TGF-β-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3
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Title
TGF-β-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3
Authors
Keywords
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Journal
CARCINOGENESIS
Volume 37, Issue 11, Pages 1041-1051
Publisher
Oxford University Press (OUP)
Online
2016-09-08
DOI
10.1093/carcin/bgw093
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- (2015) Xin Long et al. BRITISH JOURNAL OF HAEMATOLOGY
- Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
- (2015) Xiaofeng Zheng et al. NATURE
- Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma
- (2015) Richard A Moffitt et al. NATURE GENETICS
- Pancreatic cancer: from state-of-the-art treatments to promising novel therapies
- (2015) Ignacio Garrido-Laguna et al. Nature Reviews Clinical Oncology
- The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2
- (2015) Nicolas Skrypek et al. Oncotarget
- Gene Expression Levels as Predictive Markers of Outcome in Pancreatic Cancer after Gemcitabine-Based Adjuvant Chemotherapy
- (2015) Hayato Fujita et al. NEOPLASIA
- Cancer statistics, 2014
- (2014) Rebecca Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
- (2014) Berna C. Özdemir et al. CANCER CELL
- Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
- (2014) Andrew D. Rhim et al. CANCER CELL
- Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States
- (2014) L. Rahib et al. CANCER RESEARCH
- Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy
- (2014) Mara H. Sherman et al. CELL
- Gemcitabine: Metabolism and molecular mechanisms of action, sensitivity and chemoresistance in pancreatic cancer
- (2014) Lucas de Sousa Cavalcante et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Improved vectors and genome-wide libraries for CRISPR screening
- (2014) Neville E Sanjana et al. NATURE METHODS
- Molecular mechanisms of epithelial–mesenchymal transition
- (2014) Samy Lamouille et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Biomarkers of TGF-β Signaling Pathway and Prognosis of Pancreatic Cancer
- (2014) Milind Javle et al. PLoS One
- Prognostic Value of Human Equilibrative NucleosideTransporter1 in Pancreatic Cancer Receiving Gemcitabin-Based Chemotherapy: A Meta-Analysis
- (2014) Zhu-Qing Liu et al. PLoS One
- Interaction of CCN1 with αvβ3 integrin induces P-glycoprotein and confers vinblastine resistance in renal cell carcinoma cells
- (2013) Qing-Zhi Long et al. ANTI-CANCER DRUGS
- Pancreatic Stellate Cell Models for Transcriptional Studies of Desmoplasia-Associated Genes
- (2013) Angela Mathison et al. PANCREATOLOGY
- Human Concentrative Nucleoside Transporter 3 Transfection with Ultrasound and Microbubbles in Nucleoside Transport Deficient HEK293 Cells Greatly Increases Gemcitabine Uptake
- (2013) Robert J. Paproski et al. PLoS One
- Molecular Analysis of Precursor Lesions in Familial Pancreatic Cancer
- (2013) Tatjana Crnogorac-Jurcevic et al. PLoS One
- CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer
- (2013) A. Neesse et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
- (2013) Ophir Shalem et al. SCIENCE
- MUC1 induces drug resistance in pancreatic cancer cells via upregulation of multidrug resistance genes
- (2013) S Nath et al. Oncogenesis
- Predictive and prognostic roles of ribonucleotide reductase M1 in resectable pancreatic adenocarcinoma
- (2012) Hao Xie et al. CANCER
- Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
- (2012) Paolo P. Provenzano et al. CANCER CELL
- The Impact of the Activated Stroma on Pancreatic Ductal Adenocarcinoma Biology and Therapy Resistance
- (2012) Mert Erkan et al. CURRENT MOLECULAR MEDICINE
- Molecular Targets of Gemcitabine Action: Rationale for Development of Novel Drugs and Drug Combinations
- (2012) Maha Elnaggar et al. CURRENT PHARMACEUTICAL DESIGN
- Levels of Gemcitabine Transport and Metabolism Proteins Predict Survival Times of Patients Treated With Gemcitabine for Pancreatic Adenocarcinoma
- (2012) Raphaël Maréchal et al. GASTROENTEROLOGY
- CYR61 controls p53 and NF-κB expression through PI3K/Akt/mTOR pathways in carboplatin-induced ovarian cancer cells
- (2011) Kwang-Beom Lee et al. CANCER LETTERS
- The Matricellular Protein Cysteine-rich Protein 61 (CCN1/Cyr61) Enhances Physiological Adaptation of Retinal Vessels and Reduces Pathological Neovascularization Associated with Ischemic Retinopathy
- (2011) Adeel Hasan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cyr61/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis
- (2011) Inamul Haque et al. Molecular Cancer
- Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets
- (2011) Joon-Il Jun et al. NATURE REVIEWS DRUG DISCOVERY
- Precursor lesions in pancreatic cancer: morphological and molecular pathology
- (2011) Christopher J. Scarlett et al. PATHOLOGY
- Human Equilibrative Nucleoside Transporter 1 and Human Concentrative Nucleoside Transporter 3 Predict Survival after Adjuvant Gemcitabine Therapy in Resected Pancreatic Adenocarcinoma
- (2009) R. Marechal et al. CLINICAL CANCER RESEARCH
- Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression
- (2008) R. F. Hwang et al. CANCER RESEARCH
- Cysteine-Rich Protein 61 and Connective Tissue Growth Factor Induce Deadhesion and Anoikis of Retinal Pericytes
- (2008) Haibo Liu et al. ENDOCRINOLOGY
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