cytokine Signaling 3 Promotes Aggressiveness in Hepatocellular Carcinoma

(2014) Wen-Yong Wu et al.   JOURNAL OF INVESTIGATIVE SURGERY

SOCS3 methylation in synergy with Reg3A overexpression promotes cell growth in pancreatic cancer

(2014) Jun Wang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

(2014) Jan Mauer et al.   NATURE IMMUNOLOGY

Kaposi's Sarcoma-Associated Herpesvirus (KSHV) vIL-6 Promotes Cell Proliferation and Migration by Upregulating DNMT1 via STAT3 Activation

(2014) Jing Wu et al.   PLoS One

SOCS3 promotor hypermethylation and STAT3-NF-κB interaction downregulate SOCS3 expression in human coronary artery smooth muscle cells

(2013) Kajari Dhar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Gene methylation and silencing ofSOCS3in mantle cell lymphoma

(2013) Ommoleila Molavi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Inflammatory networks and immune surveillance of pancreatic carcinoma

(2013) Robert H Vonderheide et al.   CURRENT OPINION IN IMMUNOLOGY

Pancreatic cancer: A comprehensive review and update

(2013) Thiruvengadam Muniraj et al.   DM DISEASE-A-MONTH

Aberrant DNA methyltransferase expression in pancreatic ductal adenocarcinoma development and progression

(2013) Jun Gao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

High expression of IL-17 and IL-17RE associate with poor prognosis of hepatocellular carcinoma

(2013) Rui Liao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer

(2012) Yi Li et al.   CARCINOGENESIS

Chronic inflammation, immune escape, and oncogenesis in the liver: A unique neighborhood for novel intersections

(2012) Jimmy K. Stauffer et al.   HEPATOLOGY

Suppressor of Cytokine Signaling 3 Inhibits Breast Tumor Kinase Activation of STAT3

(2012) Yiwei Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression

(2011) Akihisa Fukuda et al.   CANCER CELL

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

(2011) Marina Lesina et al.   CANCER CELL

Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells

(2010) Jacqueline A. Gasche et al.   INTERNATIONAL JOURNAL OF CANCER

Pancreatic Cancer

(2010) Manuel Hidalgo   NEW ENGLAND JOURNAL OF MEDICINE

Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior

(2010) Francesco Pierconti et al.   PROSTATE

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

(2009) Julia Bollrath et al.   CANCER CELL

 1 Integrin Adhesion Enhances IL-6-Mediated STAT3 Signaling in Myeloma Cells: Implications for Microenvironment Influence on Tumor Survival and Proliferation

(2009) K. H. Shain et al.   CANCER RESEARCH

Activation of DNA Methyltransferase 1 by EBV Latent Membrane Protein 2A Leads to Promoter Hypermethylation of PTEN Gene in Gastric Carcinoma

(2009) R. Hino et al.   CANCER RESEARCH

STAT3 as a target for inducing apoptosis in solid and hematological tumors

(2008) Khandaker Al Zaid Siddiquee et al.   CELL RESEARCH