TLR9 ligation in pancreatic stellate cells promotes tumorigenesis

Pancreatic Cancer, Inflammation, and Microbiome

(2014) Constantinos P. Zambirinis et al.   CANCER JOURNAL

TLR7 Promotes Tumor Progression, Chemotherapy Resistance, and Poor Clinical Outcomes in Non-Small Cell Lung Cancer

(2014) S. Chatterjee et al.   CANCER RESEARCH

Disruption of CCR5-Dependent Homing of Regulatory T Cells Inhibits Tumor Growth in a Murine Model of Pancreatic Cancer

(2014) M. C. B. Tan et al.   JOURNAL OF IMMUNOLOGY

Tumor Cell–Derived MMP3 Orchestrates Rac1b and Tissue Alterations That Promote Pancreatic Adenocarcinoma

(2014) Christine Mehner et al.   MOLECULAR CANCER RESEARCH

Eotaxin-1 promotes prostate cancer cell invasion via activation of the CCR3-ERK pathway and upregulation of MMP-3 expression

(2014) FENG ZHU et al.   ONCOLOGY REPORTS

HMGB1 plays a critical role in vascular inflammation and lesion formation via toll-like receptor 9

(2013) Yoichiro Hirata et al.   ATHEROSCLEROSIS

DNA from dead cancer cells induces TLR9-mediated invasion and inflammation in living cancer cells

(2013) Johanna Tuomela et al.   BREAST CANCER RESEARCH AND TREATMENT

Role of Immune Cells and Immune-Based Therapies in Pancreatitis and Pancreatic Ductal Adenocarcinoma

(2013) Lei Zheng et al.   GASTROENTEROLOGY

Inflammation, Autophagy, and Obesity: Common Features in the Pathogenesis of Pancreatitis and Pancreatic Cancer

(2013) Ilya Gukovsky et al.   GASTROENTEROLOGY

The Epidemiology of Pancreatitis and Pancreatic Cancer

(2013) Dhiraj Yadav et al.   GASTROENTEROLOGY

Oncogenic K-Ras requires activation for enhanced activity

(2013) H Huang et al.   ONCOGENE

Oncogenic K-Ras and Loss of Smad4 Mediate Invasion by Activating an EGFR/NF-κB Axis That Induces Expression of MMP9 and uPA in Human Pancreas Progenitor Cells

(2013) Alakesh Bera et al.   PLoS One

Immunosuppressive MDSCs induced by TLR signaling during infection and role in resolution of inflammation

(2013) Anuradha Ray et al.   Frontiers in Cellular and Infection Microbiology

Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia

(2012) Yuliya Pylayeva-Gupta et al.   CANCER CELL

Depressed Levels of Prostaglandin F2  in Mice Lacking Akr1b7 Increase Basal Adiposity and Predispose to Diet-Induced Obesity

(2012) F. E. Volat et al.   DIABETES

Dendritic Cell Populations With Different Concentrations of Lipid Regulate Tolerance and Immunity in Mouse and Human Liver

(2012) Junaid Ibrahim et al.   GASTROENTEROLOGY

Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans

(2012) Atsuo Ochi et al.   JOURNAL OF CLINICAL INVESTIGATION

MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells

(2012) Atsuo Ochi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor-Infiltrating Monocytic Myeloid-Derived Suppressor Cells Mediate CCR5-Dependent Recruitment of Regulatory T Cells Favoring Tumor Growth

(2012) E. Schlecker et al.   JOURNAL OF IMMUNOLOGY

Familial pancreatic cancer—current knowledge

(2012) Detlef K. Bartsch et al.   Nature Reviews Gastroenterology & Hepatology

CCL11 (eotaxin-1): A new diagnostic serum marker for prostate cancer

(2012) Manisha Agarwal et al.   PROSTATE

High-mobility group box family of proteins: ligand and sensor for innate immunity

(2012) Hideyuki Yanai et al.   TRENDS IN IMMUNOLOGY

Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression

(2011) Akihisa Fukuda et al.   CANCER CELL

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

(2011) Marina Lesina et al.   CANCER CELL

Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13

(2011) Rachel F. Gabitass et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer

(2011) M E Caldwell et al.   ONCOGENE

Early Growth Response Gene-2 (Egr-2) Regulates the Development of B and T Cells

(2011) Suling Li et al.   PLoS One

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Breaking the NF- B and STAT3 Alliance Inhibits Inflammation and Pancreatic Tumorigenesis

(2010) Y.-J. Surh et al.   Cancer Prevention Research

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis

(2010) Mary Mohrin et al.   Cell Stem Cell

Phenotype and Genotype of Pancreatic Cancer Cell Lines

(2010) Emily L. Deer et al.   PANCREAS

Isolation of Quiescent Human Pancreatic Stellate Cells: A Promising in vitro Tool for Studies of Human Pancreatic Stellate Cell Biology

(2010) Alain Vonlaufena et al.   PANCREATOLOGY

Reverse transcription-quantitative polymerase chain reaction: description of a RIN-based algorithm for accurate data normalization

(2009) Alexandre Ho-Pun-Cheung et al.   BMC MOLECULAR BIOLOGY

Role of Eotaxin-1 Signaling in Ovarian Cancer

(2009) V. Levina et al.   CLINICAL CANCER RESEARCH

Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor

(2009) Michael K. Connolly et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells

(2008) A. Vonlaufen et al.   CANCER RESEARCH

Pancreatic stellate cells express Toll-like receptors

(2008) Atsushi Masamune et al.   JOURNAL OF GASTROENTEROLOGY

Role of Toll-like receptors in gastrointestinal malignancies

(2008) M Fukata et al.   ONCOGENE